论应用ISO9000标准建立文档一体化质量管理体系

本文认为参照ISO9000国际质量标准,建立和健全档案质量管理体系是档案工作发展的一个珏然趋势。并通过对ISO9000标准的介绍来对档案工作如何建立质量管理体系提出建议。     

Isolation and identification of an isomeric sildenafil analogue as an adulterant in an instant coffee premix

The proliferation of adulterated health foods and beverages in the market demands a comprehensive analytical strategy to identify the adulterants, particularly those of isomeric phosphodiesterase 5 (PDE5) inhibitors. An instant coffee premix (ICP) purchased from an online retailer was flagged for suspected adulteration through PDE5 inhibition assay. The ICP was then analysed using suspected-target and non-targeted screenings of a liquid chromatography-quadrupole time-of-flight mass spectrometry. Based on these findings, a PDE5 inhibitor initially assigned as compound X was isolated from the ICP by employing a liquid chromatography-diode array detection before its structural elucidation with liquid chromatography-ultraviolet (LC-UV) spectroscopy and nuclear magnetic resonance (NMR) spectroscopy. The suspected-target screening matched the protonated molecule ([M + H]⁺) precursor ion of compound X at m/z 499.2310 with two suspected analytes that are structural isomers of one another. The fragmentation patterns of compound X were comparable to those analogues in the dithiocarbodenafil group through the non-targeted screening. These findings, complemented by the LC-UV and NMR spectroscopy data, together with the chromatographic separation of related structural isomers, conclude the identity of compound X. To our best knowledge, this is the first study to report the presence of 3,5-dimethylpiperazinyl-dithiodesmethylcarbodenafil in an ICP sample.

Key points

• The herbal-based male sexual performance products’ lucrative market has instigated their rampant adulteration, particularly with PDE5 inhibitors.
• The adulterated products may also contain analogues of the approved PDE5 inhibitors, which usually passed into the market undetected as they are not included in the routine targeted screening procedure.
• The present study detected, isolated, and identified an isomeric sildenafil analogue from an instant coffee premix sample using rapid qualitative assay and comprehensive analytical analysis.
• This paper highlighted the applicability of the established strategies for routine casework, particularly in a forensic drug testing laboratory.

     

Extended reality (XR) virtual practical and educational eGaming to provide effective immersive environments for learning and teaching in forensic science

Online virtual learning resources have been available for learning and teaching in forensic science for some years now, but the recent global COVID-19 related periods of irregular lockdown have necessitated the rapid development of these for teaching, learning and CPD activities. However, these resources do need to be carefully constructed and grounded in pedagogic theory to be effective. This article details eXtended Reality (XR) learning and teaching environments to facilitate effective online teaching and learning for forensic geoscientists. The first two case studies discussed in this article make use of Thinglink software to produce virtual learning and teaching XR resources through an internet system, which was delivered to undergraduate students in 2021. Case one details a range of XR virtual laboratory-based equipment resources, providing a consistent, reliable and asynchronous learning and teaching experience, whilst the second case study presents an XR virtual learning applied geophysics resource developed for a 12-week CPD training programme. This programme involves recorded equipment video resources, accompanying datasets and worksheets for users to work through. Both case studies were positively received by learners, but there were issues encountered by learners with poor internet connections or computer skills, or who do not engage well with online learning. A third case study showcases an XR educational forensic geoscience eGame that was developed to take the user through a cold case search investigation, from desktop study through to field reconnaissance and multi-staged site investigations. Pedagogic research was undertaken with user questionnaires and interviews, providing evidence that the eGame was an effective learning and teaching tool. eGame users highly rated the eGame and reported that they raised awareness and understanding of the use of geophysics equipment and best practice of forensic geoscience search phased investigations. These types of XR virtual learning digital resources, whilst costly to produce in terms of development time and staff resource, provide a complementary virtual learning experience to in-situ practical sessions, and allow learners to asynchronously familiarise themselves with equipment, environments and techniques resulting in more efficient use of in situ time. The XR resources also allow learners to reinforce learning post in-situ sessions. Finally, XR resources can provide a more inclusive and authentic experience for learners who cannot attend or complete work synchronously.     

国际和国家安全视角下的美国“星链”计划及其影响

星链计划是美国太空探索计划公司(Space X)提出的一项太空高速互联网通信计划,初衷是在地球的近地轨道建设卫星互联系统,进而为全球提供高速的互联网服务。然而,在星链计划的发展过程中,不断闪现着美国政府与军方的身影。星链计划发展也对应着美国太空安全战略转型的新模式,其目的在于实现由美国技术主导的、全覆盖的新一代"全球卫星互联网通信系统"。从技术和市场竞争层面上看,星链计划的实施对现存的5G通信技术和未来的天基互联网系统将产生重大的冲击和影响。从深层次的国际和国家安全角度看,星链计划背后依托的是美国高度成熟的军民融合体系和太空安全战略转型,将从国防、产业价值链、信息主权与监管、轨道与频谱资源使用、太空空间利用和天文探索等方面,对国际安全及其他国家的安全构成"复合型、交叉型"新挑战。     

"5+1+1"监狱管理教育罪犯模式的立法研究

在贯彻把刑释人员重新违法犯罪率作为衡量监狱监管工作的首要标准要求的过程中,形成了旨在提高监狱教育改造工作质量的“5＋1＋1”管理教育罪犯模式。“5＋1＋1”管理教育罪犯模式的创新之处在于把罪犯每周1天课堂学习教育固定化。“5＋1＋1”管理教育罪犯模式需要立法保障,使教育改造罪犯工作成为一项“硬任务”．进而不断发展完善。使监狱更好地履行所承担惩罚、教育和改造罪犯的重要职责,充分发挥监狱有效消除和减少社会不安全、不稳定、不和谐因素,维护社会和谐稳定的重要作用。     

Determinants and Evaluation of Local Energy‐Efficiency Initiatives from the American Recovery and Reinvestment Act

This article examines variation in local‐level energy‐efficiency grants and corresponding initiatives from the American Reinvestment and Recovery Act (ARRA) in the United States. The analysis is based upon a hurdle model of counts of energy‐efficiency grants received by 348 local governments that received these grants from 2009 to 2013, as well as 348 matched local governments that did not receive such funds. City‐level characteristics including amount of federal financial support, per capita income, signaling of preferences for sustainability policies, manufacturing, and political influences are shown to be empirically important determinants of variation in local energy‐efficiency initiatives. The evidence suggests that all else held equal, the $21.8 billion in ARRA funds expended with the intent of increasing local energy‐efficiency programs and policies successfully led to this end.     

Governance Arrangements for Transboundary Issues: Lessons from the Food Waste Programs of Italian Regions

Focusing on transboundary issues contributes to highlighting how new governance modes can emerge from increasing interdependence and complexity in public policies. This article analyzes food waste as a transboundary issue that cuts across different policy subsystems (PSs), intersects multiple levels of government, and calls into question consolidated policy making for new modes of governance. The analytical framework provides a multidimensional approach and a new typology of governance arrangements to be used in empirical research. Evidence from an Italian case study and an empirical investigation of 20 regional food waste programs shows that regions can adopt different driving ideas and can activate a variety of governance arrangements and differentiated, as well as viable, modes of integration between consolidated PSs. The article argues that different tool mixes combined with different levels of governance complexity may lead to a variety of governance arrangements and a differentiated likelihood of policy integration.