新时期“东突”恐怖活动新动向及对策研究

近年来"东突"恐怖势力深受国际恐怖主义特别是中亚恐怖主义的影响,恐怖犯罪案件呈急剧上升态势。呈现出恐怖犯罪手段多样、残忍,并极力效仿国际恐怖主义,恐怖活动趋向采用"基地"组织的游击化运作方式,选择的作案时间与地点更具有策略性,恐怖分子本土化和组织化程度明显降低等特点。面对宗教极端思想的意识形态化,网络恐怖渗透的加剧和"伊吉拉特"的现实威胁日益加大的"东突"恐怖活动的发展趋势,我们必须树立全新的安全观,科学认识新疆反恐怖斗争的长期性、复杂性及艰巨性,建立健全反恐怖工作协调机制,加强情报信息工作,提高预知预防能力,加大出入境人员的管理力度,强化对可疑人员的甄别、核查力度,健全、完善网络、通讯监管法律体系,加强宗教事务管理,充分认识"伊吉拉特"活动的严重危害,加强意识形态领域的反分裂斗争,清醒认识中国面临的反恐困境。     

内含肽和麦芽糖结合蛋白介导具有抗病毒活性牛α干扰素的表达

为了在大肠杆菌表达系统中高效表达具有抗病毒活性的重组牛α干扰素(BoIFN-α)蛋白,在BoIFN-α基因的上游无缝连接内含肽Ssp DnaB intein(SDI)序列,然后克隆至pMAL-c2X载体中,构建含有内含肽和麦芽糖结合蛋白基因的表达载体pMAL-SDI-BoIFN-α,将重组载体转化至大肠杆菌Rosetta感受态细胞,IPTG诱导表达。结果表明,融合基因获得高效表达,且产物主要以可溶形式存在。经直链淀粉树脂纯化后可得到纯度较高的目的蛋白。经MDBK-BVDV(牛病毒性腹泻病毒)干扰素活性系统检测,证实干扰素融合蛋白具有抗病毒活性。     

中央苏区“八一”纪念初探

1933年,中共基于＂扩红＂与筹款的现实需要,在苏区开展了一场前所未有的纪念活动——＂八一＂中国工农红军纪念日活动。经由党、苏维埃、军委的组织与配合,举办了形式多样的纪念活动,进行了＂八一＂阅兵仪式的操演。这次纪念活动既实现了既定的政治动员目标,又透露出一种建构革命军队集体记忆的指向,由此奠定中共此后纪念活动的基本模式。     

司法能动的正当性分析

当下中国正经历着由传统社会向现代社会转型的历史进程.在社会转型时期,面对社会变迁和新型权益纠纷,司法者一味地恪守司法被动的原则并不能获得社会体认.司法者还需要在司法过程中发挥司法能动性,充分运用司法经验,合理行使裁判权,以解决纠纷.维护社会公平正义和秩序.但是,司法者的司法能动性并非是无限度的.司法者的能动司法,要获得社会体认的正当性,不仅要基于理性的判断,而且要遵循正当性的原理.一种具有正当性的司法能动,需要司法者在司法过程中做到合法性与合理性的协调,能动与被动的平衡,法律效果与社会效果的统一.     

Who is ready to climb the hill? The effect of legislative activity on promotion to higher offices in Chile

Previous research suggests that bill initiation is a mechanism used by legislators to foster personal votes. This article puts forward a theory whereby legislative activity is understood as a form of party service. Bill initiation records are used by parties to inform their decisions on who is ready to be promoted. The theory is evaluated using an original data-set from the Chilean Chamber of Deputies. Our empirical findings make a strong case for the hypothesis according to which parties reward those deputies who have shown to be effective legislators.     

