Quantitative and qualitative analysis of DNA extracted from postmortem muscle tissues

DNA extracted from 33 postmortem muscle specimens was analyzed using MZ 1.3, a hypervariable minisatellite probe, as well as locus-specific minisatellite probes (g3, MS1 and MS43). After storage at -25 degrees C for 10 months, DNA from all the samples was partially (approximately 21% of total DNA) degraded even when autopsy was performed 1 day postmortem. However, more than 90% of DNA samples up to at least 3 days postmortem were suitable to obtain good restriction fragment length polymorphism (RFLP) patterns. When small strips of specimen were stored for 8 days at room temperature in moist chambers, approximately 42% of total DNA was degraded. Only 30% of these DNA samples still showed good RFLP patterns. However, no obvious relation between qualities of DNA analyzed by detection of RFLP and quantities of total and high-MW DNA became apparent. A case of familial relationship was ascertained by DNA fingerprints. Since DNA of good quality can be recovered from muscle tissues in large quantities, DNA extraction from muscle tissues and detection of RFLP patterns should be very useful for individual identification in autopsy cases.     

HIV-1- prevalence among drug deaths in major cities of central and northern Europe.

Since 1985, a number of Institutes of Forensic Medicine in Germany have cooperated in a multicenter study, to provide a constant monitoring of HIV-1-prevalence among drug related deaths. In 1990/91, the Institutes in Copenhagen, Stockholm, Vienna and Zürich also participated in this study. HIV-1-prevalence is decreasing in the German cities, whereas the epidemiological development is not uniform in the other major cities. Regional differences are obvious. In 1991, the prevalence rates were as follows: Berlin 15% (n = 220), Hamburg 4% (n = 179), Frankfurt 17% (n = 167), Munich 9% (n = 136), Stockholm 10% (n = 79), Copenhagen 14% (n = 130), Vienna 20% (n = 56), and Zürich 23% (n = 84).     

Policy research and analysis: an empirical profile, 1975–1980

A content analysis was conducted on 181 randomly sampled articles published in nine leading social policy journals from 1975 through 1980. The purpose of the study was to obtain a methodological and substantive profile of the state of the art of the policy sciences. Results indicate the existence of two prevailing types of policy analysis: quantitative-empirical and rhetorical-discussive.The positions expressed in this article are those of the authors and do not necessarily represent the views of the National Science Foundation, the University of Tennessee-Knoxville, or Applied Science Associates, Inc.     

EVALUATION RESEARCH AND POLITICAL SCIENCE: AN ARGUMENT AGAINST THE DIVISION OF SCHOLARLY LABOR

Political science might have been the birthplace of evaluation research, but it has instead been unreceptive to it for a number of reasons. Hofferbert's suggestion that political scientists become involved by studying the impact of policy on democratic processes does not take into account the ferment that has been taking place in the field of evaluation. Political scientists should not conduct evaluation studies using the same methodology they normally use because these may not produce the kind of information needed for improving policies or programs. A disciplinary division of labor is impractical for a number of reasons. Instead, they should use a policy sciences framework, which contains normative elements and focuses on potentials for change, among other things.     

Enucleation in psychosis associated with aqueductal stenosis

Reports of self-enucleation are frequent in medical literature, but cases of enucleation towards another are rare. We report the case of a man, 20 years of age, who suffered from psychosis with hydrocephalus and aqueductal stenosis that required a forensic psychiatric investigation to ascertain whether he was of unsound mind when he assaulted and enucleated the right eye of an officer and led to the surgical enucleation of the victim's left eye. Based on his clinical interviews and hospitalization record, we conclude that at the time of the assault, he was suffering from a delusional disorder with religious and demonic content, visual and auditory hallucinations, illusion phenomena, delusional interpretations, imaginative elements, a feeling of terror, and command hallucinations that compelled him to perform the act of aggression.     

Twelve tongues, one voice: An evaluation of European political cooperation

Abstract. Traditional integration theories disagree over the scope of the main foreign policy instrument of the European Union (EU), the so-called European Political Cooperation (EPC). While intergovernmentalism suggests that EPC actions are weak, neofunctionalism maintains that cooperation within the EPC framework is characterised by strong measures. In this article, we present a game-theoretic and statistical analysis of these conflicting propositions and show that European foreign policy making is much more diversified than predicted by the predominating theoretical approaches. A signalling game demonstrates that the exploitation of uncertainty by a possible profit-seeker outside the organisation can cause inadequate EPC decisions. The formal model also explores the extent to which joint interest in closer foreign policy coordination can help to overcome diverging national policy preferences. The empirical test of some game-theoretic hypotheses shows that European foreign policy making has become more intensive. The increasing number of declarations is, however, also a sign of the proliferation of non-committing statements. Logit regressions reveal a close relationship between the economic salience of an EPC target nation to the European Union and the intensity of an EPC reaction.     

Public attitudes toward economic conditions and their impact on government behavior

This article reviews extant studies of the impact of economic conditions on government electoral behavior in the Western democracies. Three conclusions are reached: (1) in representative democracies there exists a consistent relationship between the economic situation and citizen evaluation of government; (2) the proposition that governments are interested in achieving their selfish goals in elections fares well compared with the competing proposition that governments are interested in the state of the economy as such; and (3) governments and voters are not the only actors in politico-economic decisions: bureaucracies and interest groups may make government incapable of changing its policies quickly in the face of stiff resistance from this multitude of other actors. Their inclusion in relevant models is a necessary next step in research designed to understand better the functioning of modern democratic societies.This paper was written while the author was at GSIA, Carnegie-Mellon University.