补体C_5在心肌梗死死后诊断的特异性研究

为了探讨补体 C5在心肌梗死死后诊断的特异性,应用免疫组织化学和图像分析技术 ,对正常心脏、心肌梗死及其它非梗死性的引起直接或间接心脏损害的情况如心肌炎、窒息、电击死、出血性休克、心挫伤、有机磷中毒等心肌细胞内 C5的变化进行研究。结果发现： C5仅在心肌梗死与心肌炎病例出现阳性反应,其阳性反应面积同正常对照组存在显著性差异,在窒息、电击死、出血性休克、心挫伤、有机磷中毒等病例未见明显阳性反应。因此 C5作为心肌梗死死后诊断指标仅受心肌炎的影响,对诊断心肌梗死具有较好的特异性。     

坚持理论创新加强党的建设

理论创新是马克思主义的本质要求,是马克思主义生命力的源泉.江泽民总书记在纪念建党80周年上的重要讲话,通篇洋溢着理论创新的精神,在一些重大问题上丰富和发展了马克思列宁主义、毛泽东思想和邓小平理论,是一篇马克思主义理论创新的典范.面向21世纪,要按照江泽民总书记"三个代表"重要思想的要求来加强党的建设,就必须高度重视和努力推进理论创新.     

用"三个代表"思想科学评价党的80年历史

用"三个代表"思想审视党的80年历史,无论是执政之前的革命时期,还是执政以后的建设时期,党之所以能够从曲折转向顺利,从失败走向成功,其主要原因是随着革命和建设实践的发展,党对"三个代表"所涉及的一些基本问题有了全面而又深刻的理解和认识,并在此基础上,创立了与中国革命和建设时期的基本国情相适应的、能够代表革命和建设时期中国各部分先进生产力发展要求和各部分人民根本利益的先进制度文化,即新民主主义先进制度文化和有中国特色的社会主义先进制度文化,从而把革命和建设引向了胜利.     

Asked and Answered: Knowledge Levels When We Will Not Take “Don't Know” for an Answer

A pivotal claim in research on citizen competence is that the typical citizen knows very little about politics. Public opinion surveys provide a considerable body of evidence in support of this position. However, survey protocols with respect to factual questions about politics violate established norms in psychometric research on educational testing in that don't know answers are encouraged rather than discouraged. Because encouraging don't know responses potentially confounds efforts to identify substantive understanding, this practice may lead to the systematic understatement of political knowledge. We explore this possibility with data drawn from three split-ballot tests: one conducted as part of a survey in the Tallahassee, Florida, metropolitan area, one conducted as part of the 1998 NES Pilot, and one conducted as part of the 2000 NES. Results reveal that the mean level of political knowledge increases by approximately 15% when knowledge questions are asked in accordance with accepted practices in educational testing.     

BAT在非离子型造影剂过敏反应中的诊断价值

目的通过测定免疫正常人、β-内酰胺类药物过敏者以及非离子型造影剂过敏者血液中CD63、肥大细胞羧肽酶A3(MC-CPA3)、人末端补体复合物SC5b-9,探讨嗜碱性粒细胞活化试验(basophil activation test,BAT)在非离子型造影剂过敏反应中的诊断价值。方法采用流式细胞术测定全血中嗜碱性粒细胞CD63表达率。采用ELISA法测定血清中MC-CPA3、血浆中SC5b-9含量。结果非离子型造影剂和β-内酰胺类药物过敏者血液中嗜碱性粒细胞CD63表达率、MC-CPA3以及SC5b-9含量均较免疫正常人升高(P0.05)。结论非离子型造影剂过敏者血液中嗜碱性粒细胞和肥大细胞发生活化,补体系统的激活也参与了非离子型造影剂过敏反应的发生。流式细胞术分析BAT可作为非离子型造影剂过敏反应的诊断方法。     

