反相高效液相色谱法同时测定人血清中氯丙嗪与氯扎平的浓度

作者建立了同时测定人血清中氯丙嗪与氯扎平浓度的反相高效液相色谱(RP—HPLC)法。以利眠宁为内标,用环己烷—乙醚(1:1)混合溶剂提取血清中氯丙嗪和氯扎平。高浓度中毒者血清(>1ug/ml)则用乙腈沉淀后直接进行色谱测定。血清中氯丙嗪、氯扎平的方法回收率乎均各为98.5±4.0(SD)%,CV4.2%;99.9±4.1(SD)%,CV4.1%。两药在血清中的最低检测浓度为10ng/ml。本法应用于临床氯丙嗪、氯扎平合用药物的血浓度监测及司法中毒案例的分析,结果满意。     

《道路交通事故受伤人员伤残评定》中精神伤残程度司法鉴定相关问题探讨

在法医精神病学鉴定实践中,精神伤残的评定越来越多。现行《道路交通事故受伤人员伤残评定》标准中关于精神伤残评定的相关条款过于笼统,可操作性差,常因认识不一致而产生歧义。本文结合典型案例主要从三个方面对精神伤残司法鉴定中常见问题进行探讨:(1)在评定智力缺损程度时,应结合伤前智商进行评定;(2)精神伤残评定的时间应在医疗终结后一年;(3)精神伤残评定中应引入量表进行客观评价。     

汽车碰撞中乘员损伤成因分析与计算机仿真研究

目的运用计算机仿真技术模拟汽车碰撞过程,为法医学鉴定及交通事故处理提供参考依据。方法通过对汽车碰撞中乘员损伤成因分析及车辆痕迹检验,建立有效的人体、车辆仿真模型,利用动量冲量法与多刚体动力学结合仿真求解乘员运动模式,客观再现乘员交通伤特点。结果计算机仿真汽车碰撞过程中,人体模型上碰撞部位的分布符合法医学检验所得结果。结论计算机仿真求解乘员交通伤的方法在法医学鉴定和事故责任认定中具有参考价值。     

Relationships between concentrations of cocaine and its hydrolysates in peripheral blood, heart blood, vitreous humor and urine

Cocaine is known to degrade in vivo and in vitro by several hydrolytic mechanisms. A previous study found that the initial amount of cocaine added to plasma could be accounted for by summing the molar concentrations of cocaine's hydrolysis products and the cocaine remaining after hydrolysis. The present study was undertaken to investigate whether or not relationships might exist between such molar concentration sums for different postmortem bodily fluids. Determinations of cocaine, benzoylecgonine, ecgonine methyl ester, and ecgonine were performed using liquid chromatography/mass spectrometry (LC/MS/MS) with heart blood, femoral blood, vitreous humor (VH), and urine (UR). The results demonstrate a strong correlation between blood and VH concentrations (correlation coefficients of 0.88-0.94), weak correlation between the UR and blood concentrations (correlation coefficients of 0.61-0.64), and weak correlation between UR and VH concentrations (correlation coefficient of 0.59). The results demonstrate that ecgonine is a significant hydrolysate with concentrations on the same order of magnitude as benzoylecgonine. The results are consistent with rapid distribution of the parent drug and its hydrolysates in the blood and VH. The strong correlation between the blood and VH demonstrates that VH is an important medium for toxicology testing when attempting to make a determination of cocaine intoxication.     

论西部地区的禁毒情报协作——西部地区毒品犯罪对全国禁毒工作影响研究之二

毒品犯罪的特殊性决定了情报在打击毒品犯罪中的重要性,而毒品犯罪的跨区域性特点决定了加强情报合作和协作的重要性,西部地区在禁毒斗争中不仅要加强国际禁毒情报交流,也要加强各省市区之间的禁毒情报协作.这种协作的途径主要是通过推进公安情报体制的改革、建立西部地区禁毒协作机制、加强"金盾工程"建设、利用公安部驻滇禁毒联络办公室等来进行,协作的内容主要有战略性情报的交流、禁毒基础信息的共享、毒品专案侦查的情报协作等.     

