大鼠早期心肌缺血心肌肌钙蛋白T脱失的组化研究

目的研究早期心肌缺血大鼠模型上心肌肌钙蛋白T的脱失情况。方法应用免疫组化LSAB法显色观察。结果缺血15分钟,大鼠心肌肌钙蛋白T即有明显脱失,随缺血时间的延长,脱失面积呈扩大趋势。计算机图像分析显示缺血大鼠心肌肌钙蛋白T的脱失面积与正常大鼠心肌之间存在显著性差异。结论心肌肌钙蛋白T是诊断早期心肌缺血的较为敏感的指标之一。     

A large-scale study of the relationship between blood and breath alcohol concentrations in New Zealand drinking drivers

Blood alcohol concentrations (BAC) and corresponding breath alcohol concentrations (BrAC) were determined for 21,582 drivers apprehended by New Zealand police. BAC was measured using headspace gas chromatography, and BrAC was determined with Intoxilyzer 5000 or Seres Ethylometre infrared analysers. The delay (DEL) between breath testing and blood sampling ranged from 0.03 to 5.4 h. BAC/BrAC ratios were calculated before and after BAC values were corrected for DEL using 19 mg/dL/h as an estimate of the blood alcohol clearance rate. Calculations were performed for single and duplicate breath samples obtained using the Intoxilyzer (groups I-1 and I-2) and Seres devices (groups S-1 and S-2). Before correction for DEL, BAC/BrAC ratios for groups I-1, I-2, S-1, and S-2 were (mean+/-SD) 2320+/-260, 2180+/-242, 2330+/-276, and 2250+/-259, respectively. After BAC values were adjusted for DEL, BAC/BrAC ratios for these groups were (mean+/-SD) 2510+/-256, 2370+/-240, 2520+/-280, and 2440+/-260, respectively. Our results indicate that in New Zealand the mean BAC/BrAC ratio is 19-26% higher than the ratio of the respective legal limits (2000).     

实践“三个代表”与加速科技进步

在今天这样的新形势下,实践“三个代表”,需要不断地加速科技进步。而加速科技进步的关键是加强科技发展能力的建设。     

布氏锥虫伊氏亚种体外药敏试验

应用布氏锥虫伊氏亚种(Trypanosoma brucei evansi,T.b.e)体外药敏试验系统检查了国内6个T.b.e虫株和国外布氏锥虫指名亚种(T.b.b)对苏拉灭(Suramin)、贝尼尔(Berenil)、安锥赛(Antrycide)、咪唑苯脲(Imidocard)和硫胂聚氰胺(Cymelarsan)等5种抗锥虫药的敏感性。结果表明,该系统能准确测定不同虫株对各种药物的敏感性,与小鼠治疗试验结果基本相符,发现了国内抗贝尼尔和苏拉灭的T.b.e虫株。     

Globalization of technology-based growth: the policy imperative

The United States became the dominant technology-based economy after World War II and held that position for decades by accumulating a huge base of superior technical, physical, organizational, and marketing assets. However, the world is witnessing the rapid globalization of technology-based competition, which is the result of major commitments by many nations to investment in technology and its effective utilization. The changing dynamics of such competition requires revisions to the centuries’ old law of comparative advantage and the Schumpeterian process of creative destruction. However, U.S. technology-based growth policies have at best stood still for most of this period. The R&D intensity of the U.S. economy is below its peak in the 1960s and its vaunted “high-tech sector” is too small and increasingly challenged to carry the remaining sectors, as was the case before globalization began in earnest. A major reason for inadequate adaptation is the “installed base effect,” which results from the accumulation of the above types of economic assets and in turn creates both complacency and resistance to the need for adaptation. Weak recoveries from the most recent recessions and the sluggish growth in real incomes are major indicators of structural problems that are not being addressed. Catch-up will require adoption of more comprehensive growth policies, implemented with considerably more resources and based on substantive policy analysis capabilities.

中国北方汉族群体CCK-45C/T基因座遗传多态性

胆囊收缩素(cholecystokinin,CCK)基因位于3q12.3,由3个外显子和2个内含子组成,长约7kb[1]。在CCK基因启动子部位有两个多态性SNP基因座,分别是196G/A和45C/T[2]。目前国内尚无有关45C/T多态性基因座的相关数据报道,本文应用荧光标记的TaqMan探针杂交及荧光定量PCR仪进行检测的     

如何真正把加速科技进步摆在经济社会发展的突出位置

找准影响我国科技进步的主要因素,并采取正确、有力措施,才能真正将加速科技进步放在经济社会发展的突出位置。     

锌与维生素A对隐孢子虫感染小鼠免疫功能的影响

为探讨锌和维生素A对隐孢子虫感染小鼠免疫功能的影响,将75只清洁级昆明小鼠随机分成5组,各组均饲喂基础日粮。其中Ⅰ组和Ⅴ组不添加锌和维生素A,Ⅱ组以饮水方式添加锌(38.5μmol/mL),Ⅲ组以灌喂的方法添加维生素 A(400 IU/只),Ⅳ组添加锌和维生素 A,Ⅰ、Ⅱ、Ⅲ、Ⅳ组均在试验开始时灌喂小型隐孢子虫卵囊( 2.56×106/mL),Ⅴ组作为不接种对照。试验结果,Ⅱ、Ⅲ、Ⅳ组小鼠的粪便排卵量和排卵持续时间分别显著低于Ⅰ组(P<0.05);在试验的第 2 周和试验结束时,Ⅱ、Ⅲ、Ⅳ组小鼠血液中CD4、CD8细胞百分率以及CD4/CD8比值均极显著高于Ⅰ组(P<0.01)。表明,锌和维生素A均能够增强小鼠的细胞免疫功能,提高机体抗隐孢子虫感染的能力。     

T.H. Marshall and his critics: reappraising ‘social citizenship’ in the twenty-first century

T.H. Marshall's concept of ‘social citizenship’, developed in the 1949 lecture ‘Citizenship and Social Policy’, remains a vital study of welfare in developed nations. However, Marshall's social citizenship has come under attack as undermining civil liberties, or falling short of offering real equality to marginalised groups. This article returns to Marshall's lecture to show that he was in fact aware of such problems, but nonetheless held the provision of social rights to be a valuable normative project. Furthermore, this article argues that a new social citizenship, incorporating collective rights claims, could present a strong challenge to neoliberalism in contemporary welfare debates.