我的光影世界

<正>我生长在江门农村,自幼顽皮,在一次和同学打闹时不慎摔断了左手,没想到医院的一个失误竟然让这只手慢慢枯萎,最终残疾。祸不单行,两年后一个不小心我又摔坏了右手。当时年纪还小,只知道手没人家好看没人家力气大。可有一天,父母的议论让我突然明白了这件事对我有多重要。我害怕了,就拼命地锻炼。左手已经彻底废了,我就练右手,每天三次单手吊环,伤处那种撕心裂肺的疼痛只有经历过的人才知     

Reliability Study on Quantitative Detection of Extensor Digitorum Brevis Strength with Needle Electromyography and Nerve Conduction

Objective To study the objectivity and reliability of needle electromyography and nerve con- duction for detection of musculus extensor digitorum brevis strength, which may provide a basis for es- tablishing a quantitative detection of muscle strength in forensic clinical study. Methods Forty-four healthy people were enrolled as the subjects, and during toe dorsiflexion, the following items including needle electromyography indexes, motor unit potential （MUP） amplitude, MUP count, recruitment reaction type, and nerve conduction detection indexes, compound muscle action potential （CMAP） amplitude, CMAP latent period and motor nerve conduction velocity （MNCV）, were simultaneously detected under the co- operation and disguise condition. Results Under the cooperation condition, regardless of the same opera- tor or different operators, there were good test-retest reliabilities in MUP amplitude, CMAP amplitude, CMAP latent period and MNCV, while there were normal test-retest reliabilities in MUP count and re- cruitment reaction type and the repeatability of the same operator was slightly better than the repeatabili- ty between different operators. Under the disguise condition, test-retest reliabilities of MUP amplitude, CMAP amplitude, CMAP latent period and M-NCV were relatively high, while test-retest reliabilities of MUP count and recruitment reaction type were relatively low. Conclusion There are good test-retest reli- abilities in MUP amplitude, CMAP amplitude, CMAP latent period and M-NCV, which can be conducive to comparison between different operators and results at various times; MUP count and recruitment reac- tion type, which can be easily affected by subjectivity of operators and examinees, can be used to dif- ferentiate whether an examinee disguises or not. The indexes used to objectively judge muscle strength remain to be further investigated.     

鱼肌肉中氟苯尼考和氟苯尼考胺残留的高效液相色谱检测

建立了同时检测鱼肌肉组织中氟苯尼考和氟苯尼考胺残留的高效液相色谱检测法。以水和丙酮为提取溶液,Oasis MCX固相萃取柱为净化柱,采用Inertsil ODS—3(5μm,250 mm×4.6 mm i.d.)反相色谱柱,以A液(0.02 mol/L庚烷磺酸-钠0.025 mol/L磷酸钠溶液,二者体积比68∶32,pH3.85)与B液(含1 mL/L三乙胺的甲醇溶液)为流动相,梯度洗脱,紫外检测器225 nm处检测。结果显示,在10~1 000μg/kg浓度范围内,线性关系良好;加标回收率为75.9%~82.8%,日内变异系数为2.1%~5.8%,日间变异系数为4.7%~7.7%;氟苯尼考胺和氟苯尼考的检测限分别为5μg/kg和10μg/kg,定量限分别为10μg/kg和20μg/kg。结果表明,所建立的检测方法具有灵敏、准确、简便、快速的特点,适于同时检测鱼肌肉中氟苯尼考和氟苯尼考胺的残留。     

基于肿瘤微环境探讨癌性疼痛络病病机的生物学基础

基于络病理论,癌性疼痛的核心病机是络虚邪瘀,具体病机变化分为络气郁滞、络脉瘀阻、痰湿阻络、热毒滞络、络虚不荣。在癌性疼痛的发病机制中,肿瘤微环境发挥了重要作用。络脉及其中气血津液的具体变化引起癌性疼痛的过程与肿瘤微环境及其中发生物质转换、信息传递并产生疼痛的过程相类似。络气郁滞与神经内分泌免疫调节、络脉瘀阻与低氧微环境、痰湿阻络与酸性微环境、热毒滞络与炎症微环境、络虚不荣与免疫微环境分别具有相关性,肿瘤微环境可能是癌性疼痛络病病机的生物学基础。     

肌皮神经损伤后屈肘肌力与针极肌电图指标的相关性

目的 研究肌皮神经损伤者的屈肘肌力变化及其与针极肌电图指标的相关性。方法 收集单侧臂丛神经损伤（累及肌皮神经）致屈肘肌力降低案例30例，根据Lovett肌力分级标准进行徒手肌力评定，并将30例受试者分为A组（伤侧徒手肌力1级和2级，16例）和B组（伤侧徒手肌力3级和4级，14例）。对所有受试者的伤侧和健侧肱二头肌行针极肌电图检测。记录肱二头肌复合肌肉动作电位（compoundmuscle actionpotential,CMAP）的潜伏期和波幅。受试者进行最大随意收缩时，记录募集反应类型以及募集电位的平均转折数和平均波幅，并采用microFET2便携式肌力测试仪检测屈肘定量肌力。计算残存屈肘肌力百分比（伤侧与健侧定量肌力的比值）。比较各针极肌电图指标、定量肌力、残存屈肘肌力百分比在两组之间和组内伤侧与健侧之间的差异。分别分析屈肘徒手肌力分级、定量肌力与针极肌电图指标的相关性。结果 肌皮神经损伤后B组的伤侧残存屈肘肌力百分比为23.43%,A组的伤侧残存屈肘肌力百分比为4.13%。伤侧徒手肌力分级与募集反应类型相关，相关系数为0.886(P<0.05)。伤侧定量肌力与CMAP潜伏期...     

中药经皮给药治疗疼痛临床研究

目的 观察中药经皮给药治疗疼痛的临床疗效。方法 共选择疼痛患者1 621例，其中闭合性胸肋部软组织损伤1 080例，腰背肌筋膜炎181例，肩关节周围炎360例，将每种疾病患者随机分为治疗组和观察组，治疗组用祛风散寒、活血通络、消炎止痛中药的乙醇提取液喷洒患处；对照组给予常规治疗。所有患者治疗前后进行疼痛评分，比较两组疼痛缓解时间和临床疗效。结果 对于3种疾病，治疗组疼痛缓解时间和疼痛评分显著低于对照组（P<0.01），总有效率显著高于对照组（P<0.01）。结论 具有祛风散寒、活血通络、消炎止痛的中药经皮给药治疗疼痛见效快，疗程短，治愈率高。