Metabolite sensitivity in the methaqualone radioimmunoassay.

Recent literature reflects the increased use of RIA as a qualitative and quantitative tool. This study exemplifies the problems that may arise when this technique is used for quantitation. Caution must be exercised, and a physiological and toxicological understanding of each particular drug is essential to provide credible results. It is evident that the sensitivity and ease of the RIA method for methaqualone makes it invaluable as a screening test, but confirmation and quantitation of this drug must remain with those methods that can quantitate each metabolite.     

Some observations concerning blood morphine concentrations in narcotic addicts

Blood samples from deceased narcotic addicts were analyzed for morphine, and the results form persons who died from narcotic addiction were compared with those from homicide victims. In most instances morphine was detectable in both types of death, and usually the values obtained were less than 30 microgram/dl. Narcotic addiction deaths involving only morphine, or morphine plus a combination of ethanol, quinine, or diazepam (Valium), were also evaluated. In some cases high quantities of ethanol were present, and death could be attributed to the combined CNS depressant effects of morphine and ethanol. The quinine levels would not normally be considered toxic, however, and it could not be ascertained that the quantity of this drug present contributed to death. Diazepam was present in elevated concentrations, and its depressant effect may have been a factor in some narcotic addiction deaths.     

Book reviews

A. L. Meiendorf, Optimizatsiya khozyaistvennykh reshenii: metod analiza prirashchenii. Series: Aktual'nye problemy sel'skogo khozyaistva. Moscow: ‘Ekonomika’, 1976.

Oliver H. Radkey, The Unknown Civil War in Soviet Russia. A Study of the Green Movement in the Tambov Region, 1920–21. Stanford, Calif.: Hoover Institution, 1976. xiv+457 pp. $12.95.

Roy and Zhores Medvedev, Khrushchev—The Years in Power. London: OUP, 1977. xi+198 pp. £3.95.

Daniel F. Calhoun, The United Front: the TUC and the Russians, 1923–1928. Cambridge: CUP, 1976. 450 pp. £10.50.

Gabriel Gorodetsky, The Precarious Truce. Anglo‐Soviet Relations 1924–27. Cambridge: CUP, 1977. 289 pp. £9.00.

Herbert S. Dinerstein, The Making of a Missile Crisis: October 1962. Baltimore and London: Johns Hopkins UP, 1976. 302 pp. $14.95.

Donald R. Kelley, Kenneth R. Stunkel, Richard R. Wescott, The Economic Superpowers and the Environment: The United States, The Soviet Union, and Japan. San Francisco: W. H. Freeman & Co., 1976. 335 pp.

Fred Singleton (ed.), Environmental Misuse in the Soviet Union. New York and London: Praeger Publishers, 1976. xvii+103 pp. $13.50. £8.80.

Peter H. Juviler, Revolutionary Law and Order. Politics and Social Change in the USSR. New York: The Free Press, and London: Collier MacMillan, 1976. xii+274 pp. £11.05.

Richard Szawlowski, The System of the International Organizations of the Communist Countries. Leyden: A. W. Sijthoff, 1976. 322 pp.

Jürg Meister, Soviet Warships of the Second World War. London: Macdonald & Jane, 1977. 348 pp. £7.95.     

Book reviews

David Granick, Enterprise Guidance in Eastern Europe. A Comparison of Four Socialist Economies. Princeton, N.J.: Princeton UP, 1976. xvi+505 pp. £17.20 or £6.10 (paperback).

A. Zauberman, Mathematical Theory in Soviet Planning (Concepts, Methods, Techniques). London: OUP for the Royal Institute of International Affairs, 1976. xiv+464 pp. £17.00.

H. Gordon Skilling, Czechoslovakia's Interrupted Revolution. Princeton, N.J.: Princeton UP, 1976. 924 pp. £31.30 or £10.50 (paperback).

Alex Pravda, Reform and Change in the Czechoslovak Political System: January‐August 1968. Sage Research Papers in the Social Sciences, vol. 3, series No. 90–020 (Contemporary European Studies Series). Beverly Hills and London: Sage Publications, 1976. 96 pp. £1.30.

