Evidence of mephedrone chronic abuse through hair analysis using GC/MS

Mephedrone is a synthetic derivative of cathinone which is becoming more common on the recreational drug market. Several intoxications following mephedrone abuse have been reported though published papers have focused essentially on analytical approaches for biological fluids and only one has involved a hair sample. After the development and validation of a new method, the first series of positive results for mephedrone in hair specimens is reported here. After decontamination of the hair strand in methylene chloride, hair segments were cut into small pieces with scissors, weighed and incubated overnight in Soerensen buffer pH 7.0 in the presence of deuterated 3,4-methylenedioxymethamphetamine (MDMA) at 40°C. The incubation medium was extracted using ethyl acetate after alkalinisation with 1N sodium hydroxide (NaOH). Before injection, the dry extract was derivatized using a mixture of heptafluorobutyric anhydride/ethyl acetate (100:50, v/v), evaporated and dissolved in ethyl acetate (25μl). After introduction of 1μl of the extract onto a splitless injector, chromatographic separation was achieved on a HP 6890 gas chromatograph equipped with a 5-MS capillary column. Detection was achieved in single ion monitoring mode (m/z 254-119-210 for mephedrone, m/z 258-213 for MDMA-d5) using a 5973 MSD operating in electron impact mode. Sixty-seven hair specimens were tested for mephedrone. Thirteen of them were found positive for mephedrone with concentrations ranging from 0.2 to 313.2ng/mg with a mean concentration of 26.8ng/mg. It was difficult to compare our findings due to a lack of reference data, nevertheless mephedrone seems well incorporated into hair (concentrations in the ng/mg range) like other stimulant drugs such as amphetamines or cocaine. The aim of this work was to develop a specific and accurate method for mephedrone analysis in hair specimens and its application to a large number of samples (n=67). The developed analytical method appears sensitive enough to reveal occasional to regular use of mephedrone.     

Killing the Zombie Peace and Building a New Movement

The prospects for a just and sustainable peace are dire. The Oslo framework and the two-state solution are no longer fit for purpose (if indeed they ever were). And yet it is entirely possible that the current situation could limp on for a while longer – like a zombie that refuses to die. This short opinion piece argues that, in this context, a new movement and a new strategy are urgently required.     

Fluorescence Imaging of Posterior Spiracles from Second and Third Instars of Forensically Important Chrysomya rufifacies (Diptera: Calliphoridae),

Entomological protocols for aging blowfly (Diptera: Calliphoridae) larvae to estimate the time of colonization (TOC) are commonly used to assist in death investigations. While the methodologies for analyzing fly larvae differ, most rely on light microscopy, genetic analysis, or, more rarely, electron microscopy. This pilot study sought to improve resolution of larval stage in the forensically important blowfly Chrysomya rufifacies using high‐content fluorescence microscopy and biochemical measures of developmental marker proteins. We established fixation and mounting protocols, defined a set of measurable morphometric criteria and captured developmental transitions of 2nd instar to 3rd instar using both fluorescence microscopy and anti‐ecdysone receptor Western blot analysis. The data show that these instars can be distinguished on the basis of robust, nonbleaching, autofluorescence of larval posterior spiracles. High‐content imaging techniques using confocal microscopy, combined with morphometric and biochemical techniques, may therefore aid forensic entomologists in estimating TOC.     

A comparison of seclusion rates between intellectual disability and non-intellectual disability services: the effect of gender and diagnosis

Introduction: The use of seclusion as a means of managing the extreme behaviours forensic patients in secure settings is a controversial yet often common practice, despite there being little evidence that seclusion as a practice has any significant therapeutic value for the patient. The aim of this study was to explore the use of seclusion and whether this differs as a function of gender and diagnosis across secure services. Method: This study collated data from 11 medium and low secure hospitals that admit male and female patients, with some services providing services for patients with intellectual disability (with or without co-morbid disorders), and others for patients with mental illness and/or personality disorder only. Results: Both gender and diagnosis were associated with differential seclusion rates. Seclusions were three times longer for patients in the non-ID compared to the ID service. Male seclusions (for any diagnosis) were around twice as long as those in female services. Female ID patients spent significantly less time in seclusion compared to other groups. Female ID was associated with two to three times the number of seclusion events per patient compared to other groups. No statistically significant association between the type of service and the reason for a patient being secluded. Conclusions: A range of organisational factors that determine the use and duration of seclusion are cited and merit further exploration. High rates of psychiatric co-morbidity and the complexity of patients admitted to services may also mediate risk and use of seclusion. The study supports the use of early intervention techniques and the adoption of positive behaviour support.     

Party Government and the "Cohesive Power of Public Plunder"

We argue that party government in the U.S. House of Representatives rests on two pillars: the pursuit of policy goals and the disbursement of particularistic benefits. Existing theories of party government argue that the majority party in the House is often successful in biasing policy outcomes in its favor. In the process, it creates "policy losers" among its own members who nevertheless support their party on procedural votes. We posit that the majority party creates an incentive for even the policy losers to support a procedural coalition through judicious distribution of particularistic benefits that compensates policy losers at a rate commensurate with the policy losses that they suffer. We evaluate our theory empirically using the concept of "roll rates" in conjunction with federal domestic outlays data for the period 1983–96. We find that, within the majority party, policy losers are favored in the distribution of "pork barrel" spending throughout this period.     

