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71.
Chang Hua Wong Seok Hwee Koo George Qiongze She Paul Chui Edmund Jon Deoon Lee 《Forensic Science International Supplement Series》2009,192(1-3):53-55
We analyzed the coding regions of the cardiac calcium-handling genes, ryanodine receptor 2 (RyR2) and calsequestrin 2 (CASQ2) for genetic variants in a healthy Chinese population (n = 95) and in a cohort of 28 sudden unexplained death victims. Mutations in RyR2 and CASQ2 have been shown to alter calcium homeostasis during excitation–contraction coupling and predispose individuals to fatal cardiac arrhythmias. The genetic screening was accomplished by denaturing high-performance liquid chromatography and DNA sequencing methods. Genetic analysis revealed the following non-synonymous genetic variations: two reported RyR2 polymorphisms; 5654G>A (G1885E) and 5656G>A (G1886S), two reported CASQ2 polymorphisms; 196A>G (T66A) and 226G>A (V76M) and one novel CASQ2 mutation; 529G>C (E177Q). The functional significance of the novel CASQ2 mutation has not been evaluated and characterized. This study shows that multiple genetic variations of the RyR2 and CASQ2 genes exist in the two study populations. The inter-individual genetic variability may underlie the different susceptibility of individuals to developing ventricular tachycardia. The research results will be valuable for which future work involving clinical and forensic samples can be based upon to distinguish potential disease-associated mutations from common polymorphisms. 相似文献
72.
Jon Rubin 《Feminist Legal Studies》2001,9(1):75-83
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This study employs twenty-three years of federal, state, andinstitutional student-aid data to investigate the effects offederal grants to students on the behavior of higher educationinstitutions. Unlike previous studies, this research differentiatesbetween federal-aid programs according to whether a federalprogram follows "redivision federalism" or "cooperative federalism"concepts. Pell grants, exemplifying the former, appear highlyfungible and inversely related to institutional grants to students,while campus-based federal programs, exemplifying "cooperativefederalism, " appear less fungible and positively associatedwith institutional grants. The results also suggest that grantsto students are more important to higher education opportunitythan indicated by some previous research. 相似文献
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Jon Piccini 《澳大利亚政治与历史杂志》2017,63(1):158-159
From Victims to Suspects: Muslim Women Since 9/11. By Shakira Hussein (Sydney: NewSouth, 2016), 192 pp. AU$24.99 (pb). 相似文献
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Jon Taylor 《北京周报(英文版)》2018,61(29):20-21
正The United States goes it alone down the protectionist road On July 6,U.S.President Donald Trump launched a series of punitive and counterproductive tariffs on $34 billion worth of Chinese goods and products.In response,China applied reciprocal tariffs on$34 billion worth of U.S.goods.These moves come on top of U.S.tariffs already imposed on Chinese steel,aluminum,washing machines and solar panels. 相似文献