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排序方式: 共有110条查询结果,搜索用时 15 毫秒
31.
揭示人类自然群体中D8S384基因座的基因型频率,评估D8S384基因座在法医物证中的应用价值,以及建立D8S384基因座的分型方法。用不同基因型PCR产物混合的方法,制备了D8S384等位基因分型标准物,并按照国际法医血液遗传学会DNA委员会推荐的原则命名了等位基因。采用PCR扩增、电泳分析、银染显色的方法,调查了世界3大人种11个群体1103名个体的D8S384基因型。D8S384基因座共有8个等位基因,群体内基因型分布符合Hardy-Weinberg平衡,群体间基因型构成有显著性差异。利用群体数据估计了D8S384基因座的法医学理论应用价值,计算得出D8S384基因座的期望杂合度为0.704±0.014,个人识别机率为0.864。D8S384基因座是一个较好的法医学STR遗传标记。 相似文献
32.
Katherine H. Shelton Gordon T. Harold Tom A. Fowler Frances J. Rice Michael C. Neale Anita Thapar Marianne B. M. van den Bree 《Journal of youth and adolescence》2008,37(10):1216-1228
This study investigated genetic and environmental influences on the associations between mother–child relationship quality
(warmth and hostility) and adolescent conduct problems and cigarette use. Participants included 601 mothers and adolescent
twin pairs (aged 12–17 years). Mothers and adolescents provided separate reports of mother-to-child warmth and hostility.
A combined measure of mother and adolescent reported conduct problems was used while adolescents provided reports of their
cigarette use. Analyses were conducted using bivariate genetic analyses of correlated factors models and regression analyses
of monozygotic twin differences. Genetic influences were found for most ratings of the parent–child relationship, with evidence
of gender and/or rater-specificity for some measures. The relationship between mother–child hostility with adolescent conduct
problems and cigarette use was influenced by genetic and environmental effects. Evidence was found for shared environment
effects on the relationship between mother–child warmth and conduct problems. Examining monozygotic twin differences provided
further support for non-shared environmental influence on the relationship between mothers’ expressions of hostility and low
warmth and adolescent adjustment. Findings are discussed in relation to the interplay between genetic and environmental effects
underlying links between parent–child relations and adolescent behavior problems.
相似文献
Katherine H. SheltonEmail: |
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David W. Gjertson Charles H. Brenner Max P. Baur Angel Carracedo Francois Guidet Juan A. Luque Rüdiger Lessig Wolfgang R. Mayr Vince L. Pascali Mechthild Prinz Peter M. Schneider Niels Morling 《Forensic Science International: Genetics Supplement Series》2007,1(3-4):223-231
The Paternity Testing Commission (PTC) of the International Society for Forensic Genetics has taken up the task of establishing the biostatistical recommendations in accordance with the ISO 17025 standards and a previous set of ISFG recommendations specific to the genetic investigations in paternity cases. In the initial set, the PTC recommended that biostatistical evaluations of paternity are based on a likelihood ratio principle – yielding the paternity index, PI. Here, we have made five supplementary biostatistical recommendations. The first recommendation clarifies and defines basic concepts of genetic hypotheses and calculation concerns needed to produce valid PIs. The second and third recommendations address issues associated with population genetics (allele probabilities, Y-chromosome markers, mtDNA, and population substructuring) and special circumstances (deficiency/reconstruction and immigration cases), respectively. The fourth recommendation considers strategies regarding genetic evidence against paternity. The fifth recommendation covers necessary documentation, reporting details and assumptions underlying calculations. The PTC strongly suggests that these recommendations should be adopted by all laboratories involved in paternity testing as the basis for their biostatistical analysis. 相似文献
35.
张小勇 《中国青年政治学院学报》2007,26(2):78-83
遗传资源是对人类具有实际或潜在用途或价值的一类重要的生物资源,遗传资源的获取问题经历了从自由获取向限制获取的转变过程。《生物多样性公约》的通过,标志着遗传资源的获取和惠益分享国际法律规范的正式确立,而《粮食和农业植物遗传资源国际条约》则针对粮食和农业植物遗传资源的特殊性质建立了粮食和农业植物遗传资源的获取和惠益分享多边系统。 相似文献
36.
目的本研究的目的是了解人类基因组中D10S1432及D10S1213两个STR位点在成都汉族和甘肃东乡族群体中的遗传多态性分布及两个群体之间的关系。方法采用PCR、聚丙烯酰胺凝胶电泳及银染技术,共调查了209例样本。结果在D10S1432位点上观察到5个等位基因,15种基因型。在D10S1213位点上观察到9个等位基因,31种基因型。两位点的基因型频率在调查的两个群体中的分布符合Hardy-Weinberg平衡定律(P>0.05)。经统计,D10S1432在这两个群体中的杂合度为0.664和0.737,个人识别几率为0.827和0.820。D10S1213的杂合度为0.664和0.657,个人识别几率为0.836和0.882。结论结果表明,D10S1432和D10S1213两个位点在法医学个人识别和亲子鉴定中有较高应用价值。 相似文献
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When scientists use DNA evidence in court, coancestry effects such as population structure and relatedness are usually ignored. In paternity cases, only if a particular man has the child's paternal allele at a certain locus, can he not be excluded in the paternity dispute. However, it is certainly true that close relatives will be far more likely to have the child's paternal allele than will random members of the reference population. In particular, the probability that the true father's brother has the paternal allele is very much greater than that for any other relationship. In this paper, the authors describe a method for inference in a case where the true father may be a relative of the alleged father. This paper also reports that most current methods overstate the probability that the alleged father is the father. 相似文献
39.
河南汉族群体6个STR基因座遗传多态性研究 总被引:1,自引:0,他引:1
目的 通过研究 6个STR基因座FGA ,TPOX ,D3S135 8,vWA ,D8S1179,D2 1S11的遗传多态性 ,了解它们在河南汉族人群中的多态分布 ,与其他群体进行比较 ,得出遗传距离 ,并了解它在法医学中的应用价值。 方法 采用多聚酶链式反应扩增这 6个基因座 ,采用非变性聚丙烯酰氨凝胶电泳银染显色分析。 结果 得出这 6个基因座在河南汉族人群中的基因频率 ,并计算得出杂合度、个体识别率、非父排除率 ,与其他群体比较得出进化距离。 结论 这 6个基因座有较高的杂合度 ,并且具有相对遗传稳定性 ,在人群中的分布符合Hardy -Weinberge平衡 ,有较高的法医学价值 ,可以应用于个体识别和亲权鉴定。 相似文献
40.
《Forensic Science International: Genetics Supplement Series》2013,4(1):e73-e74
In order to increase the information about Indels, we report allele frequencies and statistical parameters of forensic efficiency obtained typing a sample of 114 unrelated healthy individuals living in San Basilio de Palenque – Colombia using a panel of 38 autosomal InDels. No significant deviations from Hardy–Weinberg expectations were found except in the marker rs10629077 (p = 0.0002). The present database will be useful for forensic and paternity purposes for the region studied. Moreover, these additional markers can help forensic laboratories to solve parentage testing as well as to improve the analysis of degraded DNA samples. 相似文献