复合扩增检测D9S302、D18S865和PLA2A基因座多态性

应用 PCR复合扩增技术、变性聚丙烯酰胺凝胶电泳和银染法显色检测技术,对云南省汉族人群 100名个体的 D9S302、 D18S865和 PLA2A基因座进行了研究,分别检出 10、 7和 7个等位基因,基因型频率分布均符合 Hardy－ Weinberg平衡,家系调查证实三基因座的传递遵循孟德尔遗传规律。三基因座累积个人识别率为 0.999 7,累积非父排除率为 0.992 9。证实了复合扩增 D9S302、 D18S865和 PLA2A三基因座是法医学个人识别和亲权鉴定中极有价值的检测方法。     

Third molar development in a London population of White British and Black British or other Black ethnicity

Population differences in dental development between Black and White ethnic groups have been debated but not previously studied in the UK. Using inappropriate data for dental age estimation (DAE) could lead to erroneous results and injustice. Data were collected from dental panoramic radiographs of 5590 subjects aged 6–24 years in a teaching hospital archive. Demirjian stages were determined for left-sided teeth and third molars and data collected regarding hypodontia and third molar agenesis. Third molar development in self-assigned Black British, including other self-assigned Black ethnicity, was compared with that of self-assigned White British subjects. Data were compared for males and females in the two ethnic groups using T-tests for Demirjian Stages A–G of third molar development and Mann-Whitney tests for Stage H once a cut-off age at the maximum age for Stage G had been imposed. Third molar development occurred earlier in subjects of Black ancestry compared to those of White ancestry. While both ethnic groups showed large age ranges for every third molar stage, in female subjects these generally occurred at least 1.5 years earlier, and in males at least one year earlier. Hypodontia and third molar agenesis were more prevalent in White British, but the ethnic difference in third molar development persisted in subjects with complete dentitions. This is a large study that confirms ethnic differences in a London population, emphasises the difficulties of establishing the 18-year-old threshold using DAE, and confirms the risk of overestimating the age of individuals of Black ethnicity using White ethnic reference data.     

全面深化改革的动力体系分析

改革开放是决定当代中国命运的关键抉择。改革只有进行时,没有完成时,全面深化改革是当代中国的必然选择。当前我国改革已经进入攻坚期和深水区,如何激发全社会的力量继续推进改革尤为重要。因果链条上促进社会发展的因素错综复杂,改革的动力不可能是单一的,而应该是一个多层次的动力系统。从全面深化改革的内部根本和直接推动力、理论对实践的指导动力、实践主体动力、上层建筑的反推动力四个层面对改革的动力体系进行系统的分析,对于处理当下多方面的矛盾和问题,集中各方力量全面深化改革有着极大的时代价值和实践意义。     

论法治型社会治理体制的构建——以十八届三中全会为背景

党的十八届三中全会将社会管理表述变为社会治理,是中国社会治道之变。鉴于法治是社会治理的根基,其中法治思维是社会治理基本思维模式,法治方式是现代社会的最优治理方式。所以法治型社会治理体制的构建是社会治理范式的历史性飞跃,它是民主加法治的完美组合升级版,是社会治理的简单化智慧,可挈领提纲的制度性化解问题,其终极目的是善治的达致。需明了的是,法治型社会治理模式是立足于"法律主治"的治理模式,承载着民众对生活世界幸福的美好向往,但它绝不是公民幸福的全部。     

Unusual FGA and D19S433 off-ladder alleles and other allelic variants at the STR loci D8S1132, vWA, D18S51 and ACTBP2 (SE33)

A very short FGA allele *14 and a long D19S433 allele *19.2 were detected and sequenced, as well as the new D8S1132 alleles *12.1, *14 and *15.1. Further new sequence data (vWA allele *18.3, D18S51 allele *11.2, SE33 alleles *24.2, *32, *34 and *37, including the rare variant allele *13.2) are described.     

