Separation and structural characterization of the synthetic cannabinoids JWH-412 and 1-[(5-fluoropentyl)-1H-indol-3yl]-(4-methylnaphthalen-1-yl)methanone using GC-MS, NMR analysis and a flash chromatography system

The 'herbal highs' market continues to boom. The added synthetic cannabinoids are often exchanged for another one with a high frequency to stay at least one step ahead of legal restrictions. While most of these substances were synthesized for pharmaceutical purposes and have been described in the scientific literature before, others originate from clandestine laboratories supplying this lucrative market. In this paper, the identification and structure elucidation of two synthetic cannabinoids is reported. The first compound, 1-[(5-fluoropentyl)-1H-indol-3yl]-(4-methylnaphthalen-1-yl)methanone, was found along with AM-2201 in a 'herbal mixture' obtained via the Internet. For isolation of the substance from the mixture, a newly developed flash chromatography method was used providing an inexpensive and fast way to gain pure reference substances from 'Spice' products for the timely development or enhancement of analytical methods in the forensic field. The second substance, 4-fluoronaphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-412) was seized by German authorities as microcrystalline powder, making it very likely that it will be found in 'herbal mixtures' soon.     

Nontraumatic intracranial epidural hematoma: a case report

An outwardly mummified and inwardly badly decomposed body was found in a garage. At autopsy, no injuries were detected. Apart from coronary heart disease, with an old myocardial scar and a hepatic steatosis, the most striking finding was a large intracranial epidural hemorrhage situated at the left frontal lobe. As a relevant traumatic genesis could be ruled out, we deemed this a nontraumatic epidural hematoma. This finding is extremely rare. Several underlying disorders have been discussed as causes of spontaneous epidural hematomas. In this presented case, the authors discuss possible etiological factors.     

Mass spectral and NMR spectral data of two new designer drugs with an alpha-aminophenone structure: 4'-methyl-alpha-pyrrolidinohexanophenone and 4'-methyl-alpha-pyrrolidinobutyrophenone

This study presents and discusses the nuclear magnetic resonance (NMR) spectroscopic and mass spectroscopic data of the new designer drug 4'-methyl-alpha-pyrrolidinobutyrophenone (MPBP) and its homolog 4'-methyl-alpha-pyrrolidinohexanophenone (MPHP) which were seized in 2004 and 2000 in Germany for the first time. The structure elucidation of the aliphatic part of MPBP was carried out by product ion spectroscopy of the immonium ion formed after electron ionization as well as with 1H and 13C NMR. Product ion spectroscopy of immonium ions again proved to be a powerful tool to determine the structure of designer drugs and to distinguish between isobaric structures of the alkyl-amino moiety.     

Mehdi Hashemi and the Iran-Contra-Affair

In November 1986 a Lebanese newspaper revealed the secret arms-for-hostages deal between Tehran and Washington that subsequently became known as the Iran-Contra-Affair. The newspaper had been tipped off by friends of the Iranian radical Mehdi Hashemi who had been arrested shortly before in Iran. This article explores the link between the arrest of the ardent supporter of the then deputy leader Hossein-Ali Montazeri and the secret talks with the US government. The article will show that his arrest was not only an attempt of the then dominant faction around Ali Akbar Hashemi Rafsanjani to bring the future leader Montazeri under its control, but also an attempt to eliminate a rival actor opposing the rapprochement with the USA and threatening to disrupt the arms-for-hostages deal.     

Public pensions and immigration policy in a democracy

The paper analyzes the link between the public pension system and the immigration policy. In a pay-as-you-go system, the incentives for immigration vary significantly between individuals at different lifetime periods. In the framework of an overlapping generations model, we show that the median voter's choice in general leads to inefficient levels of immigration. The median voter neglects the effects of the externalities within the pension system on other generations. An immigration policy that is not affected by the median voter's choice but instead is constitutionally determined will avoid welfare losses. The expected lifetime income of each generation can be increased by applying a rule of steady immigration.     

Regulation vs Symbolic Policy-Making: Genetically Modified Organisms in the German States

Germany’s federal states can enforce stricter regulations on genetically modified organisms (GMOs) than does the national government. Empirically, the study analyses two outcomes at the state level: the symbolic accession to the GMO-free network, in which regional units mobilise against the EU’s regulatory approach, and hard GMO policies/regulations. Besides focussing on political parties and environmental interest groups, the article provides various additional theoretical explanations for the variation in outcomes. The research questions are the following: what conditions a state’s accession to the GMO-free network? What conditions a state’s adoption of GMO regulations? To assess these questions, the study employs fuzzy-set qualitative comparative analysis. One finding is that the inclusion of the Green Party in government is not a predominant condition for the adoption of regulations, but ministers affiliated with the Greens are dominant drivers of symbolic policy-making. The study reveals differing regulatory action by CDU/CSU ministers in the western and eastern states, which can be explained by the differing interests of farmers. Other findings reveal that SPD ministers regulated GMOs to much the same extent as CDU/CSU or Green ministers. Environmental interest groups were also found to have positively conditioned symbolic policy-making, having no effect, however, on the adoption of concrete regulations.     

鹅细小病毒VP2基因原核及真核表达载体的构建

将鹅细小病毒VP2基因克隆到原核表达载体 pPROEX HTb及真核转移载体pFASTBAC HTb中 ,重组真核转移载体在DH10BAC 中经转座作用 ,成功构建了表达VP2基因的原核表达载体pPROEX HTb VP2和杆状病毒表达载体BAC VP2。经限制性内切酶酶切及PCR分析 ,确定为阳性重组子