Systematic differences in electropherogram peak heights reported by different versions of the GeneScan software

DNA profiling using STRs on the 310 and 3100 Genetic Analyzers routinely generates electropherograms that are analyzed with the GeneScan software available from the instrument's manufacturer, Applied Biosystems. Users have been able to choose from three different smoothing options that have been known to result in significant differences in the peak heights that are reported. Improvements in the underlying algorithm of the most recent version of the software also result in significant and somewhat predictable differences in peak height values. Laboratories that have performed validation studies using older versions of GeneScan should either reanalyze the data generated in those validation studies with the newest version of the software or otherwise take into consideration the systematically higher peak height values obtained as they begin following the recommendation of the manufacturer and use the new algorithm.     

农村村民自治的理论溯源

有学者认为,村民自治作为一种"基层群众性自治",无论是在马恩列斯著作中,还是在毛泽东全集里,均找不到它的理论源头.本文作者认为,马克思主义经典作家提出的人民自治理论和毛泽东大力发展农村民主建设的思想,为我国实行村民自治提供了重要的理论依据.同时,村民自治又是当代中国领导人根据中国国情所进行的巨大理论创新,是马克思主义人民自治理论在中国的新发展.     

The impact of genetic enhancement on equality

There apparently is a genuine possibility that genetic and non-genetic mechanisms eventually will be able to significantly enhance human capabilities and traits generally. Examining this prospect from the standpoint of equality considerations is one useful way to inquire into the effects of such enhancement technologies. Because of the nature and limitations of competing ideas of equality, we are inevitably led to investigate a very broad range of issues. This Article considers matters of distribution and withholding of scarce enhancement resources and links different versions of equality to different modes of distribution. It briefly addresses the difficulties of defining "enhancement" and "trait" and links the idea of a "merit attribute" to that of a "resource attractor." The role of disorder-based justifications is related to equality considerations, as is the possibility of the reduction or "objectification" of persons arising from the use of enhancement resources. Risks of intensified and more entrenched forms of social stratification are outlined. The Article also considers whether the notion of merit can survive, and whether the stability of democratic institutions based on a one-person, one-vote standard is threatened by attitude shifts given the new technological prospects. It refers to John Stuart Mill's "plural voting" proposal to illustrate one challenge to equal-vote democracy.