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31.
Managing incidental findings in human subjects research: analysis and recommendations. 总被引:8,自引:8,他引:0
Susan M Wolf Frances P Lawrenz Charles A Nelson Jeffrey P Kahn Mildred K Cho Ellen Wright Clayton Joel G Fletcher Michael K Georgieff Dale Hammerschmidt Kathy Hudson Judy Illes Vivek Kapur Moira A Keane Barbara A Koenig Bonnie S Leroy Elizabeth G McFarland Jordan Paradise Lisa S Parker Sharon F Terry Brian Van Ness Benjamin S Wilfond 《The Journal of law, medicine & ethics》2008,36(2):219-48, 211
No consensus yet exists on how to handle incidental findings (IFs) in human subjects research. Yet empirical studies document IFs in a wide range of research studies, where IFs are findings beyond the aims of the study that are of potential health or reproductive importance to the individual research participant. This paper reports recommendations of a two-year project group funded by NIH to study how to manage IFs in genetic and genomic research, as well as imaging research. We conclude that researchers have an obligation to address the possibility of discovering IFs in their protocol and communications with the IRB, and in their consent forms and communications with research participants. Researchers should establish a pathway for handling IFs and communicate that to the IRB and research participants. We recommend a pathway and categorize IFs into those that must be disclosed to research participants, those that may be disclosed, and those that should not be disclosed. 相似文献
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Data are presented that indicate that the Southern region of the United States has a much higher arrest rate for drunkenness
than other regions of the country; that the state of Kentucky has a much higher arrest rate for drunkenness and for alcohol
offenses in total than even the Southern region; and that Madison County, Kentucky has much higher rates than even the state
of Kentucky. Data collected from court records in Madison County are then presented to describe the people arrested for alcoholrelated
offenses, the circumstances of their arrests, and the legal processing of their cases. Finally, speculative hypotheses for
the higher arrest rates for alcohol-related offenses in the South, in Kentucky, and in Madison County are discussed. 相似文献
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