An analytical evaluation of eight on-site oral fluid drug screening devices using laboratory confirmation results from oral fluid

A decaying cadaver emits volatile organic compounds that are used by necrophilous and necrophagous insects in order to find their brood substrate. Although volatile organic compounds (VOCs) that are released by carcasses have been identified, little is known about the specific compounds that are used by these insects while searching for a brood substrate. Therefore, we have investigated the chemical ecology involved in the attraction of the necrophagous hide beetle Dermestes maculatus, which feeds as an adult and larva upon decomposing carcasses. Our aims have been to identify the responsible compounds in the odours of the carcass that are important for the attraction of the beetles. Furthermore, we have studied sex- and age-related differences in beetle attraction and tested whether the hide beetle can distinguish between various stages of decomposition by means of the emitted odours. Headspace collection of volatiles released from piglet carcasses (bloated stage, post-bloating stage, advanced decay and dry remains), coupled gas chromatography-mass spectrometry (GC-MS), gas chromatography with electroantennographic detection (GC-EAD) and bioassays were conducted to identify the volatiles responsible for the attraction of the beetles. Freshly emerged male beetles were attracted by the odour of piglets in the post-bloating stage (9 days after death; T(mean) = 27 °C) and the EAD-active compound benzyl butyrate. Statistical analysis revealed a higher relative proportion of benzyl butyrate in the odour bouquet of the post-bloating stage in comparison with the other stages. We therefore conclude that this compound plays an important role in the attraction of hide beetles to carcass odour. This underlines the potential use of D. maculatus for the estimation of the post mortem interval. The decomposition stage at which the female beetles are attracted to the odour of a cadaver remains unknown, as does the nature of this attraction. Pheromones (sexual or aggregation pheromones) might play an essential role correlated with their attraction to carrion and consequently with their attraction to the substrate for mating and ovipositioning.     

Protective Factors at School: Reciprocal Effects Among Adolescents’ Perceptions of the School Environment,Engagement in Learning,and Hope

Although some research suggests that schools can be a source of protective factors for students, the processes by which school environments impact students’ behavior, performance and adjustment over time are not clear. Guided by both self-determination theory and hope theory, this article evaluated reciprocal effects among adolescent perceptions of the school environment, engagement in learning, hope, and academic achievement. Using a sample of 423 students (M age 15.72 years; 46.7% female; 77.6% white; 30.9% eligible for FRPL) from five small secondary schools in the upper Midwest, students’ perceptions of the school environment were linked to engagement in learning, which, in turn, was linked to change in academic achievement and hope over the span of 1 year. Evidence was found for reciprocal links between earlier levels of engagement and hope and later perceptions of the environment. These results suggest that the school environment represents a potential leverage point for educational reform, and interventions that target students’ perceptions of autonomy, teacher/peer support, and goal orientation may be able to promote engagement, hope, and academic achievement. In addition, such changes may create a positive feedback loop in which change in academic performance and adjustment accelerate over time.     

Risk adjustment and risk equalization: what needs to be done?

In this paper, we first deal with the rationale of risk adjustment and risk equalization in health insurance markets. Then we discuss the state of the art concerning the application of risk adjustment and risk equalization in practice. Finally, we focus on: What needs to be done?     

Conceptions of liberty during the Dutch revolt 1555–1590

Traditionally considered as selfish usurpers of the nation's will on the eve of the Revolution, members of the Ancien Régime parlements resorted to a falsely pre-revolutionary language has long convinced historians in their interpretations. Beyond the semantics associated with the remonstrance – a genre that is suggested here –, this paper wishes to re-insert the parliamentary dialectics against these arbitrary orders of the years 1787–88 into a broader socio-cultural field. Our aim is to show that what was at stake when dealing with the ‘sealed’ letters hinged around power and contestation within the public opinion expressed through various speeches in the Paris and provincial parliaments. The unanimous questioning of these lettres de cachet obviously concealed numerous differences and often illustrated confusion between the pre-revolutionary intentions, as expressed in leaflets, and the parliamentary speeches strongly intent on defending identity privileges. The parlements were, however, the driving force of the campaign against lettres de cachet and thus introduced the French people to what we can call rather a grammar of resistance. If they were the object of general denunciation right from the calling of the Etats généraux in July 1788 as if they had betrayed the Nation, this was because the French people were at the same time experiencing events that suddenly altered their identity along with their contesting of absolutism.     

西方霸权的竞争者:过去与现在——作为一种全球治理视角

近年来，人们常常听到对于中国何时能超过美国成为世界头号经济体的各种预测。高盛首席经济学家吉姆·奥尼尔在最近的一次评估中认为，就目前的增长率而言，中国将在2027年超过美国。就在同一年，金砖四国GDP总和将超过目前的七国集团。     

Contested hybridization of regulation: Failure of the Dutch regulatory system to protect minors from harmful media

The hybridization of regulatory modes and instruments is currently a popular way to improve public regulation. However, it is still unclear whether combinations of hard law and soft law, co-regulation, and legally enforced self-regulation really make regulation more effective. Using the analytical framework of the “really responsive regulation” approach, in this article we explore effectiveness problems in a hybrid regulatory system that tries to protect minors from harmful media. In our analysis of low compliance rates in the context of system failures, we argue that effectiveness problems seem to arise from poorly informed staff members, lack of internal and external controls, low rule enforcement, insufficient overlap between public and private interests, poor social responsibility in the Dutch media sector, deficiencies in the institutional framework, an inconsistent regulatory strategy, and inadequate responses from responsible regulators. Furthermore, based on our case study we argue that institutional dynamics of standard-setting activities can be detrimental to regulatory goal achievement if there is no compensation at the systemic level. Ongoing “regulatory care” through control, corrective responses, and rule enforcement seems to be crucial for a hybrid regulatory system to perform well.