The use of a quantitative structure-activity relationship (QSAR) model to predict GABA-A receptor binding of newly emerging benzodiazepines

The illicit market for new psychoactive substances is forever expanding. Benzodiazepines and their derivatives are one of a number of groups of these substances and thus far their number has grown year upon year. For both forensic and clinical purposes it is important to be able to rapidly understand these emerging substances. However as a consequence of the illicit nature of these compounds, there is a deficiency in the pharmacological data available for these ‘new’ benzodiazepines. In order to further understand the pharmacology of ‘new’ benzodiazepines we utilised a quantitative structure-activity relationship (QSAR) approach. A set of 69 benzodiazepine-based compounds was analysed to develop a QSAR training set with respect to published binding values to GABA_A receptors. The QSAR model returned an R² value of 0.90. The most influential factors were found to be the positioning of two H-bond acceptors, two aromatic rings and a hydrophobic group. A test set of nine random compounds was then selected for internal validation to determine the predictive ability of the model and gave an R² value of 0.86 when comparing the binding values with their experimental data. The QSAR model was then used to predict the binding for 22 benzodiazepines that are classed as new psychoactive substances. This model will allow rapid prediction of the binding activity of emerging benzodiazepines in a rapid and economic way, compared with lengthy and expensive in vitro/in vivo analysis. This will enable forensic chemists and toxicologists to better understand both recently developed compounds and prediction of substances likely to emerge in the future.     

Personal networks and crime victimization among Swedish youth

We combine routine activity theory, lifestyle-victimization theory, and a social network perspective to examine crime victimization. In particular, we study to what extent crime victimization is associated with having close contacts who have been victimized and/or who engage in risky lifestyles. We use the data (collected in 2014) of 1,051 native Swedes and 1,108 Iranian and Yugoslavian first- or second-generation immigrants in Sweden who were all born in 1990. They were asked to describe their personal characteristics, various behaviours, and past personal experiences with crime victimization, as well as those of the five persons with whom they most often spend their leisure time. Our findings support the network perspective: crime victimization is negatively associated with the number of close contacts an individual mentions but is substantially more likely for those who have many close contacts who have themselves been victimized. In terms of a risky lifestyle that may enhance the likelihood of being victimized, we found only that individuals who get drunk frequently were at somewhat higher risk of being victimized. To guard young individuals against crime victimization, it might thus be worthwhile to focus more on with whom they associate than on their potentially risky lifestyles or attitudes.     

大学英语课堂中的情景教学初探

情景教学适应了素质教育的趋势,为转变英语传统教学的弊端提供了新的思路。本文分析设置情景教学的方法以及应该注意的问题,并阐明了行之有效的对策。     

油樟叶乙醇提取物抗炎活性的研究

为探讨油樟叶乙醇提取物的抗炎活性,建立了用二甲苯诱导小鼠耳肿胀、醋酸诱导小鼠毛细血管通透性增加和角叉菜胶诱导大鼠足肿胀的模型,并测定了角叉菜胶所致大鼠足炎性渗出液中前列腺素E2、组胺和5-羟色胺的含量。结果表明,油樟叶乙醇提取物能显著抑制二甲苯所致的小鼠耳肿胀、醋酸诱导的小鼠毛细血管通透性增加和角叉菜胶所致的大鼠足肿胀,且呈剂量依赖性,并能显著降低角叉菜胶所致大鼠足炎性渗出液中前列腺素E2、组胺和5-羟色胺的含量。证实油樟叶乙醇提取物具有较好的抗炎活性。     

黄连多糖不同组分抗氧化活性比较研究

目的研究黄连粗多糖和带电量不同的黄连多糖组分的抗氧化活性。方法用二乙氨乙基纤维素(阴离子交换柱层析)分离纯化除蛋白后的黄连粗多糖,用Fenton法、邻苯三酚自氧化法和2,2-二苯基-1-苦味肼基(2,2-diphenyl-1-picrylhydrazyl,DPPH)分析法测定黄连粗多糖及纯化后带电量不同的多糖组分体外抗氧化作用。结果经阴离子交换柱层析,可获得4种带电量不同的黄连多糖组分,且这4种组分和黄连粗多糖对羟自由基、超氧阴离子和DPPH都有一定的清除作用,其中带电量高的组分对不同抗氧化模型均具有较高的清除作用。结论黄连多糖有一定的抗氧化活性,其抗氧化活性和其带电量具有正相关性。