Fatal Intoxication with α‐PVP,a Synthetic Cathinone Derivative

This study presents the fatal case of a young man who was admitted to the ICAU due to sudden cardiac arrest. An interview revealed that the patient had taken some unspecified crystals. From the moment of admission, his condition deteriorated dramatically as a result of increasing circulatory insufficiency. After a few hours, sudden cardiac arrest occurred again and the patient was pronounced dead. In the course of a medicolegal autopsy, samples of biological material were preserved for toxicology tests and histopathological examination. The analysis of samples using the LC‐MS/MS technique revealed the presence of α‐PVP in the following concentrations: blood—174 ng/mL, urine—401 ng/mL, brain—292 ng/g, liver—190 ng/g, kidney—122 ng/g, gastric contents—606 ng/g. The study also presents findings from the parallel histopathological examination. Based on these findings, cardiac arrest secondary to intoxication with alpha‐PVP was determined as the direct cause of the patient's death.     

Facial Age Synthesis Using Sparse Partial Least Squares (The Case of Ben Needham)

Automatic facial age progression (AFAP) has been an active area of research in recent years. This is due to its numerous applications which include searching for missing. This study presents a new method of AFAP. Here, we use an active appearance model (AAM) to extract facial features from available images. An aging function is then modelled using sparse partial least squares regression (sPLS). Thereafter, the aging function is used to render new faces at different ages. To test the accuracy of our algorithm, extensive evaluation is conducted using a database of 500 face images with known ages. Furthermore, the algorithm is used to progress Ben Needham's facial image that was taken when he was 21 months old to the ages of 6, 14, and 22 years. The algorithm presented in this study could potentially be used to enhance the search for missing people worldwide.     

长吉图开发开放先导区的区域引力与产业布局研究

长吉图开发开放先导区的成立,为东北亚的发展带来了新的机遇。虽然长吉图开发开放先导区内存在着两个经济中心,但延图龙地区的经济发展辐射能力明显低于长吉图。经过近十年的发展,使得长吉图的一体化趋势更加明显,该核心区的第二产业实力雄厚,第三产业发展相对落后;而延图龙核心区第二产业与周边地区产业发展存在脱离现象,未能实现优势互补,第三产业发展势头较好,但现阶段的辐射能力不足。因此,必须加大延图龙及珲春市的建设,推进另一个经济中心的快速增长;大力推进长吉图区域的交通建设,促进产业升级及转变产业增长方式。     

美国TPP战略的动机及其对东北亚经济一体化的影响研究

美国TPP战略既是美国外贸政策的重大调整,也是对WTO全球多边贸易秩序的系统性突破。它不仅反映了美国政府试图重振其国内脆弱经济的努力,同时也标志着美国亚太经济合作战略的重大转变。本文运用一般均衡模型,模拟了不同情境下美国TPP战略对不同地区产生的各种经济影响。模拟结果显示:TPP加入国家福利增加,而非加入国将受损,一个不包括中国的TPP将使得中国福利受损,贸易条件恶化。中国需要迅速建立包含中日韩三国的东北亚自由贸易区,同时应根据自己的长远利益构建针对美国TPP战略的其他对冲性政策。     

鸭瘟病毒gD基因胞外区的原核表达及ELISA检测方法的建立与应用

为研究分离鉴定的鸭瘟病毒gD基因(GenBank登录号:EU195085)及其编码蛋白的应用,采用PCR方法从鸭瘟病毒CHv毒株DNA中获取编码gD胞外区基因729bp片段,构建重组表达载体pET32a-gD,转化受体菌E.coli BL21(DE3),IPTG诱导表达重组gD蛋白。结果显示,该重组蛋白分子质量约为31ku,为gD胞外区与载体6个组氨酸的融合表达产物,与gD胞外区预期大小一致(27.5ku);经离心收集菌体,超声裂解后,SDS-PAGE分析结果显示,gD蛋白主要以包涵体形式表达;将包涵体溶解后进行Ni-NTA亲和层析可较好地纯化重组蛋白。Western-blot检测显示,gD蛋白能与兔抗鸭瘟病毒血清特异结合,具有较好的免疫反应性。利用该蛋白建立了ELISA检测方法,优化了该方法的各个反应条件,并进行了初步应用,为该方法的临床应用奠定了基础。     

