大鼠脑损伤后EPO及其受体表达与损伤时间的关系

目的研究大鼠脑损伤后脑组织中促红细胞生成素(erythropoietin,EPO)及其受体(erythropoietin receptor,EPOR)的表达与损伤时间的关系。方法 72只SD大鼠随机分为对照组(36只)、脑损伤组(36只),在建模后1、2、4、8、12、24 h每组各取6只大鼠处死,取挫伤部位脑组织,应用实时荧光定量PCR和Western印迹法检测不同时间点EPO以及EPOR的mRNA表达和蛋白表达情况。结果伤后24h内,EPO及EPOR的表达随损伤时间的增加而呈上升趋势。EPO的mRNA及蛋白表达与损伤时间之间存在相关性,其相关系数分别为0.875、0.911(P0.05);EPOR的mRNA及蛋白表达与损伤时间之间存在相关性,其相关系数分别为0.936、0.905(P0.05)。结论大鼠颅脑损伤早期EPO及EPOR的表达呈逐步上升趋势,与损伤时间具有相关性,可以作为脑损伤时间推断的参考。     

PTEN在冠心病心肌组织中的表达

目的观察冠状动脉粥样硬化性心脏病(冠心病)患者心肌组织中人第10号染色体缺失的磷酸酶与张力蛋白同源基因(phosphatase and tensin homology deleted on chromosome ten,PTEN)的表达,探讨PTEN的表达与冠心病发生发展的相关性。方法选取经病理学确诊为冠心病死亡案例16例作为冠心病组,非心肌病变死亡案例19例作为对照组,采用免疫组织化学以及实时荧光定量PCR法检测心肌组织中PTEN蛋白及其m RNA的表达。结果冠心病组PTEN蛋白的表达量低于对照组(P0.05);与对照组相比,冠心病组PTEN m RNA表达的差异无统计学意义(P0.05)。结论 PTEN可能与冠心病的发生发展有关。     

电子商务中知识产权的法律保护

电子商务活动对社会的多个方面造成了很大的影响,也对传统的知识产权保护内容、保护方式、具体的原理及制度构建等方面提出了新的要求。在立法尚未完善的情况下,司法为拓宽电子商务领域知识产权保护做了一定的探讨。建立完善的电子商务自律机构和规则、逐渐完善相关的立法、加大对侵权行为的打击力度、协调国际上的知识产权保护,是发展电子商务并充分保护知识产权的有效途径。     

CBS在脑挫伤后损伤时间推断中的作用

目的观察胱硫醚β合成酶(cystathionineβ-synthase,CBS)在脑挫伤后皮质中不同时段的表达变化。方法利用改良的自由落体装置建立小鼠脑挫伤模型,通过Western印记法和免疫组织化学方法检测不同时间点(1 h、6 h、12 h、1 d、2 d、3 d、7 d)损伤区周围皮质CBS的表达变化。结果 Western印迹法显示,CBS在脑损伤后皮质中的表达下调,在损伤3 d时降到最低,于损伤7 d恢复到正常水平。免疫组织化学结果显示,CBS在正常皮质中有表达,损伤后表达逐渐减弱,损伤3 d后阳性表达明显减少,7 d恢复到正常水平。结论 CBS有望成为法医学推断脑挫伤后损伤经过时间的参考指标。     

执法权若干理论问题探究--兼对当前广义执法概念的质疑

执法权是任何国家最基本、最具活力的一项权力,它在国家权力配置过程中有着举足轻重的作用;同时,执法权科学配置与否直接与国家的兴衰、国家的法治建设水平息息相关.在我国,关于执法权的法律特性、执法权的产生与发展演变、执法权的不同设置模式等重要理论问题急需从法理学的视角进行深入探讨,以便为当前的政治体制改革,尤其是执法体制改革提供理论参考.     

THE INFLUENCE OF E‐GOVERNMENT ON ADMINISTRATIVE DISCRETION: THE CASE OF LOCAL GOVERNMENTS IN EGYPT

One important but often understudied area of research in public administration is the effect of e‐government on administrative discretion. This article examines e‐government factors that influence administrative discretion through a survey of local governments. The focus of this study is on Egyptian local governments, which are using e‐government to modernise public service delivery. Through a survey of administrative officials in these governments, this study found evidence that e‐government factors of collaboration and organisational change influenced administrative discretion. Other common factors noted in the literature such as size of the local government and demand by citizens for e‐government did not register an effect on administrative discretion. The results of this study imply that local governments should do more to enhance e‐government to reduce administrative discretion, especially in the area of increasing collaboration. Copyright © 2011 John Wiley & Sons, Ltd.     

视阈融合下晏殊词的思想价值探究

历来对晏殊词所体现思想价值的评价,褒贬不一。褒者重其艺术性,贬者据其内容立言。对于其词思想价值的评价也出现两个极端,褒者誉其“情思并致,圆融理性”,贬者讥其“富贵得意之余的无病呻吟”。从伽达默尔现代解释学视阈融合的角度切入,分别对这两种截然相反的观点进行梳理分析,集多维视角融合于一体,以期对晏词中所体现思想价值的理解适近真实。     

Politics and Corporate‐Sector Environmentally Significant Actions: The Effects of Political Partisanship on U.S. Utilities Energy Efficiency Policies

This study assesses the direct, indirect, and total impacts of political partisanship on state‐level utilities' investment in energy efficiency. This subject is of utmost importance because energy efficiency improvement has become a linchpin in worldwide efforts to combat climate change and other environmental challenges. Analysis of data on 51 electric utilities nested within 31 U.S. states indicates that political partisanship influences utilities' energy efficiency policies. There is strong evidence that electric utilities in states dominated by the Republican Party are less likely to invest in energy efficiency than those in states governed by the Democratic Party. This finding suggests that political partisanship may be shaping the policy and regulatory frameworks put in place by state governments to incentivize or compel the participation of private‐sector entities' in environmental management and/or resource conservation.     

邓小平理论视阈的主题与创新观

邓小平理论视阈的主题是探索建设中国特色的社会主义.在邓小平的语境中,其独具特色的创新观集中体现在对什么是社会主义、怎样建设社会主义这两大问题的一系列新识新论上.