Zu den Voraussetzungen der Verbindungspflicht von Verfahren auf Durchführung von Erhaltungsarbeiten (§ 6 MRG) und auf Erhöhung der Mietzinse (§ 18 MRG)

Eine Verbindungspflicht nach § 6 Abs 4 MRG besteht nur dann nicht, wenn der Vermieter die Notwendigkeit einer Erh?hung der Hauptmietzinse zur Finanzierung der schon verfahrensgegenst?ndlichen und der von ihm beabsichtigten anderen Erhaltungsarbeiten nicht schlüssig darlegen kann. Nur dann (oder im Fall von privilegierten Arbeiten) ist eine Beschlussfassung nach § 6 Abs 1 MRG ohne Verbindung mit einer Entscheidung über die Erh?hung der Hauptmietzinse zul?ssig. Wird kein Widerspruch von der Mehrheit der Hauptmieter und dem Vermieter gegen die beantragten Arbeiten iSd § 6 Abs 4 Satz 1 MRG erhoben, verbleibt dem Vermieter als einzige M?glichkeit zur Abwendung der Finanzierung der verlangten Erhaltungsarbeiten aus verrechnungsfreien Geldern die Antragstellung nach den §§ 18ff MRG, wobei eben diesfalls die Verfahren zu verbinden sind und noch weitere Erhaltungsarbeiten mit einbezogen werden k?nnen. Es ist dem Vermieter aber verwehrt, ohne ein solches Vorgehen die Abweisung des Antrags nach § 6 Abs 1 MRG mit dem Argument, dass noch weitere Arbeiten erforderlich w?ren, zu erwirken.     

党的十八大以来意识形态建设的伟大创新和基本经验研究

党的十八大以来,以习近平同志为核心的党中央把建设具有强大凝聚力和引领力的社会主义意识形态摆在全局工作的重要位置,作出一系列重大决策,实施一系列重大举措,既进行了彪炳史册的创新创造,取得了极其伟大的成就,也积累了丰富的宝贵的历史经验,在实践中不断深化对意识形态建设的规律性认识,为开启全面建设社会主义现代化强国新征程提供了坚强思想保证和强大精神力量。     

The Effect of Medical Marijuana Laws on the Health and Labor Supply of Older Adults: Evidence from the Health and Retirement Study

Older adults are at elevated risk of reducing labor supply due to poor health, partly because of high rates of symptoms that may be alleviated by medical marijuana. Yet, surprisingly little is known about how this group responds to medical marijuana laws (MMLs). We quantify the effects of state medical marijuana laws on the health and labor supply of adults age 51 and older, focusing on the 55 percent with one or more medical conditions with symptoms that may respond to medical marijuana. We use longitudinal data from the Health and Retirement Study to estimate event study and differences‐in‐differences regression models. Three principle findings emerge from our analysis. First, active state medical marijuana laws lead to lower pain and better self‐assessed health among older adults. Second, state medical marijuana laws lead to increases in older adult labor supply, with effects concentrated on the intensive margin. Third, the effects of MMLs are largest among older adults with a health condition that would qualify for legal medical marijuana use under current state laws. Findings highlight the role of health policy in supporting work among older adults and the importance of including older adults in assessments of state medical marijuana laws.     

羊源巴贝斯虫未定种甘肃敦煌株的发现

采用动物接种法将采自甘肃敦煌的15只绵羊血液混合后感染1只除脾绵羊,感染后逐日做血涂片检查。结果显示,在感染后第10天的血片上出现了1种大型巴贝斯虫。虫体形态以双梨子形、单梨子形、圆形及卵圆形为主。在感染后第12天,感染羊体温升至41.1℃。染虫率达到0.125%,之后逐渐下降。无菌采集该羊血液,提取全血基因组,用梨形虫通用引物进行PCR扩增全长18SrRNA基因,得到长约1 700bp的片段,将其克隆并测序(登录号:HQ730762),与GenBank中的其他巴贝斯虫的序列进行比较,发现其与新疆巴贝斯虫未定种的同源性最高,达到99.8%。本研究发现甘肃敦煌又是一个新疆羊巴贝斯虫未定种的疫源地。