Virtopsy: postmortem minimally invasive angiography using cross section techniques--implementation and preliminary results

Postmortem investigation is increasingly supported by Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). This led to the idea to implement a noninvasive or minimally invasive autopsy technique. Therefore, a minimally invasive angiography technique becomes necessary, in order to support the vascular cross section diagnostic. Preliminary experiments investigating different contrast agents for CT and MRI and their postmortem applicability have been performed using an ex-vivo porcine coronary model. MSCT and MRI angiography was performed in the porcine model. Three human corpses were investigated using minimally invasive MSCT angiography. Via the right femoral artery a plastic tube was advanced into the aortic arch. Using a flow adjustable pump the radiopaque contrast agent meglumine-ioxithalamate was injected. Subsequent MSCT scanning provided an excellent anatomic visualization of the human arterial system including intracranial and coronary arteries. Vascular pathologies such as calcification, stenosis and injury were detected. Limitations of the introduced approach are cases of major vessel injury and cases that show an advanced stage of decay.     

One hundred seventy two deaths involving the use of oxycodone in Palm Beach County

Oxycodone is a potent semi-synthetic narcotic prescribed for the management of pain. Previous investigators have reported that the abuse of oxycodone is most frequently seen in conjunction with the abuse of other drugs, although fatalities have been reported with oxycodone alone. We undertook a retrospective review of cases investigated by the Palm Beach County Medical Examiner's Office in which postmortem toxicologic studies indicated the presence of oxycodone. A total of 172 consecutive cases were studied, including 18 in which death was attributed to oxycodone toxicity, 117 to combined drug toxicity, 23 to trauma, 9 to natural causes and 5 to another drug or drugs. The postmortem blood concentrations of oxycodone overlapped among the groups. The mean blood oxycodone concentration among the cases of oxycodone toxicity was 0.69 mg/L, combined drug toxicity 0.72 mg/L and trauma 0.62 mg/L. Concentrations were lower in cases of deaths attributed to natural causes and to another drug or drugs (mean each 0.087 mg/L). Benzodiazepines, detected in 96 cases, were the most common co-intoxicants in the cases of combined drug toxicity, followed by cocaine, which was found in 41. The most frequently encountered benzodiazepine was alprazolam. This study confirms that deaths in which oxycodone is a factor are most commonly cases of combined drug toxicity. The high incidence of alprazolam as a co-intoxicant has not been previously recognized.     

Incorporating Equity into International Water Agreements

River basins have provided resources for the advancement of human civilization from the earliest historic times. With river basin development has also come conflict, particularly in the past century. In response, the international community has developed generalized, global principles for the equitable allocation of water resources between nation-states, most notably through the 1997 United Nations Convention on the Law of the Non-Navigational Uses of International Watercourses. These principles, however, have rarely been explicitly put into practice. To resolve or avert conflict in the world's 261 international river basins, riparian nations have instead relied upon treaties that incorporate basin-specific needs and conditions and define equity at the most local level. An examination of the progression of geographic thought on river basin development reveals a spatial focus that has not evolved beyond the basin and landscape scales. The absence of theoretical underpinnings for global frameworks may explain why riparian nations have not widely adopted general principles for the equitable allocation of water resources in actual treaty practice.     

Sudden unexpected death due to a previously undiagnosed plasma cell dyscrasia

The plasma cell dyscrasias are a diverse group of disorders characterized by the production of a clonal paraprotein. Sudden death is a recognized complication of the plasma cell dyscrasias, most commonly in individuals with cardiac involvement by amyloidosis. However, the current forensic literature has no reported cases in which sudden death resulted from complications of a plasma cell dyscrasia that was first diagnosed by postmortem histologic examination. We present the case of a woman whose sudden and unexpected death resulted from a seizure. Postmortem examination revealed no evidence of trauma or a grossly identifiable natural disease process that would have accounted for her death. However, microscopic and immunohistologic studies revealed a previously undiagnosed plasma cell dyscrasia, the clonality of which was determined by immunohistochemical studies for immunoglobulin light chains, that was not associated with amyloid deposition. This case elucidates a previously unrecognized cause of sudden unexpected death and illustrates the importance of microscopic studies in selected cases examined in medical examiner/coroner offices.     

Experimental tests for the validation of active numerical human models

The development of numerical human models is a topic of current interdisciplinary research. In the field of automotive safety these models can be applied for the optimization of protection systems. In forensic research human models can be used for the investigation of injury mechanisms and for the prediction and reproduction of injury patterns. However, up to now human models have been validated on the basis of PMHS tests without considering the effects of muscle activity. This paper shows two experimental volunteer test set-ups for the generation of experimental validation data. In a pendulum set-up the influence of muscle activity on the human kinematics was investigated. A drop test set-up was developed for the analysis of the effects of muscle activity on impact response characteristics of muscle tissue. Experimental results, presented in this paper, can be used for the validation and optimization of active numerical human models.     

Becoming an entrepreneurial university? A case study of knowledge exchange relationships and faculty attitudes in a medium-sized,research-oriented university

This paper seeks to contribute to the growing literature on the entrepreneurial university by mapping knowledge exchange relationships of entrepreneurial faculty in a comprehensive manner and also capturing faculty attitudes towards measures taken by the university administration to promote entrepreneurship. We report on an exploratory study of Sussex University, a medium-sized, research-oriented university, which launched technology transfer activities in the mid-1990s. Our results show that, in spite of a comparatively late start, a considerable number of researchers engage in knowledge exchange processes with industry and other non-academic partners. We present evidence that suggests faculty in the social sciences and humanities as well as natural sciences and engineering maintain links to industrial partners, including multinational corporations. Furthermore, our observations indicate that schools differ in the way their faculty engage in university–industry collaborations. Further differences can be observed with respect to faculty attitudes towards technology transfer and awareness of the university’s respective codes of practice.

Analysis of the First- and Second-Generation Raving Dragon Novelty Bath Salts Containing Methylone and Pentedrone

In recent years, a large number of designer drugs sold as “Bath Salts” have appeared on the market. In July of 2011, Raving Dragon Novelty Bath Salts was obtained over the Internet. This product became unavailable in October of that year coinciding with the DEA issuing a temporarily schedule of mephedrone, methylone, and MDPV. Four months later in February of 2012, a new product was released from the same company under the new name Raving Dragon Voodoo Dust. The contents of both products were identified using spectroscopy methods: nuclear magnetic resonance, infrared, UV–visible, tandem mass spectrometry, and high-resolution time-of-flight mass spectrometry. It was determined that Raving Dragon Novelty Bath Salts contained methylone. The replacement product Raving Dragon Voodoo Dust contained the unscheduled drug pentedrone. The Raving Dragon brand of products illustrates the rapid change of ingredients in these products to circumvent laws restricting availability, distribution, and use.     

Human capital and social capital in criminal networks: introduction to the special issue on the 7th Blankensee Colloquium

This essay and review on criminal network analysis provides an introduction to the special issue “Human Capital and Social Capital in Criminal Networks”. It traces the history of the application of network analysis in the study of organized crime since the early 1970s. It argues that while criminal network analysis has brought a new level of methodological rigor to the study of organized crime, a number of limitations have become apparent. These include the problem of missing data and the challenges encountered in adequately capturing latent structures, individual characteristics of network members and socio-ecological conditions.