Prevention science,drug abuse prevention,and Life Skills Training: Comments on the state of the science

There has been tremendous growth in the field of prevention science over the past two decades. The defining features of contemporary prevention science are high quality empirical research using rigorous and well-established scientific methods, careful hyphothesis testing, and the systematic accumulation of knowledge. One area where substantial progress has been made is in our understanding of the etiology and prevention of tobacoo, alcohol, and illicit drug abuse. In this paper, we review the growth in prevention as a scientific enterprise, discuss advances in drug abuse prevention research, and review the effectiveness of one approach to the problem of adolescent drug abuse, the Life Skills Traning (LST) program, and the methodological strengths of the LST evaluation research. In addition, we provide a response to criticism regarding two types of data analysis in evaluation research, and show that these analyses can help address a number of important research questions with implications for theory and practice. First, the analysis of high fidelity subsamples can address research questions about the importance of program implementation fidelity; and second, composite measures of concurrent tobacco, alcohol, and marijuana use (i.e., polydrug use) are useful in testing research questions about program effects on more serious levels of drug involvement. With an increasing number of ramdomized controlled trials underway, the field of prevention science is contributing to a new generation of evidence-based approaches and policies that, if widely utilized, offer the potential of reducing the mortality and morbidity associated with a number of major health and social problems.     

The Relationship Between Adolescent Physical Abuse and Criminal Offending: Support for an Enduring and Generalized Cycle of Violence

Prospective investigations have demonstrated support for the cycle of violence theory. However, few studies have examined whether or not abuse occurring during adolescence increases the prevalence and frequency of criminal involvement, or explored the long-term consequences of such victimization. In addition, there has been little investigation of whether or not the effects of abuse vary depending on characteristics of the victim, such as sex, race/ethnicity, age, family structure or income. Using data from the National Youth Survey, this study demonstrates that adolescent physical abuse has immediate and enduring effects on the prevalence and frequency of a variety of self-reported offenses, including violent and non-violent crimes, drug use and intimate partner violence. Furthermore, the study reveals that while victimization increases the prevalence of offending for victims of varying backgrounds, the frequency of offending is moderated by family income, area of residence, and family structure. Implications for prevention are discussed.     

轿车与自行车碰撞事故仿真研究及骑车者致伤特点分析

目的研究计算机仿真技术重建自行车骑行状态下交通事故发生过程,并探讨此技术在分析真实事故中骑车者人体致伤方式、特点及损伤程度上的可行性。方法通过对事故人、车痕迹鉴定和模型建立,构建相关碰撞环境并利用高性能计算机及PC-Crash软件对事故进行再现研究。结果计算机仿真技术建立的人、车模型在模拟碰撞过程中,骑车者发生的运动过程、损伤分布及损伤动力学响应结果与法医学尸表检验人体损伤部位、程度基本吻合。结论利用计算机仿真技术重建自行车骑行状态下的事故碰撞过程、分析骑车者致伤方式及提供损伤部位动力学响应参数等,对于交通伤法医学鉴定及深化交通伤机制研究具有参考价值。     

骑跨伤在机动车碰撞自行车事故中的特征及生物力学分析

目的以真实案例为基础,研究自行车与机动车碰撞交通事故中,不同机动车型、交通方式等因子造成自行车骑车人下肢内侧骑跨伤的特征,分析其生物力学机制。方法选取上海地区发生的自行车与机动车碰撞交通事故案例140例,全面收集现场、自行车、机动车、人体、交通方向等信息,运用回顾性研究方法分析,同时,选取其中典型案例,通过计算机仿真技术模拟事故发生过程,提取人体各受伤部位的动力学响应数值,如加速度、力和力矩等,与案例研究结果对比。结果全部事故中出现骑跨伤与无骑跨伤案例频数相等;侧面撞击与前后方向撞击骑跨伤的发生情况无显著性差别;大型车辆撞击事故中出现骑跨伤频率较低;骑跨伤的发生频率随车速加大而增高;就骑跨伤的分布来说,撞击侧下肢骑跨伤位置低(链条、脚蹬管等损伤),而对侧骑跨伤位置高(鞍座损伤),在小型车辆撞击时该特点更明显。结论分析自行车骑车人的骑跨伤特征和生物力学机制有望对道路交通行为方式鉴定提供新依据。     

比例原则在道路交通管理执法中的运用

道路交通管理的行政权属于警察权的一部分,公安机关行使该权力时存在着很大的自由裁量性,同时也存在很多不完善之处.引进比例原则,对交通管理措施的适用加以合理限制,有利于更好地保障行政相对人的合法权益,也有助于合理发挥管理的效能.