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排序方式: 共有616条查询结果,搜索用时 15 毫秒
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Mulero JJ Chang CW Lagacé RE Wang DY Bas JL McMahon TP Hennessy LK 《Journal of forensic sciences》2008,53(4):838-852
DNA typing of degraded DNA samples can be a challenging task when using the current commercially available multiplex short tandem repeat (STR) analysis kits. However, the ability to type degraded DNA specimens improves by redesigning current STR marker amplicons such that smaller sized polymerase chain reaction (PCR) products are generated. In an effort to increase the amount of information derived from these types of DNA samples, the AmpFlSTR MiniFiler PCR Amplification Kit has been developed. The kit contains reagents for the amplification of eight miniSTRs which are the largest sized loci in the AmpFlSTR Identifiler PCR Amplification Kit (D7S820, D13S317, D16S539, D21S11, D2S1338, D18S51, CSF1PO, and FGA). Five of these STR loci (D16S539, D21S11, D2S1338, D18S51, and FGA) also are some of the largest loci in the AmpFlSTR SGM Plus kit. This informative nine-locus multiplex, which includes the gender-identification locus Amelogenin, has been validated according to the FBI/National Standards and SWGDAM guidelines. Our results demonstrate significant performance improvements in models of DNA degradation, PCR inhibition, and nonprobative samples when compared to the AmpFlSTR Identifiler and SGM Plus kits. These data support that the MiniFiler kit will increase the likelihood of obtaining additional STR information from forensic samples in situations in which standard STR chemistries fail to produce complete profiles. 相似文献
185.
Terance D. Miethe Timothy C. Hart Wendy C. Regoeczi 《Journal of Quantitative Criminology》2008,24(2):227-241
Derived from comparative approaches in both qualitative and quantitative research, the current study describes a simple exploratory
technique for the multivariate analysis of categorical data. This technique is referred to as the conjunctive analysis of
case configurations. After describing the logic and underlying assumptions of this conjunctive method, it is applied and illustrated
in the study of the federal sentencing of drug offenders. The relative value of this conjunctive approach for purposes of
exploratory data analysis and its overall utility as a method for confirmatory research are also discussed.
相似文献
Terance D. MietheEmail: |
186.
Timothy Amos 《Japan Forum》2015,27(2):213-234
This paper examines the historical transformation of urban outcaste areas into commoner neighbourhoods in early modern/modern Japan. Focusing on Tokyo's largest early modern outcaste community, an Asakusa area referred to as Shinchō (literally ‘Newtown’), the paper argues that a combination of factors, namely the historical processes of urbanization, status group consolidation, labour specialization, capital accumulation, and inter-status group network creation, created an elite stratum of neighbourhood residents who were reasonably well-integrated into the broader social and economic landscape of Edo by the late Tokugawa period. This movement towards desegregation in turn laid important foundations for the later administrative and conceptual incorporation of the Shinchō area into the broader metropolitan area. Wide-ranging entrepreneurial activities by members of this elite class in the early Meiji period further built on and propelled these changes although they also facilitated their eventual exodus from the community. Proto-capitalist development, however, while clearly capable of inducing an emancipatory effect for some key elites figures and while enabling the neighbourhood itself to become more closely identified with an emerging working class Asakusa, also worked to create a substratum of people subjected to a compounded form of discrimination that took place along both traditional status and newly emerging modern capitalistic lines. 相似文献
187.
Timothy Grose 《当代中国》2015,24(91):101-118
This Xinjiang Class is a four-year, national-level boarding school program established by the Chinese Communist Party (CCP) in the year 2000. The overarching aim of the program is clear: the CCP intends to train a core group of young Uyghurs who have internalized the ideals of the Party. This article, which is based on interviews and regular interaction with over 60 graduates of the Xinjiang Class, casts doubt on whether the boarding schools have been effective in ‘interpellating’ young Uyghurs as compliant members of the Chinese Nation (Zhonghua minzu). This article contends that Uyghur graduates of the Xinjiang Class have instead embraced a non-Chinese ethno-national identity—an identity bound by Central Asian and Islamic cultural norms—and have largely rejected the Zhonghua minzu identity. 相似文献
188.
Timothy J. Oliver 《The Political quarterly》2015,86(1):110-117
The Coalition took office in 2010 in what seemed to be a relatively benign foreign policy environment. Since then, the international environment has become far more treacherous and the government has considered war on humanitarian grounds on three occasions. In light of the silence of early Coalition documents on humanitarian intervention, together with the two parties’ different positions on the issue, this article assesses the extent to which the Coalition has adopted a distinctive approach to humanitarian intervention. In so doing, it evaluates the relative importance of Conservative and Liberal Democrat traditions in determining the direction of Coalition foreign policy. The article also considers whether there are other, more pertinent factors driving foreign policy, and offers an explanation for its relative isolation from coalition tensions. It concludes by reflecting on the likely future of humanitarian intervention after the May 2015 general election. 相似文献
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Timothy H. Goldsmith 《Society》2009,46(4):341-346
Biological science is deepening our understanding of life at a brisk rate, but interdisciplinary discourse is not keeping
pace. This essay offers an account of themes from evolutionary biology that can enrich appreciation of the complexities of
human behavior. Because this topic touches fields with different and more traditional perspectives, frictions and misunderstandings
exist, and I have employed examples from a single source in order to clarify the science. In her critique of evolutionary
psychology published in her book Scandalous Knowledge, the social theorist Barbara Herrnstein Smith has set forth views that are not in harmony with either evolutionary biology
or cognitive neuroscience. She asserts that specialized features of mental processing postulated by evolutionary psychologists
are without empirical justification; further, she dismisses the concept as embracing “non-physical mental organs.” There exist,
however, numerous examples of how brains process information in specific, functional ways, frequently characteristic of the
species. Furthermore, the charge of “non-physical mental organs” is not only wrong; it reveals a failure to recognize that
biology has two complementary modes of explanation. One is historical and addresses cause in terms of the historical course
of evolution and the process of natural selection. The other is proximate and includes many levels of analysis from molecular
to social. Because brains have evolutionary histories, the ‘function’ of a particular aspect of mental processing can have
a hypothetical explanation in terms of adaptive advantage that is independent of any knowledge of the underlying neural circuitry.
A computational model of the brain and representational processing of sensory information, however, are both compatible with
observed properties of neurons in the retina and visual cortex as well as with evolutionary processes. Finally, study of the
mental processes of non-human primates provides insight into the evolution of our own minds.
相似文献
Timothy H. GoldsmithEmail: |