Distribution and metabolic pathway of flualprazolam in rat

Objective To probe into the distribution and metabolic pathway of flualprazolam plus its main metabolite (α – hydroxylflualprazolam) in rat. Methods 40 SD rats were randomly divided into 4 groups and fasted for 12 hours, with the first group being fed of flualprazolam by gavage as per 0.45 mg/kg and having their respective blood collected from tail vein at different time and each one’s urine received every day after administration. The second group was taken as the blank control to the first one. The third group was executed at 0.25h after drug administration, having their respective blood, heart, liver, lung, kidney, brain, spleen and muscle collected and extracted with rapid solvent extraction. The fourth group was the blank control against the third one. The distributing and metabolizing flualprazolam and α-hydroxyflualprazolam were detected through HPLC-MS/MS. Results Flualprazolam was found of rapid distributing and metabolizing in rats, reaching its highest blood concentration within 0.25h, having shown its sequential distribution in various organs as follows: kidney > brain > heart > liver > spleen > muscle > muscle > lung > blood. Yet, α-hydroxyflualprazolam demonstrated its discrepant organ-specific distributing order: liver > kidney > heart > spleen > lung > muscle > blood > brain. Conclusion The experiment has showed the distribution and degradation of flualprazolam and its main metabolite in rats who were administered of flualprazolam by gavage, capable of providing scientific basis for flualprazolam to test in vivo and have its metabolic pathway analyzed. © 2021, Editorial Office of Forensic Science and Technology. All rights reserved.     

试论证明责任分配规则

证明责任具有主观证明责任与客观证明责任双重含义。证明责任制度的核心是证明责任分配。大陆法系国家通常采用形式标准,英美法系国家一般采取实质标准来分证明责任。最高人民法院颁布的《关于民事诉讼证据的若干规定》借鉴两大法系的优势,制定出适用我国的三项证明责任分配规则:基本规则、特殊证明责任分配和衡平原则。     

公共教育资源配置失衡及其政策补给——以湘南H区2005年的相关教育数据为分析样本

教育公平一直以来是中国公共管理领域重点讨论的话题。公共教育资源分配不均衡和教育服务的不充分与不对等是造成教育不公的主要原因。以2005年湘南H区义务教育状况为样本,运用实地调查和统计分析的研究方法,从教育财政资源、教师资源、学生资源三个方面分析了当前地方公共教育资源配置失衡的状况及其原因。由于长期实行城市偏向的教育政策和重点校制度,形成了农村教育和城市教育以及"重点学校"和"普通学校"的天壤之别,从而导致了公共教育资源配置失衡和公共教育的不平等。因此,要最终促进公共教育的均衡发展和公共教育服务的均等化供给,必须纠正原有的政策偏差,进一步统筹城乡发展,加大农村教育投入力度,确保农村教育投入的优先性;必须打破原有办学特权,实现办学点和生源的均衡配置;必须实施鼓励和优惠政策,避免城乡教育"马太效应"的持续恶化。     

Foreclosure filings and sheriff's sales experienced by low‐income first‐time home buyers

Abstract

This paper examines the recent history of supply‐side subsidies. The first section describes the programs that have had a major impact on the supply of low‐income housing over the last 20 years. The second section looks in some detail at the recent history of tax subsidies to low‐income housing and attempts to quantify their magnitudes. The third section presents some data on recent syndication deals to shed light on the return rate that seems to have been required in recent years to attract private investors into low‐income housing. The final section turns to the literature on rent‐seeking behavior and proposes a more efficient way to subsidize low‐income housing production.     

Comment on Charles C. Bohl's “new urbanism and the city: Potential applications and implications for distressed inner‐city neighborhoods”

Abstract

This article argues that distressed neighborhoods greatly benefit from New Urbanist design. New Urbanists have been rebuilding distressed neighborhoods for years, and New Urbanism's mix of architecture, planning, and public policy offers inner‐city neighborhoods the best set of tools available to improve the quality of life for their residents. Principles based on flexibility and absolute rejection of formula allow New Urbanism to offer solutions for a broad range of situations.     

非劳动收入问题论析

不沿用"资本剥削"的概念,并不是背离马克思剩余价值的理论;非劳动收入是对私营企业主等新的社会阶层合法收入的新概括,比"资本剥削"更合理更科学地说明了他们的实际收入。     

按生产要素分配小注

党的十五大以后,我国理论界开始了关于按生产要素分配种种问题的讨论,有种观点认为,按劳分配本来就属于按生产要素分配,原来把生产要素分配和按劳分配对立起来的观点是理论上的误区。本文对此观点持有异议,认为按生产要素分配并不包括按劳分配,二者有着本质的区别。     

The labour market and income distribution in post-socialist economies – Non-obvious regularities

The goal of this paper is to analyse the major processes which took place on the labour market of post-socialist economies and to check what the outcomes of thee mechanisms used for income distribution. Few findings are especially interesting because of its counterintuitive character. First, there is a “strange” relation between the depth of recession and scale of rise in unemployment. Countries which suffered from quite moderate fall in GDP experienced high level of unemployment, while the economies which noticed substantial recession were able to sustain very limited unemployment rate. One can also expect that economy which suffered from sharp rise in unemployment should be the one in which income inequalities deteriorate in the biggest extend. Again, this is not what has happened in post-socialist countries. Economies like Russia or Ukraine which noticed quite limited rise in unemployment rates, experienced the highest deterioration in the income inequalities indicators. Finally, closer look at labour markets of EU New Member states shows that social cohesion in these countries is a much bigger problem than it appears from simple Gini coefficients.     

明治日本所得税法立法过程考论

明治中期开始,日本政府为实现其富国强兵政策,采取了一系列增强财政收入的措施,当时的大藏省在相继进行地税改革以及试图恢复关税自主权之后,仍然没有扭转财政入不敷出的状况。在此情况下,以松方正义等为首的大藏省官员效仿欧美国家,开始将新的税制引入日本。通过对当时欧美各国税制进行反复研究,决定引进当时只在英国等极少数国家实行的所得税制。近代日本为何引进所得税?又是如何完成对所得税法的立法程序?在此过程中如何处理外来制度与本国传统及实际的矛盾?文章试图解答这些问题。     

盐酸曲马多在大鼠体内的分布特点

目的观察盐酸曲马多在大鼠体内的分布及其特点。方法大鼠以3倍和6倍LD50228mg/kg剂量盐酸曲马多灌胃染毒致死,取材,薄层色谱法检测其心、肺、肝、脾、肾、大脑和血内盐酸曲马多的浓度。结果3倍LD50剂量组大鼠肾、肺、血、肝、大脑、脾和心组织盐酸曲马多的浓度分别为112±15、59±17、53±31、32±19.7、22±11.5、20±20、16.7±8.3μg/g或μg/ml;6倍LD50剂量组大鼠血、肺、肝、心、肾、大脑和脾中盐酸曲马多的浓度分别为107.6±7.2、26.3±20、11.7±6.6、11.2±7.2、10.3±3.6、6.38±0.2、6.1±0.3μg/g或μg/ml。结论3倍LD50剂量组大鼠,肾、肺、血内盐酸曲马多浓度最高;6倍LD50剂量组大鼠血、肺、肝中盐酸曲马多的浓度最高。盐酸曲马多中毒时,血、肝、肺和肾可以作为法医毒物分析的检材。