A capillary zone electrophoresis (CZE) method was developed for the analysis of amphetamine and 13 amphetamine analogues. A full factorial design was used to screen for important design variables (i.e. carrier electrolyte concentration, pH, and separation temperature), and a modified simplex was employed in a final optimisation step. The resolution values of the target compounds were used as responses in the screening and optimisation phases. This approach made it possible to control the effects of the design variables on the separation of the target compounds. The best results were obtained using a 100mM Tris/phosphate buffer (pH 3.1) at a separation temperature of 10 degrees C, and the analysis time was 23 min under these conditions. After slight modification, the method also enabled baseline resolution of the most commonly encountered amphetamine derivatives, as well as cocaine and heroin, within 7 min. There was a linear relationship between peak area and concentration for all substances, with correlation coefficients in the range of 0.9975-0.9999. Moreover, the technique was repeatable and exhibited relative standard deviation (R.S.D.) values in the ranges of 0.01-0.11% and 0.54-1.60% for relative migration time and corrected peak area, respectively. Lastly, the method was successfully applied to analyse street samples. 相似文献
The mentally disordered offender falls into the "no man's land" between prison and mental health systems. A number of reasons are given to explain why mental health service to this special group is in crisis again, and to lay the base for understanding the advantages and disadvantages of five different models of service delivery. The authors conclude by favoring small psychiatric units attached to major prisons. 相似文献
This study examined whether location and type of juvenile court impacted processing for juveniles in a Midwestern state. 1 For the analysis, the author used qualitative data. This article was built on the opinions and observations of those who work in the juvenile justice system on a daily basis. The author observed juvenile courts and interviewed judges, prosecutors, and defense attorneys. The information contained herein verifies the differences between rural and urban juvenile justice practice and procedure. The results of this study also revealed that processing varies across jurisdictions and type of court in the juvenile justice system. 相似文献
Drawing on empirical data gathered from discussions with executive directors of NGOs in Ghana, this paper critically analyses the complex multi-tier relationships between NGOs and their donor partners and how these affect outcomes of their development projects in Ghana. The paper discusses how experiences with funding agencies inform crucial shifts in NGO programming for poverty alleviation. This paper argues that, given their (NGOs') peculiar positioning in development practice, a critical appraisal of power dynamics central to NGO operations (such as funding and ownership of development projects) is crucial to proposing new strategies of engagement with NGO activity in Africa.
Autonomie et indépendance sur le plan des politiques en Afrique : un bilan des défis de développement pour les ONG
Sur la base de données empiriques recueillies à partir de discussions avec des directeurs exécutifs d'ONG au Ghana, cet article analyse dans une optique critique les rapports complexes multi-niveaux entre les ONG et leurs partenaires bailleurs de fonds, et l'incidence qu'ils ont sur les résultats de leurs projets de développement au Ghana. Il traite de la manière dont les expériences avec des organismes donateurs façonnent des changements cruciaux dans la programmation des ONG en faveur de l'atténuation de la pauvreté. L'auteur soutient que, étant donné le positionnement particulier des ONG dans la pratique du développement, une évaluation critique de la dynamique de pouvoir centrale aux opérations des ONG (comme le financement et la propriété des projets de développement) est cruciale au moment de proposer de nouvelles stratégies en vue de la participation aux activités des ONG en Afrique.
Autonomía e independencia política en África: una revisión de los retos enfrentados por las ong en el desarrollo
Apoyándose en datos empíricos recabados a partir de diálogos sostenidos con los directores ejecutivos de ong en Ghana, el presente artículo analiza críticamente las relaciones complejas y de múltiples niveles que se establecen entre las ong y sus socios donantes. Del mismo modo, examina la manera en que dichas relaciones afectan los resultados obtenidos por sus proyectos de desarrollo en este país. Asimismo, el artículo revisa cómo las experiencias de las ong con las agencias de financiamiento, influyen en los cambios sustantivos detectados en los programas que han implementado para el alivio de la pobreza. El artículo sostiene que, dado el particular posicionamiento de las ong en la práctica del desarrollo, para proponer nuevas estrategias de involucramiento en las actividades que realizan en África, resulta crucial realizar una valoración crítica de las dinámicas del poder que se establecen en dichas actividades (por ejemplo, el financiamiento y el sentido de pertenencia de los proyectos de desarrollo).
Autonomia e independência de política na África: uma revisão dos desafios de desenvolvimento de ONGs
Baseando-se em dados empíricos coletados a partir de discussões com diretores executivos de ONGs de Gana, este artigo analisa de maneira crítica as relações complexas de vários níveis entre ONGs e seus parceiros doadores e como elas afetam os resultados de seus projetos de desenvolvimento em Gana. O artigo discute como as experiências com agências financiadoras influenciam mudanças cruciais em programas de ONGs para redução da pobreza. Este artigo argumenta que, tendo em vista o posicionamento peculiar (das ONGs) na prática de desenvolvimento, uma avaliação crítica da dinâmicas de poder central para operações de ONGs (tais como financiamento e posse de projetos de desenvolvimento) é crucial para se propor novas estratégias de engajamento com a atividade das ONGs na África. 相似文献
The Iraqi High Tribunal has been criticized on all sides forits failure to deliver fair trials. Many observers have advocatedan international or internationalized court instead. However,these alternatives, even if desirable, were outside the ambitof what was possible in post-war Iraq. Given that a domesticcourt was the only realistic option, much more help and supportshould have been given to it by the international community. 相似文献
Effort assessment is a relevant area in neuropsychological assessment. There are well-established self-report measures, such as the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) FBS Symptom Validity Scale (FBS; Lees-Haley, English & Glenn, Psychological Reports 68: 203-210, 1991) and MMPI-2 Response Bias Scale (RBS; Gervais, Ben-Porath, Wygant & Green, Assessment 14: 196, 2007). However, there is also a need for brief measures of symptom exaggeration. The Structured Inventory of Malingered Symptomatology (SIMS) appears to be a promising self-report measure of symptom validity (e.g., Smith & Burger, Academy of Psychiatry and the Law 25: 183-189, 1997). In order to understand the psychometric properties of the SIMS, a comprehensive item analysis was performed with the questionnaire. Items were removed due to invariable response or lack of relationship with the total SIMS. Receiver operating characteristics (ROC) curve analyses were completed using RBS and FBS Symptom Validity Scale (FBS) of the MMPI-2 with items grouping from the SIMS indices. The results found that limiting the number of items did not affect overall utility. The abbreviated indices on the SIMS had excellent discrimination with the neurologic impairment (NI) and affective disorder (AF) scales and good discrimination with psychosis (P) and amnesic disorder (AM) scales of the SIMS. The briefer measure allows for less time required to administer the measure, while still maintaining the integrity of the SIMS. 相似文献