Fatal intoxication with 1,4-butanediol: Case report and comprehensive review of the literature

A fatal case of 1,4-butanediol (1,4-BD) oral ingestion is reported here, in which a 51-year-old man was found dead in his bed. According to the police report, the deceased was a known drug user. A glass bottle labeled (and later confirmed to be) “Butandiol 1,4” (1,4-BD) was found in the kitchen. Furthermore, the deceased's friend stated that he consumed 1,4-BD on a regular basis. The autopsy and histological examination of postmortem parenchymatous organ specimens did not revealed a clear cause of death. Chemical-toxicological investigations revealed gammahydroxybutyrat (GHB) in body fluids and tissues in the following quantities: femoral blood 390 mg/L, heart blood 420 mg/L, cerebrospinal fluid 420 mg/L, vitreous humor 640 mg/L, urine 1600 mg/L, and head hair 26.7 ng/mg. In addition, 1,4-BD was qualitatively detected in the head hair, urine, stomach contents, and the bottle. No other substances, including alcohol, were detected at pharmacologically relevant concentrations. 1,4-BD is known as precursor substance that is converted in vivo into GHB. In the synoptic assessment of toxicological findings, the police investigations and having excluded other causes of death, a lethal GHB-intoxication following ingestion of 1,4-BD, can be assumed in this case. Fatal intoxications with 1,4-BD have seldom been reported due to a very rapid conversion to GHB and, among other things, non-specific symptoms after ingestion. This case report aims to give an overview to the published of fatal 1,4-BD-intoxications and to discuss the problems associated with detection of 1,4-BD in (postmortem) specimens.     

Genetic data on eight STRs (D5S818, D7S820, F13B,LPL, TH01, TPOX,VWA31, CSF1PO) from a Colombian population

Allele frequencies for eight short tandem repeats (STRs) (D5S818, D7S820, F13B, LPL, TH01, TPOX, VWA31 and CSF1PO) were estimated from a sample of 155 unrelated individuals living in different departments of the southwest of Colombia, Caquetá, Cauca, Huila, Nari?o, Putumayo and Cauca Valley.     

Y-chromosome STR-haplotype typing in El Salvador

Eight Y-chromosome STRs were investigated in a male population sample from El Salvador. Complete Y-chromosomal STRs haplotypes were obtained in 121 individuals, among which 107 different haplotypes were observed. The two most common haplotypes were shared by approximately 4% of the sample, while 100 haplotypes were unique. The gene diversity was 0.9883 and the discrimination capacity was 0.8926. The combined Y-chromosome STR polymorphisms provide a powerful discrimination tool for routine forensic applications.     

The Normality of Political Administration and State Violence: Casuistry,Law, and Drones

Large unmanned aerial vehicles (i.e., drones) equipped with missiles and bombs or battle-equipped have progressively become the newest wave in “warfare.” We argue that the use of drones for targeted assassinations is merely a new technological tool for state violence that is increasingly becoming a regular exercise of the US power in the construction and reification of the broader social geopolitical order. Further, it is through law, domestic and international, that state violence, wars and the use of drones for targeted assassinations are legitimated and are a normality, and continuation of, the political management of the state. Taken with the core of humanitarian law that legitimates war and state violence, we suggest that the use of drones can be interpreted within the body of legislation, political discourse, and laws that serve to normalize and legitimize their use: no different than such processes that occurred with the technological advances that offered military tanks, aerial bombing, projectile missiles or even nuclear and chemical weapons.     

The showup identification procedure: An exploration of systematic biases

Purpose. Showups are common, yet little research has investigated the biasing factors that may influence showup identifications. We investigated the effects of cross‐race conditions and clothing bias on showup identification decisions. Additionally, we explored identification decisions made in a subsequent lineup dependent on race, clothing, and showup‐target‐presence. Methods. Participants watched a mock crime and were presented with a showup in which suspect race, target‐presence, and the clothing worn by the suspect were varied. Following a delay, participants viewed a target‐present or ‐absent lineup and were asked to make a second identification decision. Results. Presentation of the suspect in the clothing worn by the perpetrator increased choosing rates in both own‐race and other‐race conditions. Despite this, differential patterns of decision response latencies indicated that eyewitnesses may use clothing information differently when making own‐race compared to other‐race identification decisions. No evidence for an own‐race bias in showup identifications was found; however, other‐race lineup identifications were less accurate than own‐race lineup identifications. Further, participants in own‐race and other‐race conditions differed in the extent to which they were affected by multiple identification procedures. Viewing an own‐race innocent suspect in a showup increased subsequent false lineup identifications, while choosing the innocent suspect from the showup was necessary to increase false lineup identifications in other‐race conditions. Conclusions. Different situational factors may affect the identification accuracy of eyewitnesses in own‐race and other‐race conditions for both showup and lineup procedures. Particular caution is advised when showups are clothing‐biased and multiple identification procedures are used.     

Effect of Substrate Interferences from High‐Density Polyethylene on Association of Simulated Ignitable Liquid Residues with the Corresponding Liquid

The effect of substrate interferences from high‐density polyethylene (HDPE) on the ability to associate an ignitable liquid residue with the corresponding liquid standard, using statistical procedures, is demonstrated. Gasoline, kerosene, and lighter fluid, at three different evaporation levels, were spiked onto HDPE and subsequently burned to generate simulated ignitable liquid residues (ILRs). Samples were extracted using a passive headspace procedure and analyzed by gas chromatography–mass spectrometry. The total ion chromatograms were subjected to data pretreatment procedures prior to principal components analysis and Pearson product moment correlation. Using the combination of these statistical procedures, simulated ILRs were successfully associated with the corresponding liquid type, despite the presence of compounds inherent to the HDPE substrate, as well as those resulting from pyrolysis of the substrate.     

Community Responsibility for Preventing Sexual Violence: A Pilot Study with Campus Greeks and Intercollegiate Athletes

Previous research has noted higher incidences of sexual violence on campus among members of campus Greeks and athletes and the need to do prevention programs with them. This article presents the results of an exploratory pilot study of a sexual violence prevention program with members of one fraternity, sorority, men's and women's intercollegiate athletic team. The program, experimentally evaluated and found to be effective with a general sample of undergraduates, was used to determine its efficacy specifically with Greeks and athletes. The model on which the program is based calls for prevention efforts that take a wider community approach rather than simply targeting individuals as potential perpetrators or victims. Results from repeated-measures analysis of variance indicate that the program worked overall. Future directions are discussed.     

Clarifying Consent: Primary Prevention of Sexual Assault on a College Campus

Although more universities are developing policies for students regarding consent for sexual behavior in response to the problem of sexual violence on campus, many students seem either unaware of these policies or what they mean for actual behavior. Policies are only as effective as peoples' understanding and use of them. The current study aimed to evaluate the utility of a prevention education program focused on teaching students about consent. Two hundred and twenty undergraduates, composing a control group, a shorter treatment group, and a longer one, participated in the study. The findings showed the greatest knowledge gain for participants in the longer treatment group that included a discussion of the policy and participation in an activity dealing with its implications. Implications and future research directions are discussed.     

PAKISTAN (REVIEW ARTICLE)

Victoria Schofield reviews two books on Pakistan:- the third, much revised, edition of Owen Bennett Jones’ Pakistan In the Eye of the Storm and Hilary Synnott's Transforming Pakistan, Ways out of Instability. Both books are arranged thematically and are full of useful information. They underline how important it is for outsiders to understand the course of recent events. For even though the problems facing Pakistan can in the end only be resolved by Pakistanis, outsiders undoubtedly have a crucial role to play.