Validation of an LC–MS Method for the Detection and Quantification of BZP and TFMPP and their Hydroxylated Metabolites in Human Plasma and its Application to the Pharmacokinetic Study of TFMPP in Humans*

Abstract: An LC–MS method was developed for benzylpiperazine (BZP) and trifluoromethylphenylpiperazine (TFMPP), constituents of “party pills” or “legal herbal highs,” and their metabolites in human blood plasma. Compounds were resolved using a mixture of ammonium formate (pH 4.5, 0.01 M) and acetonitrile (flow rate of 1.0 mL/min) with a C18 column. Calibration curves were linear from 1 to 50 ng/mL (R² > 0.99); the lower limit of quantification (LLOQ) was 5 ng/mL; the accuracy was >90%; the intra‐ and interday relative standard deviations (R.S.D) were <5% and <10%, respectively. Human plasma concentrations of TFMPP were measured in blood samples taken from healthy adults (n = 6) over 24 h following a 60‐mg oral dose of TFMPP: these peaked at 24.10 ng/mL (±1.8 ng/mL) (C_max) after 90 min (T_max). Plasma concentrations of 1‐(3‐trifluoromethyl‐4‐hydroxyphenyl) piperazine peaked at 20.2 ng/mL (±4.6 ng/mL) after 90 min. TFMPP had two disposition phases (t_½ = 2.04 h (±0.19 h) and 5.95 h (±1.63 h). Apparent clearance (Cl/F) was 384 L/h (±45 L/h).     

Criminal career progression among serious youthful offenders in Australia

An important question from research on criminal careers is whether the processes that generate participation in criminal activity are similar to those that drive offending frequency among those who have initiated. This article considers basic demographic correlates asking whether those factors are associated with both initial and sustained early adulthood criminality in Australia. Three findings emerged from the study: (1) the offenders exhibited high levels of criminal activity during early adulthood; (2) males were more likely than females to offend and offend at higher rates as adults; and (3) Indigenous youth were more likely than non-Indigenous youth to offend and offend at higher rates as adults. Overall, the study results showed that basic correlates of crime were linked to both participation and frequency of offending in early adulthood—even within a sample of serious offenders. The article addresses the theoretical implications of the findings and directions for future research.     

Informal Controls and the Explanation of Propensity to Offend: A Test in Two Urban Samples

Propensity to offend is an important and stable predictor of offending. A person’s propensity is often thought of as a multidimensional trait consisting of morality and low self-control. The aim of this paper is to explain individual differences in propensity to offend as one single construct and two of its dimensions, namely morality and low self-control. It is well established that low levels of morality and low self-control increase the risk of offending. However, there is less empirical research that focuses on the main predictors of morality and self-control. Therefore the main research question for this study is to explain to what extent parental attachment, parental control and the school social bond have a direct effect on one’s propensity to offend (low morality or delinquency tolerance and low self-control). The data are drawn from two different samples of young adolescents in Antwerp, Belgium (N = 2,486), and Halmstad, Sweden (N = 1,003). The results show that parental control, parental attachment and the school social bond have direct effects on individual differences in propensity to offend, regardless of individual background variables. The results are highly equivalent in both samples. The similarity of the results across two independent samples suggests that the findings are stable. Implications for further studies are discussed.     

Exploring gender differences in dating violence/harassment prevention programming in middle schools: results from a randomized experiment

In this study, we randomly assigned 123 sixth and seventh grade classrooms from seven middle schools in the greater Cleveland area to one of two five-session curricula addressing gender violence/sexual harassment (GV/SH) or to a no-treatment control group. A baseline survey and two follow-up surveys were administered immediately after the treatment (Wave 2) and about six months post-treatment (Wave 3). In an earlier paper, we demonstrated the effectiveness of two approaches to youth GV/SH prevention programming (a fact-based, law and justice curriculum and an interaction-based curriculum). In this paper, we explored whether these largely positive findings remain for both girls and boys, including whether girls experience higher levels of GV/SH than boys. Most of our statistical models proved to be non-statistically significant. However, in 2 of our 48 victimization/perpetration (any violence, sexual violence and non-sexual violence) models (across two post-intervention follow-up points), we observed that the interventions reduced peer (male or female, non-dating partner) sexual violence victimization and reduced peer perpetration, but another outcome model indicated that the interventions increased dating perpetration. These mixed findings will need to be explored further in future research. Regarding our primary research question, we observed no statistically significant differences for the treatment multiplied by gender interaction terms for any of the perpetration or victimization outcome models, suggesting that the treatment had similar effects on girls and boys. However, we did observe that boys are more involved in violence than girls: both as victims and perpetrators. Boys experienced significantly more of three types of victimization from peers and dating partners compared to what girls experienced at the hands of their peers and dating partners. As perpetrators, boys committed more sexual victimization against peers (immediately post-intervention only) and more sexual victimization against dating partners than girls. The implications of these results are discussed.     

