致命室性快速心律失常心室肌能量的代谢改变与氧化损伤

目的探讨致命室性快速型心律失常(LVTA)能量代谢相关变化及氧化损伤。方法建立以乌头碱(ACO)注射和冠脉结扎(CAL)心肌缺血诱导的LVTA-心脏性猝死(SCD)SD大鼠模型,以过度麻醉(PI)及冠脉结扎心衰致死(CAL-B)为各自对照,检测心室肌线粒体膜电位(MMP)、活性氧(ROS)、丙二醛(MDA)、磷酸肌酸(PCr)及血清肌钙蛋白I(cTnI)含量,并进行比较。结果成功制备ACO-LVTA及CAL-LVTA大鼠14只及6只。与各自的同行对照比较,ACO-LVTA组及CAL-LVTA组心室肌的ROS及MDA呈升高的趋势,PCr呈下降的趋势,其中CAL-LTVA的MDA显著高于其同行对照(P0.05)。ACO-LVTA组心室肌的MMP低于对照组,但高于CAL处理的两组。CAL-LVTA组血清cTnI高于对照组,且显著高于ACO-LVTA组及其对照与处理前(P0.01),ACO-LVTA组血清cTnI高于对照组与处理前。心肌ROS水平与VT及VF持续时间相关(P0.05),相关系数分别为0.44、0.46。结论发生LVTA后,心室肌MMP及PCr下降、ROS、MDA升高,血清cTnI升高,表明LVTA可导致能量代谢改变及氧化损伤,可能与线粒体功能异常相关。     

浅析不动产预告登记制度——兼论我国预告登记制度的完善

预告登记是起源德国普鲁士法的一项古老制度,其旨在保护以不动产物权变动为目的的债权请求权,因其在保障不动产交易安全、促进交易效率等方面发挥了非常重要的作用,后被许多国家和地区采用。我国于2007年10月1日施行的《中华人民共和国物权法》正式确立了不动产预告登记制度,但是它在实践中还存在许多不足,亟待解决。     

论法律变迁的价值指向——从户籍制度改革切入

法律的产生和变迁是为了提高社会合作效率,获取更多收益。法律变迁通过降低交易成本、外部收益内部化的具体价值目标,追求整体和长远效率。为了提高合作效率,法律还必须保障公平。法律变迁也是公平与效率由分离走向统一的过程。我国目前进行的户籍制度改革,以及与此相关联的其他制度改革都可以反映出法律变迁追求的价值。     

和谐社会构建过程中收入公平实现的路径选择——从效率与公平关系的角度分析

实现社会公平是发展中国特色社会主义的重大任务,要从社会发展的整体目标来把握效率与公平的关系,大力发展经济,健全社会主义市场经济体制,完善社会分配机制,完善社会保障制度等途径来实现收入公平,从而更好地体现社会公平正义。     

谈目标轨迹在侦查思维中的应用

目标轨迹,是指与刑事案件相关的物证和信息,依据发生的时间顺序,建立方向性的连接,构成点与射线组成的图形。目标轨迹能够将事物的过去、现在和将来联系起来,是侦查思维的外化和表现,它通过对犯罪嫌疑人实施犯罪阶段前后的活动情况进行分析、研究,有助干侦查人员把握侦查的主动权,提高侦查工作效能。文章从侦查思维的角度出发,阐释了目标轨迹在侦查工作中的价值、作用和意义。     

Russia’s energy relations in Southeastern Europe: an analysis of motives in Bulgaria and Greece

Although officially Russian state-owned energy companies operate as independent entities, their actions often lead to suspicion that they are acting as a tool of Russian state foreign policy. Countries on the southeastern borders of Europe – Bulgaria and Greece – are prime examples of where this might be the case, since they not only have a central position in Russia’s plans to penetrate European markets through new transport infrastructure but are also part of competing plans for routing non-Russian gas to Western markets. The main focus of the present research is on the natural gas and oil sectors, as these are the traditional foundation of Russian energy exports to Europe. The aim of this paper is thus to provide an objective, evidence-based analysis of Russian activities in the natural gas and oil sectors of Greece and Bulgaria in order to establish whether its actions have been implicitly or explicitly politicized and have served to strengthen Russian influence in the region.     

Winners, Losers, and Efficiency: Achieving Multiple Goals in Japan's Financial System Reforms

When giving policy advice, economists often proceed as if efficiency is the only valid social goal. Although efficiency is important, we argue that single-minded pursuit of it is counterproductive. It unnecessarily erects political hurdles to the enactment of efficiency-enhancing reforms because policy proposals that ignore valid, nonefficiency concerns are more likely to meet political and bureaucratic resistance. Moreover, such resistance may be avoided. A number of design principals can be employed to craft proposals that address political goals without abandoning efficiency. We describe three classes of principles: creative design of market mechanisms, maintenance of marginal incentives, and compensation for losers.We then illustrate their practical application in the context of Japanese financial-sector deregulation. This policy area usefully illustrates the importance of considering multiple goals in policy design. While efficiency is a frequently expressed goal, Japan's continued policy paralysis indicates that the bureaucratic and political goals of major stakeholders make the straightforward deregulation of financial markets difficult to achieve. We do not purport to resolve the entrenched barriers to economic reform in Japan, but to the extent that we identify and address valid nonefficiency goals, the conclusions of the analysis are relevant.     

邓小平效率公平思想的当下解读

"效率优先,兼顾公平"没有全面准确地体现邓小平同志的思想和党在分配问题上的指导原则。"效率优先,兼顾公平"尽管促进了社会财富增长,但也导致了居民收入差距扩大,使社会公平问题日益凸显。只有倡导"兼顾效率与公平"的理念,加强正确的政策引导,坚持高尚的价值导向,强化对非正常因素的调控,才能真正实现效率与公平的辩证统一,真正实现社会的进步与发展。     

中国发展低碳经济的路径选择

以低能耗、低污染、低排放为基础的低碳经济是人类社会的一大进步,国外已采取多种措施发展低碳经济。发展低碳经济,是中国做负责任的大国、实现和平崛起和可持续发展的必然选择。中国应采取多种措施发展低碳经济。     

浦东新区行政审批制度改革的现状与路径分析

经过四轮行政审批制度改革,浦东新区改革在审批事项的清理和审批方式的变革等方面取得了显著成效,但在行政体制、审批机制、审批效能和政府职能转变等方面仍存在一些困难和问题。为此,要以推进浦东综合配套改革试点为契机,进一步深化行政审批制度改革,努力建设公共服务型政府。