Acidic and neutral drugs screen in blood with quantitation using microbore high-performance liquid chromatography–diode array detection and capillary gas chromatography–flame ionization detection

Blood previously acidified with aqueous saturated ammonium chloride solution was extracted with ethyl acetate. The dried extract was subjected to acetonitrile–hexane partition. The acetonitrile portion was analysed for the presence of acidic and neutral drugs by HPLC–DAD (200 mm×2.1 mm I.D. microbore ODS-Hypersil column) and GC–FID (25 m narrow-bore×0.25 mm I.D. HP-5 column with 0.33 μm film thickness). The protocol was found to be suitable for both clinical toxicology (including emergency toxicology) and postmortem toxicology. At least 66 drugs of interest were unequivocally identified by RRTs (HPLC) and UV spectra (DAD) match while another 12 were unequivocally identified by double RRTs match (HPLC and GC). Quantitation was facilitated by incorporating calibration blood standards in each assay batch. The five drugs most commonly encountered in clinical blood specimens (1150 cases) were: paracetamol (47.4% of the cases); chlormezanone (6.6%), theophylline (1.74%), naproxen (1.65%) and mefenamic acid (1.56%). The following drugs were detected in toxicologically significant quantities in postmortem blood specimens (245 cases): phenobarbitone (1.22% of the cases), naproxen (0.82%), chlormezanone (0.82%), theophylline (0.82%), carbamazepine (0.41%) and paracetamol (0.41%).     

医疗责任保险制度初探

笔者从医疗风险、医疗责任保险的可保性及医疗责任保险的性质与意义等方面多角度的进行详细的论述,对医疗责任保险制度在国内外的发展及现状进行了较为客观的分析,最后结合我国实际,在借鉴国内外成功经验的基础上提出了我国建立医疗责任保险制度的初步构想。     

我国城镇失业率已进入风险区

深化改革和需求不足等原因造成我国城镇失业增加。德尔菲法研究结果显示 ,我国城镇真实失业率水平为 7% ,已达到警戒线 ,且近年会有较小幅度的增加。建议政府设立专职机构 ,对失业风险监测与调控     

A Test of Generalizability of the Social Development Model Across Gender and Income Groups with Longitudinal Data from the Elementary School Developmental Period

The social development model (SDM) is a theory of behavior that has proven useful in explaining the etiology of delinquency, violence, and substance use among adolescents as well as early antisocial behavior among pre-adolescents. A further test of the model is its generalizability across population groups. A section of the SDM representing prosocial influences in the etiology of problem behavior was compared for boys and girls and for children from low- and non low-income families using three waves of child, parent and teacher survey data on a sample of 851 elementary school students. Multiple group structural equation modeling was used to assess differences across groups in both measurement of model constructs and hypothesized structural paths between constructs. The results indicate overall similarity in the reliability of measurement models and validity of structural models.     

我国企业年金制度存在的问题及对策

《企业年金基金管理试行办法》的出台,标志着我国养老社会保障制度建设终于走向了国际化发展轨道,从我国企业年金的基本状况出发,分析了企业年金制度发展缓慢的因素,提出了完善中国企业年金制度发展的对策。     

ON BEING A CHILD CUSTODY EVALUATOR: PROFESSIONAL AND PERSONAL CHALLENGES,RISKS, AND REWARDS

Conducting child custody evaluations is one of the most complex, challenging, and sometimes risky professional endeavors that a mental health professional can perform. This article examines the professional and personal challenges which may be encountered by the evaluator. In addition to discussing the role requirements and need to maintain awareness of bias and countertransference, challenges such as coping with state board or ethics complaints and possible risks to personal safety are also addressed. Suggestions for risk management and coping with the demands of these assessments are offered, as well as the benefits and rewards of engaging in this important work.     

8例利多卡因过敏性休克死的血药浓度分析

目的研究利多卡因过敏性休克死者利多卡因血药浓度及其与死因的关系。方法采用高效液相色谱法(HPLC),分别对使用利多卡因麻醉术中各项指标均正常的8例术中因利多卡因过敏性休克死者的血液和11例顺利完成手术患者的血液进行利多卡因浓度的检测,对比分析两者结果。结果 8例死者利多卡因血药浓度(1．61mg± 0．45mg／L)低于11例正常患者利多卡因血药浓度(2．44mg±0．47mg／L)。结论利多卡因过敏性休克死者血药浓度在正常值范围内,与发生过敏性休克致死无关。     

保险利益原则及其应用

保险利益既非经济利益也非关系利益更非法律利益 ,而是指可以转嫁的不确定的风险。财产保险利益以可能损害为量化标准 ,人身保险利益以合同当事人的约定为依据。保险利益的主体应当是被保险人而非投保人。保险利益原则的确立是保障保险活动健康发展的前提     

2004年银行监管展望

2004年银行监管要在坚持法人监管、风险监管、内控监管和透明监管的新理念指导下,努力实现监管战略的七大转变和监管体系的四个完善;认真履行世贸承诺,加强外资银行监管,扩大国际金融监管合作.     

论《外资金融机构管理条例实施细则》的修订

随着我国银行业的进一步对外开放和监管法律框架的不断完善,为促进外资金融机构的安全、健康发展,我国对原《外资金融机构管理条例实施细则》进行修订和完善。本文从新《细则》的修订入手,通过比较我国和美国监管法的不同,论述了新《细则》修订的必要性、科学性及前瞻性。