DRD5基因遗传多态性与精神状态的相关性及法医学意义

多巴胺是人类神经系统中重要的神经递质,通过与受体结合发挥生物学作用。当编码受体的基因异常时,可能导致精神疾病的发生。多巴胺受体有5种类型,分别为DRD1、DRD2、DRD3、DRD4、DRD5。DRD5是精神疾病的一个重要候选基因。DRD5受体基因上的rs7655090、rs1850744、(TC)n与精神疾病可能相关联;同时也存在矛盾的研究结果,表明精神疾病可能为多因素、多位点、多基因复制遗传疾病。DRD5基因的SNP具有较好的遗传多态性,可为法医学个人识别与亲权鉴定提供新的遗传标记及为司法精神病鉴定提供参考性遗传学指标。     

Voting for Movement Parties in Southern Europe: The Role of Protest and Digital Information

In recent years ‘movement parties’ such as Syriza in Greece, the Movimento 5 Stelle in Italy, Podemos in Spain and—to a lesser extent—Bloco de Esquerda in Portugal shook national party systems, breaking the consolidated dynamics of political competition. Despite growing interest in movement parties, there has been scant attention to the role of citizens adopting unconventional forms of action and using digital media in accounting for their electoral performance. To fill this gap, four original internet-based post-electoral surveys are employed showing that protesters and digital media users are more likely to vote for these parties, despite important country differences.     

Extending environmental justice research to religious minorities

For more than 30 years, significant research in the United States has found that racial and ethnic minorities suffer disproportionately from nearness to environmental disamenities compared with white non-Hispanics and that these results persist even controlling for poverty and “which came first,” the minorities or the disamenities. The engrained discriminatory findings of this environmental justice (EJ) research have led some to argue that we observe “systemic racism,” built into our social systems in ways that may be difficult to perceive. Yet, within the history of the United States, racial and ethnic minorities are not the only groups that have been systematically discriminated against; various religious groups also have histories of discrimination. Here we consider whether, holding constant race and ethnicity, some religious groups may also suffer from “EJ syndrome.” Since the US Census does not collect data on religion, to measure the presence of some religious groups that may be discriminated against, we use an original dataset on the presence of Jewish, Muslim, Church of Jesus Christ of Latter-day Saints (LDS, aka Mormon), and Roman Catholic houses of worship within California's Census tracts. Our results indicate that even controlling for race/ethnicity and income, the presence of Jewish or Muslim houses of worship in a California Census tract increases the likelihood of environmental burden as measured by the CalEnviroScreen 3.0 index of pollution and community vulnerability.     

The advocacy coalition framework in Japan: Contributions to policy process studies and the challenges involved

The advocacy coalition framework (ACF), a unified framework for understanding the policy process, has been applied in various countries and regions; however, there are few contributions from Japan, despite seemingly favorable conditions for applying it. An exploration of what hinders ACF applications in Japan is worthwhile for developing the ACF as a framework for comparative policy process studies across various social and political settings. Therefore, this study aims to systematically review previous Japanese ACF studies. Our review found that Japanese ACF studies are fewer in number, have less coverage of policy fields, and have less methodological diversity and transparency than international trends. While most of the Japanese ACF studies supported the basic hypotheses of the ACF, we found a need to refine some hypotheses and research methods of the ACF studies. We also discuss the background factors in the inactivity of ACF studies in Japan and suggest solutions for it.     

2004-2010年浙江省及其周边地区PRRSV GP5基因的分子进化与变异分析

用RT-PCR方法对分离自浙江省及其周边地区部分猪场的50个猪繁殖与呼吸综合征病毒(PRRSV)毒株和3个疫苗毒株的GP5基因进行了扩增、克隆和序列分析,并与国内外的代表性毒株进行了序列比对。结果表明,2004-2010年检测的PRRSV毒株均属于美洲型,大部分毒株属于亚群1,各毒株间的核苷酸和氨基酸同源性分别在81.6%～100%和72.1%～99.5%之间,浙江省及其周边地区亚群1毒株与我国最早分离到的美洲型毒株CH-1a的核苷酸和氨基酸同源性分别为84.5%～95.7%和78.6%～95.0%,与疫苗株的核苷酸和氨基酸的同源性分别为88.1%～99.2%和85.4%～99.0%。糖基化位点以及抗原表位都有一定程度上的变异。