A comparison of the characteristics of profiles produced with the AMPFlSTR SGM Plus multiplex system for both standard and low copy number (LCN) STR DNA analysis.

DNA STR profiles have been generated from 1 ng and low copy number (LCN) templates using 28 and 34 cycles of amplification, respectively. Characteristics which facilitate the interpretation of profiles, such as heterozygous balance, allelic dropout and stutter proportions have been quantified. We demonstrate that a reduction in DNA template coupled with an increase in amplification cycle number produces an increased rate of allelic dropout out which can be correlated to the peak areas of those alleles observed. In addition, the LCN conditions increase the degree of peak area asymmetry observed from heterozygotes and the size range of stutters. Analysis of the data allows us to develop sets of guidelines appropriate for interpreting both single and mixed DNA profiles.     

Exporting the Patriot Act? democracy and the ‘war on terror’ in the Third World

Since 2001 many countries have adopted anti-terrorism laws that limit civil liberties and expand law enforcement powers in the name of national security. Counter-terrorism legislation is promoted through several international channels, most notably the United Nations Counter-Terrorism Committee, but the USA is clearly seen as the driving force. This article examines the politics surrounding the recent development and implementation of anti-terrorism laws in the Third World and the implications for ongoing processes of democratisation. In some countries the adoption of anti-terrorism laws has provided leaders with the tools they need to silence critics and punish political opponents. In others the introduction of such bills has actually encouraged debate and fostered civil society activism, much of it anti-American in tone. In either setting the Bush administration's twin foreign policy goals of strengthening international security and promoting democracy may be creating more cynics than friends.     

Interpreting small quantities of DNA: the hierarchy of propositions and the use of Bayesian networks

The dramatic increase in the sensitivity of DNA profiling systems that has occurred over recent years has led to the need to address a wider range of interpretational problems in forensic science. The issues surrounding questions of the kind "whose DNA is this?" have been the subject of considerable controversy but now it is clear that the emphasis is shifting to questions of the kind "how did this DNA get here?" Such issues are discussed in this paper and new insights are provided by two particular recent developments. First, the notion of the "hierarchy of propositions" that has arisen from a project called Case Assessment and Interpretation (CAI) that has been running in the British Forensic Science Service (FSS). Second, a technique for drawing inferences in the face of many interacting considerations, known as "Bayesian networks"--or "Bayes' nets" for short--that has been the subject of an earlier paper in this journal (1). The discussion is carried out by means of case studies, based on actual cases. It is clear that, whereas the inference in relation to the source of the DNA in a crime sample might be overwhelmingly strong, the inference in relation to the propositions that a jury must consider relating to the identity of the actual offender may be much more tentative.     

Refugees: The security dimension

In the 1990s doors have been closing in the Western world against refugee claimants. Although there are multiple causes for declining generosity towards refugees, arguments that refugees pose security problems to host nations have been particularly prominent. An historical analysis reveals that the so‐called ‘golden age’ of postwar refugee settlement from the 1940s to the mid‐1970s was a by‐product of Cold War security and propaganda considerations. The end of the Cold War and the pressures of refugee movements generated by Third World and former Communist bloc conflicts has restructured Western refugee discourse. Refugees now tend to be seen as importers of external political conflicts into the West. At the same time growing European and North American resentment of ‘foreigners’ competing for declining job opportunities and reduced social services have encouraged anti‐immigrant political movements. By tightening barriers and controls over refugees on security grounds, Western governments are able to respond in part to these pressures. The Cold War policing and security alliance in Europe has been retooled to form the basis of a new post‐Cold War cooperation over immigration and refugee security, without the necessity of creating a new framework of supranational institutions.