谷氨酸受体基因单核苷酸多态性与精神分裂症的关联

谷氨酸是人类神经系统中重要的兴奋性神经递质,通过与受体结合发挥生物学作用.当编码受体的基因异常时,可能导致精神疾病发生.本文通过回顾相关研究,发现诸如GRIN1、GRIN2B、GRM3等受体基因上的rs11146020、366C/G、rs1468412与精神分裂症相关联;同时也存在矛盾的研究结果,表明精神分裂症可能为多因素、多位点、多基因复杂遗传疾病.部分位点如GRIN2B上的366C/G、2664C/T,GRIK2上的rs1408766(C/T)的遗传多态性较好,可能成为法医学个人识别与亲权鉴定的新指标.该领域研究在司法精神病的鉴定工作中可能具有潜在的意义.     

DNA polymorphism detection of Papaver somniferum L using fluorescent amplified fragment length polymorphism

OBJECTIVE: To detect DNA polymorphism of Papaver somniferum L using fluorescent Amplified Fragment Length Polymorphism. METHODS: Genomic DNA was isolated using the AxyPrep DNA Kit, double-digested by two restrictional endonucleases (Eco RI and Mse I) and ligated to oligonucleotide adapters. After Pre-amplification and selective amplification, the DNA fragments were separated by capillary electrophoresis using the CEQ8000 DNA Fragment Analyzer. RESULTS: More than 20 fragments of highly polymorphic products were obtained by 8 pairs of primer from 64 selective amplifying primer pairs. CONCLUSION: The fluorescent AFLP technique can be used to detect the DNA polymorphism of Papaver somniferum.     

Effect of China’s rise on East Asian economic integration

This article discusses the effect of China’s economic rise on East Asian economic integration and concludes that the emergence of China as an increasingly important economic power has made a great contribution to Asian economic integration mainly through four channels: being a main importer and FDI destination country for most Asian countries under the processing export pattern; the renminbi’s more active image in the regional currency cooperation and its potential role as one of the core regional currencies in the future; playing a more important role in the regional political affairs and having an increasing potential to be part of the political core power (together with Japan); the demonstration and stimulative effects made by the motion of the FTA between China and ASEAN.

双循环新发展格局中所蕴含的几对重要关系探析

根据当前国内外经济出现的新变化和新趋势,党的十九届五中全会提出了要加快构建以国内大循环为主体、国内国际双循环相互促进的新发展格局。落实好双循环新发展格局,必须要科学认识其中所蕴含的几对重要关系,这几对重要关系分别是国内市场和国际市场的关系、生产与消费的关系、政府与市场的关系、总供给与总需求的关系以及资本主义和社会主义的关系。能否科学处理这几对重要关系,事关双循环新发展格局的顺利运行。     

消费者购房消费动机及差异研究——以合肥市为例

本研究采用自编的《消费者购房消费动机问卷》在合肥市进行了调查。通过独立样本t检验等统计方法探讨了性别、婚姻状况、年龄、家庭收入、文化程度、居住现状及购房次数对消费者购房消费动机的影响。其中男性、单身和30岁以下的消费者更注重住房的社会象征意义,表现较高的从众倾向,已婚、30岁以上、具有合肥市户口的消费者则更加关注学区房因素;学历较高和收入高的消费者都更为关注经济因素、住房的象征意义,表现较高的从众倾向;有房者更注重经济因素和学区房因素,发生更少的从众行为。     

干扰素压力下传代的猪繁殖与呼吸综合征病毒对ISG56转录的影响

为探究猪干扰素-β(swIFN-β)加速猪繁殖与呼吸综合征病毒(PRRSV)变异是否对病毒致病机制存在影响,将PRRSV GD07在干扰素压力下传代至第70代,同时构建SYBR Green实时荧光定量PCR方法,研究干扰素压力下传代毒株(PRRSV GDβfn)、自然条件下传代毒株(PRRSV GDfn)和原代毒株(PRRSV GDf1)等对干扰素诱导基因56(IFN-stimulated gene-56,ISG-56)转录的影响。结果显示,PRRSV能够抑制由干扰素诱导产生的ISG56的转录,其抑制能力大小依次为PRRSV GDβf20PRRSV GDf20、PRRSV GDβf50PRRSV GDf50、PRRSV GDβf70PRRSV GDf70;不同代次之间PRRSV GDf1PRRSV GDf20/PRRSV GDβf20PRRSV GDf50/PRRSV GDβf50PRRSV GDf70/PRRSV GDβf70。结果说明,构建的荧光定量方法能够检测出不同PRRSV毒株在抑制ISG56转录上的差异;随着在细胞上传代次数的增加,PRRSV GDβfn和PRRSV GDfn对ISG-56转录的抑制能力均逐渐减弱;在同一代次中,PRRSV GDβfn对ISG-56转录的抑制能力要强于PRRSV GDfn。     

探究《物权法》与物权习惯法的融合点

物权交易的规则可以扩大理解为制定法和习惯法。习惯法中的物权公示的形式及变动的规则符合我国物权法的物权法定原则。甘南藏族自治州物权习惯法表明了当代中国物权习惯法的客观存在,应当充分认识这一习惯法的功效,总结其社会价值和对甘南地区经济社会发展的积极意义。     

Can Genetics Predict Response to Complex Behavioral Interventions? Evidence from a Genetic Analysis of the Fast Track Randomized Control Trial

Early interventions are a preferred method for addressing behavioral problems in high‐risk children, but often have only modest effects. Identifying sources of variation in intervention effects can suggest means to improve efficiency. One potential source of such variation is the genome. We conducted a genetic analysis of the Fast Track randomized control trial, a 10‐year‐long intervention to prevent high‐risk kindergarteners from developing adult externalizing problems including substance abuse and antisocial behavior. We tested whether variants of the glucocorticoid receptor gene NR3C1 were associated with differences in response to the Fast Track intervention. We found that in European‐American children, a variant of NR3C1 identified by the single‐nucleotide polymorphism rs10482672 was associated with increased risk for externalizing psychopathology in control group children and decreased risk for externalizing psychopathology in intervention group children. Variation in NR3C1 measured in this study was not associated with differential intervention response in African‐American children. We discuss implications for efforts to prevent externalizing problems in high‐risk children and for public policy in the genomic era.     

习近平国家治理思想的三维审视:认知、价值、实践

自党的十八届三中全会提出"推进国家治理体系和治理能力现代化"以来,习近平在不同的场合对国家治理进行了相关论述,总结习近平的国家治理思想,对于推进国家治理体系和治理能力现代化具有重要意义。     

科学发展观论析

党的新一届领导集体提出的科学发展观,是对中国社会主义现代化规律认识的进一步深化,是指导发展的世界观和方法论的集中体现,是新世纪新阶段推进社会主义经济建设、政治建设、文化建设、社会建设全面发展的根本指针。科学发展观的形成,体现了我们党在社会主义现代化建设指导思想上的与时俱进,具有十分重大的理论创新价值。