Toward a Typology of High-Risk Major Stressful Events and Situations in Posttraumatic Stress Disorder and Related Psychopathology

The diagnosis of posttraumatic stress disorder (PTSD) was introduced in 1980 with the publication of the Diagnostic and Statistical Manual of the American Psychiatric Association, Third Edition (DSM-III). DSM-III put forward a novel syndrome consisting of intrusive, avoidance/numbing, and arousal symptoms as distinctive psychopathology following exposure to traumatic events. The traumatic stressors, although expanded in later editions published in 1987 (DSM-III-R) and 1994 (DSM-IV), focus on life-threatening events and situations. However, at least 12 studies, most of them recent, have found associations between the PTSD symptoms and the PTSD symptom syndrome with stressors, such as unemployment and divorce that would not qualify, even in the broadened DSM-IV diagnosis, as traumatic stressors. These findings challenge the basic assumption on which the PTSD diagnosis is based, the assumption that exposure to life-threatening stressors is the primary cause of a unique set of stress response symptoms. The purpose of this paper is to show how to confront this challenge by developing a typology of stressful situations and events that can be tested systematically for their relation to the PTSD symptom syndrome and other relevant variables. The typology includes but is not limited to the types of situations and events defined as "traumatic" in the DSMs.     

Neuropsychological Tests are Poor at Assessing the Frontal Lobes, Executive Functions, and Neurobehavioral Symptoms of Traumatically Brain-Injured Patients

The frontal lobes play a major role in the regulation of our emotions and behavior, planning, decision making, social conduct, actions, and executive functions. They are quite vulnerable to damage when an individual sustains a moderate or severe traumatic brain injury. Patients who sustain damage to their frontal lobes may not complain of any cognitive or neurobehavioral symptoms. They often do not show any abnormalities on standardized neuropsychological tests, particularly when the anterior and ventral areas of their frontal lobes are damaged. When these patients are observed in unstructured, novel, or complex real-world settings, they frequently exhibit cognitive difficulties, neurobehavioral symptoms, and problems with their executive functions. Since standardized neuropsychological tests are generally poor at assessing these problems and symptoms, neuropsychologists may not be aware of these problems if they have never observed these patients function in real-world settings or have never interviewed the significant others of these patients. As a consequence, neuropsychologists should not rely solely on the quantitative test data of these patients since it may provide inaccurate and misleading information.     

A New U.S.-Colombian Relationship: Transnational Crime and U.S. National Security

To fight transnational crime, the United States needs to strengthen its cooperation with Colombia. This initiative, according to the authors, will not only be cost-effective for the United States, it will also signal U.S. willingness to work “by, with and through” other states, and may make possible an expanded regional framework to act against the criminal cartels.     

Differences in Neuropsychological Functioning Between Homicidal and Nonviolent Schizophrenia Samples

Few studies have compared performance on neurocognitive measures between violent and nonviolent schizophrenia samples. A better understanding of neurocognitive dysfunction in violent individuals with schizophrenia could increase the efficacy of violence reduction strategies and aid in risk assessment and adjudication processes. This study aimed to compare neuropsychological performance between 25 homicide offenders with schizophrenia and 25 nonviolent schizophrenia controls. The groups were matched for age, race, sex, and handedness. Independent t‐tests and Mann–Whitney U‐tests were used to compare the schizophrenia groups’ performance on measures of cognition, including composite scores assessing domain level functioning and individual neuropsychological tests. Results indicated the violent schizophrenia group performed worse on measures of memory and executive functioning, and the Intellectual Functioning composite score, when compared to the nonviolent schizophrenia sample. These findings replicate previous research documenting neuropsychological deficits specific to violent individuals with schizophrenia and support research implicating fronto‐limbic dysfunction among violent offenders with schizophrenia.