GC/MS determination of pyrolysis products from diacetylmorphine and adulterants of street heroin samples

The inhalation of heroin vapors after heating on aluminium foil ("chasing the dragon") is gaining popularity nowadays among heroin users seeking to avoid the risks of parenteral drug administration. The heroin-smoking procedure was simulated under laboratory conditions by heating the samples on aluminium foil at 250 to 400 degrees C and collecting the vapors in a condenser trap. A total of 72 pyrolysis products of diacetylmorphine, street heroin, residues from aluminium foils used to smoke street heroin, typical by-products, and adulterants were detected by gas chromatography/mass spectrometry (GC/MS). About half of these compounds could be identified. Diacetylmorphine (base and salt) undergoes substantial to complete degradation. Some typical street heroin constituents, like morphine, codeine, acetylcodeine, papaverine, and caffeine, are rather heat-stable. Other compounds, like noscapine and paracetamol, are pyrolyzed to a greater extent. The principal chemical reactions leading to the formation of pyrolysis products are desacetylation, transacetylation, N-demethylation, O-methylation, ring cleavage and oxydation.     

What is the best sample for determining the early postmortem period by on-the-spot flow cytometry analysis?

The level of degradation of DNA as a means for determining the time of death has been proposed as a valid adjunct to the classic thanatochronologic methods. The twofold aim of this work was to determine which organ might reveal both a correlation between the percentage of degradation of the DNA and the time lapse since death, and would be easiest to sample and yield the most reproducible results even in technically unfavorable situations such as on-the-spot investigations at the scene of death. A comparison of the spleen, blood, and liver showed that hepatic tissue best meets these specific needs because it shows a virtually linear correlation between the time elapsed since death and the level of degradation of the DNA, and it can easily be sampled at the scene of death by use of a common biopsy needle.     

An unusual case of driving under the influence of enflurane

An unusual case of driving under the influence of the volatile anaesthetic enflurane is reported. A markedly affected anaesthetist was sniffing at an enflurane-moistened handkerchief before he crashed into a lorry at a red traffic light. In the blood sample enflurane (2.92 mg/l) as well as diclofenac (0.28 mg/l) and 4-aminophenazone (24.4 mg/l) were found. The way of driving and the accident and the deficiency symptoms could be explained by the central suppressing effects of enflurane. The physician was considered as impaired and not suitable to drive at the time of the incidence.     

A case of fatal hemorrhage in the cerebral ventricles following intravenous use of methamphetamine

We describe a case of massive hemorrhage in the cerebral ventricles, probably caused by methamphetamine abuse. A 44-year-old male was found dead in a prone position in a hotel room. Old and new injection marks were observed in his right cubital fossa. Petechiae were observed on the conjunctiva of his right eye, laryngeal mucosa, epicardium and under the capsule of the liver (to a slight or moderate degree). The brain, weighing 1.67 kg, was heavily edematous; the lateral and fourth ventricles were filled with hematomas. Subarachnoid, intracerebral hemorrhages were not observed. Cerebral vascular abnormalities were not evident. There were no remarkable changes in other organs, other than congestion. Gas chromatographic-mass spectrometric analysis of the urine disclosed the presence of methamphetamine and amphetamine. The concentration of methamphetamine within the femoral venous blood and intraventricular hematoma was 0.347 microg/ml and 0.189 microg/g, respectively. Amphetamine was not detected in either sample. Urine contained 3.15 microg/ml methamphetamine and 0.063 microg/ml amphetamine. These results indicate that intraventricular hemorrhage might have occurred shortly after intravenous self-administration of methamphetamine. Cerebral arterial spasm and hypertension resulting from the administration of methamphetamine might have resulted in intraventricular hemorrhage.     

美国与东亚大国的关系--东南亚的视角

本文评述了美国与东亚大国———中国、日本、俄罗斯、印度及东盟的关系,以及这些关系对东亚的影响,并着重分析了中国与东亚大国的关系。作者认为,中美关系肯定是未来东亚地区最重要的战略关系。中国的崛起促使创立东亚地区机制成为必要。多边合作是解决和克服双边低效的最直接的战略,因此,创立东亚共同体的想法具有很重要的意义。     

印尼民主化进程、中国印尼关系及国际形势评析

应暨南大学的邀请,2006年5月27-30日,印尼前国家领导人———印尼人民协商会议(MPR)主席、印尼国民使命党前任总主席、穆罕默迪亚前任总主席、现印尼国民使命党荣誉主席、印尼知名学者阿敏.赖斯教授(Prof.Dr.HM Amien Rais)对暨南大学进行了为期3天的学术访问,并被聘请为暨南大学客座教授。期间,阿敏.赖斯教授做了两场学术报告,分别就印尼民主化进程、中国印尼关系、国际形势等诸多问题发表了看法。参加学术报告会的有暨南大学东南亚研究所暨国际关系学系师生、印尼留学生、广东外语外贸大学印尼语专业师生和广州市、中山市、珠海市的印尼归侨代表等130人,东南亚研究所所长曹云华教授主持了学术报告会。现对其主要观点和看法进行整理,以飨广大     

浅议环境对汉语学习的影响

环境对学习语言非常重要,充分利用社会大环境,创造良好的课堂小环境,发挥学生自然习得的作用,建立课堂教学与自然习得相结合的新教学体系,这是提高教学效果的重要途径。     

上海合作组织五周年宣言

值此上海合作组织(以下简称“本组织”)成立5周年之际,本组织成员国元首——哈萨克斯坦共和国总统纳扎尔巴耶夫、中华人民共和国主席胡锦涛、吉尔吉斯共和国总统巴基耶夫、俄罗斯联邦总统普京、塔吉克斯坦共和国总统拉赫莫诺夫、乌兹别克斯坦共和国总统卡里莫夫在本组织诞生地——上海举行会议,声明如下:     

贫国与富国:基于治理理论的解释

本文通过对荷兰与加纳、新加坡与牙买加、日本与尼日利亚等几组国家进行比较研究,指出国家贫富差别的主要原因在于治理,而非资源。