Regulation under uncertainty: The coevolution of industry and regulation

As production and design disintegrate and become more collaborative, involving dynamic relations between customers and firms supplying complex subsystems and service, products and production methods become more innovative but also more hazardous. The inadvertent co‐production of latent hazards by independent firms is forcing firms and regulators to address the problem of uncertainty – the inability to anticipate, much less assign a probability to future states of the world – more directly than before. Under uncertainty, neither the regulator nor the regulated firms know what needs to be done. The regulator must induce firms to systematically canvas their practices and identify potential hazards. But recognizing the fallibility of all such efforts, the regulator must further foster the institutionalization of incident or event reporting procedures: systems to register failures in products or production processes that could be precursors to catastrophe; to trace out and correct their root causes; to alert others in similar situations to the potential hazard; and to make certain that countermeasures to ensure the safety of current operations are taken and the design requirements for the next generation of the implicated components or installations are updated accordingly. In this essay we develop these arguments and look closely at changes in the Norwegian offshore oil and gas industry and its regulator, the Petroleum Safety Authority to better understand the coevolution of vertically disintegrated industry and new forms of regulation.     

"In Essence still a British Country": Britain's withdrawal from East of Suez

In the summer of 1967 Harold Wilson's Government announced the withdrawal of British forces from East of Suez. This article examines how Australian politicians and commentators responded to their changing geo-strategic environment and how Britain's withdrawal was seen as a crucial moment in the development of Australian nationhood. It shows that the dismantling of the links with Britain did not allow a dormant Australian national idea to (re)surface. While Australians emphasised the need to think harder about forging a distinctive Australian civic identity as the ties with Britain were finally dismantled, very few could define precisely what that might mean, except that it should somehow be "independent" and "new". The question, at a time when it was apparent that the British connection could have no practical meaning, remained whether being Australians meant something radically different from being Australian Britons. The strong emotional ties with Britain were not easily cut, even at a time when it had become fashionable to argue for a cool and practical relationship between the two countries. Thus, Prime Minister Harold Holt could maintain that, despite all the changes, Australia remained "in essence" British.     

Sudden cardiac death in young adults: environmental risk factors and genetic aspects of premature atherosclerosis

Familial hypercholesterolemia (FH) is a genetic disorder that may lead to premature coronary heart disease (CHD) and sudden cardiac death (SCD). Mutations in the LDLR or APOB genes cause FH. We have screened the LDLR and the ligand-binding region of APOB genes in 52 cases of SCD. Deceased patients were younger than 40 years of age and were suspected of having FH. The LDLR and APOB genes were examined via PCR, high-resolution melting, and DNA sequencing. Therein, it was observed that 7.7% of the screened patients exhibited a rare sequence variant in the LDLR gene, with 5.7% suspected of being pathogenic mutations. Lipid profiles and genetic testing for FH could be considered when autopsy reveals significant atherosclerosis of the coronary arteries in young adults. First-degree family members are advised to seek medical advice and testing to determine their own risks of atherosclerosis to prevent premature CHD and SCD.