Inter- and intra-subject variability in ethanol pharmacokinetic parameters: effects of testing interval and dose

Calculation of a blood alcohol concentration (BAC) at the time of an offence by forward or back-extrapolation, using population average values for ethanol pharmacokinetic parameters or a single estimate of individual specific parameters, ignores the possibility of inter- and intra-subject variability. In order to estimate inter- and intra-subject variability in the elimination rate and absorption rate, BAC was measured over time in 12 male volunteers on 4 occasions. Subjects received 0.44 g kg(-1) body weight of ethanol on the first study day, and 0.70 g kg(-1) body weight on subsequent study days 1, 11 and 12 weeks later, to enable comparisons in variability over short and long time periods and when the same or different doses were administered. Evidence of both inter- and intra-subject variability was found, with inter-subject variability substantially smaller than intra-subject variability when the dose varied. Forensically important differences in pharmacokinetic parameters were observed within individuals between occasions. These findings could have an important impact on medico-legal issues related to ethanol pharmacokinetics.     

Why Cryptocurrencies Want Privacy: A Review of Political Motivations and Branding Expressed in “Privacy Coin” Whitepapers

New currencies designed for user anonymity and privacy – widely referred to as “privacy coins” – have forced governments to listen and legislate, but the political motivations of these currencies are not well understood. Following the growing interest of political brands in different contexts, we provide the first systematic review of political motivations expressed in cryptocurrency whitepapers whose explicit goal is “privacy.” Many privacy coins deliberately position themselves as alternative political brands. Although cryptocurrencies are often closely associated with political philosophies that aim to diminish or subvert the power of governments and banks, advocates of privacy occupy much broader ideological ground. We present thematic trends within the privacy coin literature and identify epistemic and ethical tensions present within the communities of people calling for the adoption of entirely private currencies.     

Reforming war's administrative rubble in Lebanon

After 17 years of civil strife in Lebanon, an Office of Minister of State for Administrative Reform (OMSAR) was established in 1993 to plan for short‐term rehabilitation and long‐term institutional development within the public sector. Since external technical assistance to public administration was delivered through OMSAR, its role as a host agency for international aid donors' efforts in reform policy‐making and implementation is critical. The article discusses OMSAR's approach to channelling foreign aid for administrative development in post‐war Lebanon. Lessons from the Lebanese experience in post‐war institutional development may interest countries emerging from conflicts and trying to rebuild administrative infrastructure. Copyright © 2004 John Wiley & Sons, Ltd.     

Justice and organizational punishment: Attitudinal outcomes of disciplinary events

This study utilized a justice framework to investigate punished subordinates' attitudinal reactions to specific disciplinary events. Results suggested that personality variables (negative affectivity and belief in a just world) influenced subordinate perceptions of the disciplinary event. In addition, belief in a just world had a direct effect on satisfaction with the supervisor, intention to leave, and organizational commitment. Contrary to expectations, harshness (a distributive aspect of the event) influenced perceptions of procedural justice and attitudes toward the institution (organizational commitment) and the leader (trust in supervisor), in addition to its influence on perceptions of distributive justice. The influence of procedural aspects of the event on attitudinal outcomes varied by dependent variable. The implications for future research and for management are discussed.     

Developing the relevance potentialities of national security and foreign policy research: Some proposed criteria

While effective foreign and national security policy-making increasingly requires research that is produced outside government, little is known about how such research affects the actions of policy-makers, or why it may or may not be policy-relevant to them. This essay poses a number of criteria which can be used to weigh the policy relevance of applied social science research for national security and foreign policy issues. These criteria can be divided into content and process categories, the former including aspects of time, issue salience, format, and confidence; and the latter incorporating questions related to the origin of research, the strategy which informs it, and the tactics by which it is presented. Hopefully, such criteria can be applied to existing works, serve as guidelines for future research, and perhaps illuminate the general role of social knowledge in policy formulation.The authors wish to express their appreciation for the opportunity to participate in the National Security Education Seminar held at Colorado College, Colorado Springs, Colorado, June 18–July13, 1973, directed by Fred A. Sondermann and conducted under the auspices of the National Security Program, New York University, Frank N. Trager, Director. This paper is a revised version of a report originally prepared for the seminar. The views presented here are those of the authors, and not necessarily of any of the institutions with which they are associated.