低氧和氧化应激中 NO介导培养神经元损伤机理的实验研究

目的探讨低氧、氧化应激中一氧化氮（NO）和氧自由基之间关系及其对培养神经元的损伤机理。方法对培养的新生大鼠神经细胞分别进行低氧、H2O2氧化应激处理和超氧化物歧化酶（SOD）抗氧化应激处理,用比色法等检测培养上清液中NO、丙二醛（MDA）、乳酸脱氢酶（LDH）和SOD含量变化指标。结果与对照组比较,低氧组和H2O2组的NO、LDH、MDA含量均显著增高,SOD含量显著降低,NO与SOD含量变化呈负相关关系。预先给予终浓度为200U/ml的SOD处理,可使神经细胞的NO、LDH和MDA释放量明显减少。各组间NO含量与LDH、MDA含量呈正相关关系。结论低氧、氧化应激促使神经元NO产生增多,NO有增加氧自由基对神经细胞的损伤作用。SOD具有清除氧自由基和减轻NO对神经元的损伤作用。     

An Empirical Study of Patent Grant Rates as a Function of Race and Gender

In this article we examine the rate at which patent applications are granted as a function of the inventor's race and gender. Empirical analysis of more than 3.9 million U.S. applications finds minority and women applicants are significantly less likely to secure a patent relative to the balance of inventors. Further analysis indicates that a portion of this bias is introduced during prosecution at the Patent Office, independent of the quality of the application. Mechanisms underlying these disparities are explored. The article concludes with a discussion of our results and their interaction with patent law, innovation policy, and employment trends.     

Labour Constitutions and Occupational Communities: Social Norms and Legal Norms at Work

This paper considers the interaction of legal norms and social norms in the regulation of work and working relations, observing that, with the contraction of collective bargaining, this is a matter that no longer attracts the attention that it deserves. Drawing upon two concepts from sociology – Max Weber's ‘labour constitution’ and Seymour Martin Lipset's ‘occupational community’ – it focuses on possibilities for the emergence, within groups of workers, of shared normative beliefs concerning ‘industrial justice’ (Selznick); for collective solidarity and agency; for the transformation of shared beliefs into legally binding norms; and for the enforcement of those norms. If labour law is currently in ‘crisis’, then a promising route out of the crisis, we argue, is for the law to recover its procedural focus, facilitating and encouraging these processes.     

The Aftermath of Cyberstalking: School,Work, Social,and Health Costs of Victimization

American Journal of Criminal Justice - The harms crime victims experience extend far beyond the initial victimization and can have severe negative impacts on daily life. Using data collected via a...     

Law Enforcement Lessons Learned from Hurricane Katrina

Major disasters represent infrequent events that often require response organizations to vicariously learn from the experiences of others in order to improve their operations. A primary mechanism for such knowledge diffusion is the different practitioner and empirical journals for the organizational fields that comprise disaster response. A review of the literature for the law enforcement field, however, reveals that little attention is given to how these organizations manage actual disasters. In particular, the presentation of organizational experiences, whether through case studies or other methodologies, is very limited in the practitioner and empirical literature of this field. This represents a considerable problem for improvements of disaster response operations given that law enforcement agencies represent a key component in such efforts. The research presented in this article is an effort to fill this knowledge gap and thereby facilitate organizational learning to improve future law enforcement disaster response activities. The authors traveled to Mississippi and Louisiana after Hurricane Katrina to examine the response efforts of state and local law enforcement agencies to the storm. The findings from this research are reported here in a lessons‐learned format to inform law enforcement disaster response policy.     

Regulatory dynamism of environmental mobilization in urban China

In China, urban middle class mobilization against potential pollution risk has become increasingly common. This article examines this phenomenon through a detailed case study of a 2009 anti‐waste incinerator campaign in the Panyu District of Guangzhou, which culminated in a sizeable public protest and government U‐turn. This episode revealed tension between the narrow, state‐centered regulatory model fixated on end‐of‐pipe pollution control, and a much broader decentered approach advocated – and practiced – by project opponents, which incorporated public consultation and much greater emphasis on upstream waste reduction and sorting. In the process, the Panyu campaign progressed beyond a case of “regulation by escalation,” whereby beneficial regulations are belatedly enforced following populist pressure. Instead, it transformed into an open dialogue between a plurality of actors, including citizens, journalists, experts, and officials, about what regulation should constitute and who should determine acceptable levels of risk. By focusing on the processes through which regulatory issues emerged and changed during the Panyu campaign, this article highlights the regulatory dynamism of environmental mobilization in a context of regulatory uncertainty, and campaigns against “locally unwanted land uses” more broadly.     

Ann Diamond on an Unlimited Constitutional Convention

Ann Diamond has argued that, unless it is called by all thestates, a convention held under Article V of the Constitutionof the United States would be limited to proposing piecemealchanges. Diamond's arguments are flawed. The power of the statesto call a convention to propose amendments is coequal with thepower of Congress to propose amendments and is subject to onlyone explicit limitation. The Convention of 1787 was not attendedby all the states, and it did not delimit two types of futureconventions. Diamond's analysis reflects extreme notions ofindividual state sovereignty that lack historical support andwould, in any event, unduly hobble the states as a whole.