Acidic and neutral drugs screen in blood with quantitation using microbore high-performance liquid chromatography–diode array detection and capillary gas chromatography–flame ionization detection

Blood previously acidified with aqueous saturated ammonium chloride solution was extracted with ethyl acetate. The dried extract was subjected to acetonitrile–hexane partition. The acetonitrile portion was analysed for the presence of acidic and neutral drugs by HPLC–DAD (200 mm×2.1 mm I.D. microbore ODS-Hypersil column) and GC–FID (25 m narrow-bore×0.25 mm I.D. HP-5 column with 0.33 μm film thickness). The protocol was found to be suitable for both clinical toxicology (including emergency toxicology) and postmortem toxicology. At least 66 drugs of interest were unequivocally identified by RRTs (HPLC) and UV spectra (DAD) match while another 12 were unequivocally identified by double RRTs match (HPLC and GC). Quantitation was facilitated by incorporating calibration blood standards in each assay batch. The five drugs most commonly encountered in clinical blood specimens (1150 cases) were: paracetamol (47.4% of the cases); chlormezanone (6.6%), theophylline (1.74%), naproxen (1.65%) and mefenamic acid (1.56%). The following drugs were detected in toxicologically significant quantities in postmortem blood specimens (245 cases): phenobarbitone (1.22% of the cases), naproxen (0.82%), chlormezanone (0.82%), theophylline (0.82%), carbamazepine (0.41%) and paracetamol (0.41%).     

关于天津市地方禁毒立法的探索

二十世纪八十年代后,毒品在中国又开始死灰复燃。针对日益严重的毒品违法犯罪,国家制定了一系列法律法规,在禁毒斗争中发挥了巨大作用。但是,由于毒品问题的特殊性和我国国情,仅全国统一禁毒立法还不够,尚需地方立法的细化和补充。本文根据对天津毒品问题的分析和对其他省、市、自治区已有地方禁毒立法的研究比较,指出了制定天津地方禁毒立法的必要性,提出了天津禁毒条例的体系设想,力求为天津的禁毒立法提供某些启示和借鉴,推动我市地方禁毒立法进程。     

确定毒品种类需检测的毒品簇

确定嫌疑人是否吸毒及吸食毒品的种类是打击毒品违法犯罪必不可少的程序。毒品检验是打击毒品犯罪的一个有力工具。可用于毒品检验的方法很多,检测的物质也不尽相同。本文着重介绍用酶联放大免疫分析法所能检测的毒品簇及具体检测物质。     

运输毒品罪主观要件研究

当前,关于运输毒品罪的认定,有许多问题存在争议,特别是主观要件方面,如关于明知的认定,是否包括间接故意,主观动机和目的是不是必备要件,共同犯罪故意的认定,对象认识错误的认定和处罚等。因而有必要对其进行分析研究,以期对铁路公安部门打击运输毒品犯罪有点滴之借鉴。     

新精神活性物质检验鉴定面临的挑战和对策

新精神活性物质更新快,种类繁多,缺乏国际条约的监管,列入联合国管控目录困难,加之一些国家和国际社会对大麻等毒品管控降低,给我国在新精神活性物质类毒品的监管带来困难.具有成瘾性和社会危害性的新精神活性物质才能成为列管对象,毒物分析技术人员在列管程序中扮演极为重要的角色.我国对新精神活性物质的监管法规规定了相关列管程序,毒...     

易制毒化学品犯罪及其惩治对策

目前 ,我国易制毒化学品种类较多 ,管理难度大 ,管理漏洞多 ,易制毒化学品犯罪日趋严重。易制毒化学品犯罪的主要特点是涉及数量大 ,品种多 ,主体复杂 ,隐蔽性强。严厉惩治易制毒化学品犯罪 ,必须提高认识 ,加强领导 ,堵住漏洞 ,严格对缉毒人员的培训 ,提高查缉能力 ,同时要完善相关的法律、法规。     

论加强海关缉毒国际合作

全球性的毒品泛滥愈演愈烈,对人类的生存和社会的发展构成了严重的威胁。尽管各国海关国际缉毒执法合作已取得了很大的成绩,但其中也存在不少问题。面对世界性的毒品危机,必须采取全球性禁毒战略,加强各国政府,尤其是加强海关之间的禁缉毒合作。     

Toxicology and Circumstances of Completed Suicide by Means Other than Overdose*

Abstract: To determine the prevalence and circumstances of psychoactive substances amongst nonoverdose completed suicide, 1436 consecutive cases autopsied at the NSW Department of Forensic Medicine over the period 1/1/1997–12/31/2006 were analyzed. Substances were detected in 67.2% of cases, and illicit drugs in 20.1%. Alcohol was present in 40.6% of cases. Males were more likely to be positive for alcohol, cannabis, and psychostimulants, and females for pharmaceuticals. Illicits were associated with younger age. Alcohol was most prominent amongst toxicity cases, as were opioids, psychostimulants amongst gunshot cases, and pharmaceuticals amongst drownings. Cases in which drug and alcohol histories were noted were more likely to have a substance detected. Alcohol was more common where a suicide note was left and where relationship problems were involved. Pharmaceuticals were more common where a previous attempt was noted. Licit and illicit substances are strongly associated with suicide, even when the method does not involve drug overdose.     

Fourth Amendment update: the Supreme Court and strip searches: Safford Unified School District No. 1 v Redding

In light of the dramatic increase in the presence of weapons, violence, drugs, and other contraband in schools, school officials in the United States and England face significant challenges as they seek to maintain safe and orderly learning environments. Almost twenty five years after the United States Supreme Court's 1985 ruling in New Jersey v. T.L.O. allowed educational officials to search student lockers and property in order to keep schools safe, the Justices addressed the more delicate matter of strip searches for contraband such as drugs. In Safford Unified School District No. 1 v. Redding (Redding), the Court invalidated the strip search of a student for drugs but left the door open for the possibility of allowing searches for weapons under some circumstances. In light of remaining unanswered questions after Redding, this article reviews the background on the Fourth Amendment, earlier cases on student searches in American public schools, Redding in detail, and reflects on unanswered questions in its wake in the hope of shedding light on the propriety of strip searches of students.     

毒品犯罪若干问题新解——以刑法第347条为分析对象

在直接故意犯罪的语境下，以刑法第347条所规定行为到底有没有行为目的，目的是什么为切入点展开论证。刑法第347条规定的走私、贩卖、运输、制造毒品的行为具体是指制造毒品的行为，以贩卖为目的走私、运输，贩卖毒品的行为，以贩卖毒品为目的的持有毒品的行为；区别刑法第348条与第349条的关键在于行为目的确认，对运输毒品行为的定罪方面应具体问题具体分析，不宜一刀切。在运输毒品犯罪中如不能确实认定共同犯罪人的地位时，可以采用部分行为共同责任的原理进行处理。当一行为同时可以被“法条竞合”的各该法条进行事实上的“想象竞合”评价时，有必要在解释时考虑行为目的，以便对行为进行恰当地区分。