The Fourth Indo-China War

Against the background of twentieth-century military conflict in Asia, the article concentrates on China’s contemporary relationships with outlying states, regions and provinces. Employing a version of Thomas Malthus’s political economy, we argue that population wars are an important, if often disguised, future of modern foreign relations. Through an examination of a various examples but specifically Tibet, Vietnam and Uyghurs in Xinjiang province, the article considers the current prospects of sinicization by demographic means. We conclude by describing ‘red capitalism’ in Asia as a combination of authoritarian states plus economicv success within the framework of a tributary Han civilization.     

The perceptions of the European Union among tertiary education students in Singapore

Students from the three main universities in Singapore were surveyed in the third quarter 2008 to assess their perceptions and knowledge of Europe/the European Union. This survey complements and expands upon that done in 2006 by the National Centre for Research on Europe (NCRE) which was supported by Asia–Europe Foundation. The student survey showed that this important age and education cohort had a middling to low assessment of the EU in its importance for Singapore, an assessment which was much lower than the objective view of the relation (in terms of trade and the EU as a dialogue partner) would warrant. The sources of this perception were examined, and it was found that there was no immediate correlation between level of assessment of Europe/the EU and: gender, nationality, year of study, subject of study or frequency of accessing the local media for international news. Therefore, such perceptions can be assumed to derive from sporadic, ad hoc intangible contacts and fleeting impressions rather than through formal education, the media and specific, focussed and localised EU-related outreach programmes.

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Features of smuggling in Wadi Khaled,Lebanon

Through survey research, we investigate the potential socio‐economic impact of tighter Lebanese–Syrian border controls on the impoverished community of Wadi Khaled. We demonstrate that, given the lack of Lebanese infrastructure and meaningful development in the region, residents of Wadi Khaled rely on illegal cross-border traffic to meet basic needs, including the purchase of foodstuffs, building materials, medicine and fuel. Our survey revealed high levels of food insecurity and poverty and determined important socio-demographic associations with smuggling. One of the most closely associated characteristics with support for smuggling behaviour was one's religious background, which we believe to be a function of Lebanon's consociational political system. The wellbeing of Wadi Khaled residents, we argue, demands that any effort to combat smuggling entail improving social support for the community and facilitating access to Lebanese markets and infrastructure.     

Moving beyond the socialization hypothesis: The effects of maternal smoking during pregnancy on the development of self-control

Purpose

Gottfredson and Hirschi, in A General Theory of Crime, argue that the primary source of self-control is parental socialization. Specifically, parents who fail to supervise their children, to recognize their child's deviant behavior, and to punish such behavior are more likely to raise children with lower levels of self-control. Recent empirical research, however, has broadened the explanatory factors to include sources within schools, neighborhoods, and individual factors as significant contributors to the development of self-control. This study proposes that maternal smoking during pregnancy places additional limits on the development of self-control.

Methods

Using a subsample of the National Longitudinal Study of Youth (N = 542), we provide a comprehensive investigation of the variety of sources of self-control to include both individual and environmental covariates.

Results

Results indicate that maternal smoking during pregnancy significantly impacts the development of self-control net of parental, neighborhood, and school socialization. We also found that individual sources of self-control significantly vary across race and neighborhood context.

Conclusions

The sources of self-control are more complex than socialization from parents, schools, and within neighborhoods occurring in childhood and adolescence.     

The relationship of violent fathers, posttraumatically stressed mothers and symptomatic children in a preschool-age inner-city pediatrics clinic sample

This study aims to understand if greater severity of maternal posttraumatic stress symptoms (PTSS), related to maternal report of interpersonal violence, mediates the effects of such violence on (a) child PTSS as well as on (b) child externalizing and internalizing symptoms. Study participants were mothers (N = 77) and children 18 to 48 months recruited from community pediatric clinics. Data were analyzed continuously via bivariate correlations and then multiple linear regression. Post hoc Sobel tests were performed to confirm mediation. Paternal violence accounted for 15% of the variance of child PTSS on the PCIP-OR (β = .39, p ≤ .001). While the child's father being violent significantly predicts child PTSS related to domestic violence, as mentioned, when maternal PTSS is included in the multiple regression model, father's being violent becomes less significant, while maternal PTSS remains strongly predictive. Sobel tests confirmed that maternal PTSS severity mediated effects of paternal violence on clinician-assessed child PTSS as well as on maternal report of child externalizing and internalizing symptoms. When presented with a preschool-aged child who is brought to consultation for behavioral difficulties, dysregulated aggression, and/or unexplained fears, clinicians should evaluate maternal psychological functioning as well as assess and treat the effects of interpersonal violence, which otherwise may be avoided during the consultation.