民法典编纂中的立法模式悖论--基于商法规范如何安排的视角

在民法典立法中,商事法律处于何种位置?这一问题解决的好坏将直接关系到民法典立法的成败,甚至影响中国法治进程、影响中国市场经济的发展.中国大陆民事立法模式既非民商分立也非民商合一,在民法典立法思路上坚持民商合一的模式,却选择民商分立模式下的民法典作为范本,在逻辑上存在悖论.民法典立法不是要适当增加商法规则,而是要根据商事活动的需要,实现民法与商法的体系化,这完全是因为商法规则的特殊性决定的.民法典应该具有开放性,以适应复杂多变的现实.     

Biological protective factors of criminal offending: implications for risk assessment research and practice

Despite the recognition of the practical and theoretical contributions of protective factors in risk assessment practice, the field has granted significant attention to psychosocial protective factors to the apparent neglect of biological protective factors. This review found a wealth of evidence which strongly and convincingly indicates that biological factors such as high intelligent quotient, executive functioning, skin conductance, and resting heart rate offer protection against criminal and antisocial behaviors. More importantly, the literature is supportive of the view that both risk and protective factors co-occur in the same variables, thus questioning the practice of classifying a set of variables as strictly risk or protective. Specifically, the risk–protective effect is contingent upon individual’s rating as high or low on the factor in question. It is recommended that researchers, academicians, and practitioners strive in their efforts to canvass other salient factors beyond the psychosocial factors as these factors can significantly and positively impact the risk assessment field, both theoretically and practically.     

Evaluating interviews which search for the truth with suspects: but are investigators’ self-assessments of their own skills truthful ones?

Self-evaluation of one’s own performance has been found in prior research to be an enabler of professional development. The task of evaluation is also a core component of a model of the investigative interviewing of victims, witnesses and suspects, being increasingly used throughout the world. However, it remains the case that there has been little research as to how practitioners approach the task itself. The present study examined the topic through the lens of observing how effectively 30 real-life investigators in the UK undertook evaluation of their interviews, representing almost the entire investigative frontline workforce of a small law enforcement agency in this country. Using an established scale of measurement, both investigators’ and an expert’s ratings of the same sample of interviews were compared across a range of tasks and behaviours. It was found that in almost all the assessed behaviours, requiring of the investigators to provide a self-rating, their scores tended to significantly outstrip those applied to the sample by the expert. Reasons are explored for the investigators’ overstated assessments. Implications for practice are then discussed.     

大学英语教学改革的创新尝试——来自开展“英语寝室”活动的实践报告

"英语寝室活动与课堂教学互动"(Interaction between English Dormitory and Class-teaching)的改革创新,在实现多维互动教学模式、探索培养学生口语能力新途径的过程中迈出了坚实可喜的一步。本文将重点介绍这项改革的实施过程及取得的阶段性成果,并从第二语言习得理论和实践两方面阐述改革的重要意义,最后针对性地提出一些建议。     

A two-level model for evidence evaluation

A random effects model using two levels of hierarchical nesting has been applied to the calculation of a likelihood ratio as a solution to the problem of comparison between two sets of replicated multivariate continuous observations where it is unknown whether the sets of measurements shared a common origin. Replicate measurements from a population of such measurements allow the calculation of both within-group and between-group variances/covariances. The within-group distribution has been modelled assuming a Normal distribution, and the between-group distribution has been modelled using a kernel density estimation procedure. A graphical method of estimating the dependency structure among the variables has been used to reduce this highly multivariate problem to several problems of lower dimension. The approach was tested using a database comprising measurements of eight major elements from each of four fragments from each of 200 glass objects and found to perform well compared with previous approaches, achieving a 15.2% false-positive rate, and a 5.5% false-negative rate. The modelling was then applied to two examples of casework in which glass found at the scene of the criminal activity has been compared with that found in association with a suspect.