R. G. Gidadhubli (ed.), Fifty Years of Soviet Power—a Study of Social, Economic and Political Developments. Centre of Soviet Studies, University of Bombay, 1976. 295 pp. 29 rupees.

Occasional Papers, Centre for Soviet and East European Studies, Jawalharlal Nehru University, New Delhi, Nos. 2 and 3, 1976 (mimeographed).

Adam B. Ulam, A History of Soviet Russia. London: Martin Robertson, 1976. viii+312 pp. £5.00.

Olga A. Narkiewicz, The Green Flag: Polish Populist Politics 1867–1970. London: Croom Helm, 1976. 314 pp. £7.95.

Jacques Levesque, L'URSS et la révolution cubaine. Montreal: Presses de 1'Université de Montréal, 1976. 221 pp.

John B. Dunlop, The New Russian Revolutionaries. Belmont, Mass.: Nordland, 1976. 344 pp. $18.50.

Brian Hunter, Soviet‐ Yugoslav relations 1948–1972: a bibliography of Soviet, Western and Yugoslav comment and analysis. New York and London: Garland, 1976. 223 pp. $20.00.     

Excepted substances: a comparison of Federal and state laws.

A state law has placed an obligation on the criminal investigation laboratories to screen and quantitate all preparations, both pharmaceutical and illicit, that fall under the provisions of "Excepted Substances." Without complete screens on these preparations, there is room for erroneous indictments as well as possible acquittals on technicalities.     

The Prime Minister's mailbag

Abstract. This study is based on examination of a randomly selected sample of 2,150 letters representing all the mail received by Prime Minister Trudeau between February 1969 and June 1972. The object of the study was to ascertain the characteristics of the letter-writers and the nature of their concerns, arguments and strategies. Through interviews with the staff of the Correspondence Section of the Prime Minister's Office we were also able to discover how the mail is processed. This is described in the last section of our paper. As one might expect, the mail is unrepresentative of the regional, linguistic and class diversity of Canada. Metropolitan areas, rich provinces and English-speakers are over-represented, as are people who have access to typewriters. There is, however, a sizable group of letters from the very poor who write the Prime Minister to complain of their victimization by government bureaucracy or by life in general. These letters are personal and apolitical and approach the Prime Minister in a deferential manner. They appear to us to be carefully and sympathetically answered, and to be probably effective in rectifying small problems. The bulk of the mail is policy-oriented, but probably not effective in influencing policy. Public attention to policy, as expressed in the mail, is extremely transitory and focuses particularly on topics with strong emotional content or on those affecting economic welfare. The mail seems only weakly related to the government's own policy priorities. Sommaire. Cette étude est fondée sur un échantillon de 2,150 lettres tirées du courrier par le premier ministre Trudeau entire février 1969 et juin 1972. Nous avons voulu identifier les catégories de personnes qui s'adressaient au premier ministre, et déterminer le but de leur correspondence et la nature de leur argumentation etc. Nous avons interviewé le personnel de la section de la correspondance du cabinet du premier ministre pour connaître la procédure de réponse à ce courrier. Nous avons constaté que le courrier n'est pas représentatif de la diversité régionale, culturelle et sociale du pays. Les plus fortunés, les habitants des grandes villes, et les habitants des provinces sont surreprésentés. II y a, cependant, une proportion assez élevée de lettres venant d'économiquement faibles qui se plaignent au premier ministre de leur traitement par la bureaucratic ou de la vie en générate. Leurs problèmes sont formulés en termes personnels, et ces personnes s'adressent au premier ministre respectueusement. Les réponses à ces lettres nous paraissent sympathiques et souvent efficacies quant au redressement des plaintes. Le gros du courrier concerne l'orientation de la politique mais son influence est sans doute limitée. L'attention du public à l'égard de la politique gouvernementale est conditionnée par les évènements, en particulier les évènements à contenu émotif ou ceux qui touchent de près le bien-être des correspondants. Ce courrier ne se réfère que très indirectement aux priorités politiques du gouveniement.