Undiagnosed, untreated acute promyelocytic leukemia presenting as a suspicious sudden death

Acute promyelocytic leukemia (APL) is a subtype of acute myelogenous leukemia frequently associated with clotting abnormalities and severe hemorrhagic diathesis. The disease is associated with a high incidence of early fatal hemorrhage. We report the sudden death of a 40-year-old male without significant medical history in which foul play had been initially suspected. A thorough postmortem investigation performed on the decedent lead to the diagnosis of APL. Cause of death was a cerebellar hematoma. Underlying APL should be considered in the differential diagnosis when unexplained bleeding is encountered in a decedent. This case emphasizes the value of routinely collecting bone marrow during an autopsy to enable accurate testing and diagnosis.     

Peace in the Middle East

正Foreign minister’s trip highlights China’s increasing involvement in the region Chinese Foreign Minister Wang Yi took a tour of the Middle East and North Africa from December 17-26,2013,consisting of stops in Palestine,Israel,     

Moderated Commitment: Members’ Decisions Not to Give to Professional Associations

Abstract

Workers pay membership dues to professional associations, which mark their identification with a particular field. Professional associations invite additional voluntary contributions for new or expanded programs, but most members do not make these additional gifts. We advance and test a conceptual model of the forces that might interrupt an otherwise committed or engaged member’s decision to make such a voluntary contribution. We conclude that giving decisions can be displaced by member beliefs that their dues and fees are sufficient or that their disposable income is committed to other obligations. We also conclude that giving decisions intersect with weak association strategy, such as a failure to solicit gifts in ways that are informative or useful to prospective donors.     

Changing contexts: A quasi-experiment examining adolescent delinquency and the transition to high school

In a quasi-experiment, we examine whether changing schools during the transition from 8th to 9th grade influences adolescent delinquency, using a sample of more than 14,000 students in 26 public school districts (PROSPER study). The dataset follows students for eight waves from 6th through 12th grade and facilitates a unique, direct comparison of students who change schools with those who remain in the same school during this period. Results show that students who transition between schools report significantly less delinquency after the shift than those who do not, and that this difference persists through 10th grade. This decline is most pronounced when adolescents from multiple middle schools move to a single high school (i.e., multifeeder transitions). Students who transition between schools have fewer delinquent friends and participate in less unstructured socializing following the change in school environment, which partially mediates their reduced delinquency. Results provide some support for theories of differential association and routine activities. Our findings highlight the role of a crucial, yet understudied, life transition in shaping adolescent delinquency. The results from this quasi-experiment underscore the potential of alterations in social context to significantly dampen juvenile delinquency throughout high school.     

大鼠急性肾缺血再灌注损伤早期的基因表达

目的研究急性肾缺血再灌注损伤早期的差异基因表达,探索其潜在的分子机制。方法通过单纯夹闭大鼠肾动脉制备肾缺血再灌注模型,进行基因表达芯片检测和生物信息学分析,筛选急性肾损伤早期的差异基因表达及其所涉及的细胞活动和信号通路。同时,通过构建差异表达基因的生物网络来寻找与急性肾损伤关系密切的分子,并进行荧光定量PCR验证。结果在检测出的151个差异表达基因中,132个基因显著上调,19个基因显著下调,GO与KEGG通路富集分析结果显示主要与细胞增殖、细胞因子介导的信号通路和免疫反应等有关。荧光定量PCR结果显示,与对照组相比,挑选出的3个与急性肾损伤高度相关的基因(ANXA1、PHLDA1、KLF6)在疾病早期具有显著的表达差异,上升倍数与芯片检测出的倍数基本一致。结论本研究揭示了急性肾损伤早期的差异基因表达特征以及所涉及的生物学过程和信号通路,其中ANXA1、PHLDA1、KLF6可能在急性肾损伤的发病机制中起到一定作用。     

结核分枝杆菌与牛分枝杆菌PCR快速鉴别检测方法的建立

根据结核分枝杆菌与牛分枝杆菌基因组的比对分析结果,针对结核分枝杆菌与牛分枝杆菌153bp、RD10和TbD1的3处差异缺失区域设计引物,分别建立了结核分枝杆菌与牛分枝杆菌PCR快速鉴别检测方法.应用建立的3种方法分别对84株结核分枝杆菌、3株牛分枝杆菌、51株非结核分枝杆菌及9种其他常见菌株进行了检测.结果显示,用针对153 bp缺失片段建立的PCR方法分别在结核分枝杆菌及牛分枝杆菌中扩增出645 bp及492 bp的目的条带;用针对RD10、TbD1建立的PCR方法分别在结核分枝杆菌及牛分枝杆菌中扩增出478 bp及361 bp的目的条带、358 bp及524 bp的目的条带.这3种PCR检测方法的准确率和特异性均为100%.敏感性试验结果显示,这些检测方法对结核分枝杆菌和牛分枝杆菌基因组DNA的检测极限均为10 pg.表明,此方法可用于牛源或人源结核分枝杆菌及牛分枝杆菌的快速鉴别检测.     

差示扫描量热法检验合成纤维

目的研究不同种类合成纤维以及不同厂家生产的同种类合成纤维的鉴别方法。方法应用功率补偿型差示扫描量热仪测定涤纶、腈纶、锦纶、丙纶、氨纶、氯纶等6种常见合成纤维和10个厂家生产的涤纶纤维的DSC曲线,并对热学参数进行计算和分析。结果涤纶、腈纶、锦纶、丙纶、氨纶、氯纶的DSC曲线明显不同,10个厂家生产的涤纶纤维的DSC曲线虽然非常相近,但对其熔融温度Tm、熔融峰顶温度Tmp、熔融焓变ΔHm、结晶温度Tc、结晶峰顶温度Tcp和结晶焓变ΔHc等热学参数的计算结果显示,10个涤纶纤维的参数并不完全相同。结论差示扫描量热法不但能对不同种类的合成纤维进行鉴别,也可区分不同厂家生产的同种类纤维,从而为案件侦破提供更为准确的方向、线索和证据。     

犯罪学问题清单（一）——有关犯罪学批判的思考

对新中国犯罪学研究中存在争议的、理论的和学术的问题做出简要的梳理是十分必要的。这里仅提出”犯罪学的批判性”和”价值涉入”两个问题并加以讨论。前一个问题作为犯罪学的特质也成为”犯罪学批判”专栏的点题之笔。批判性的缺失与否直接关系到犯罪学能否发挥其正常的学术功能。后一个问题也是犯罪学这种涉及社会黑暗面的学科难以回避的一个问题。价值涉入在中国特殊的文化环境中具有特殊的表现形式,值得认真加以辨析。     

城中村犯罪的形成机制——以深圳T村为例

城中村的犯罪基本上是以侵财为目的的经济型犯罪,尤其是入室盗窃,犯罪者主要为外来务工者。城中村的社区结构特征使得整个社区具有较低的集体效能,出现了社会解组。生活中的＂紧张＂使得外来务工者具备了犯罪动机,老乡网络和城中村越轨网络为犯罪者提供了两种训练渠道,城中村租住者本身的日常活动为犯罪的发生提供了适当的犯罪目标。