血中微量毒鼠强快速分析

目的建立血中毒鼠强快速分析方法。方法以高速离心并用有机溶剂直接提取血中毒鼠强,进行GC/MS、GC/NPD分析。结果有机溶剂以苯为提取液时结果最好。结论本方法操作简便,快速、准确、灵敏,适合办案。     

射击残留物检验确定发射枪支1例

1案情简介2005年1月22日晚,我省某县张某某与李某某各持一把自制猎枪前往山上打猎。当晚狩猎回来的路上李某某被近距离枪击致死。2检验2.1仪器EMPA-810Q电子探针显微分析仪(日本岛津制作所)2.2试样制备张某某与李某某各自所持的猎枪枪膛内的射击残留物用双面胶粘取(编号分别为A#及B#),同样方法提取张某某与李某某所持子弹袋中的空弹壳内的射击残留物(编号分别为A#-1及B#-1)。李某某面部右嘴唇上方弹孔周边的射击残留物(编号为C#)。以上样品用EMPA-810Q电子探针显微分析仪对射击残留物进行元素定性及硫、钾无标样定量分析,定量数据取5…     

鉴定科学LC-MS／MS多反应监测筛选分析血液中132种毒药物

目的建立血液中常见毒药物的LC-MS/MS筛选分析方法。方法采用多反应监测(MRM)模式,以目标物的保留时间和母离子／子离子对为指标进行筛选分析。建立LC-MS/MS 库和定性认定准则,并考察了方法的有效性。结果多反应监测筛选体系兼具有选择离子扫描的曼敏度和二级质谱的特征性,血液中132种毒药物筛选分析的最低检出限为0．1- 10ng/mL．其中83％的检出限≤lng/mL。鉴定应用表明方法的检出率和可靠性良好。结论该筛选分析方法能满足法医毒物学和临床毒物学检测中毒或治疗浓度目标物的需要,且能扩展至其它生物检材。     

An evaluation of the outsourcing IS/ICT activities in Turkish ministerial computer departments

Outsourcing an IS/ICT function has become fashionable in public administration reform. Through this modality, many organisations are cutting staff costs and increasing efficiency. Financial benefits can be great, public organisations can in fact expand IT usage and hence avoid obsolescence. Despite the benefits of outsourcing IT, there are risks involved. Public organisations need to weigh the benefits, risks and costs involved before making decisions to outsource. Recently, Turkish public organisations have been increasingly outsourcing functions such as facilities maintenance, catering, security and IS/ICT activities. This article, based on a field study, undertakes an evaluation of the experience of Chief Information Officers (CIO's) in outsourcing of IS/ICT activities in ministerial computer departments. The findings provide important lessons for outsourcing in Turkey and elsewhere. Copyright © 2008 John Wiley & Sons, Ltd.     

尿中苯丙胺、甲基苯丙胺、MDA和MDMA的固相微萃取和GC/MS/SIM测定

目的研究固相微萃取(SPME)用于尿中苯丙胺(AMP)、甲基苯丙胺(MET)、3,4-亚甲二氧基苯丙胺(MDA)和3,4-亚甲二氧基甲基苯丙胺(MDMA)的提取。方法样品调节至碱性和用盐饱和后用顶空SPME,内标为MET-d5。萃取纤维为100μm聚二甲基硅氧烷(PDMS)。用气质联用选择离子检测(GC/MS/SIM)。结果0.2μg/ml加标尿样,AMP、MET、MDA和MDMA的富集倍数分别为22,60,13和47。检出限(S/N=3)为0.4～9.5ng/ml。线性范围为0.05～1μg/ml。0.2、0.5和1.0μg/ml加标尿样,相对回收率77.9%～112.4%,变异系数2.7%～18.0%(n=5)。用该方法分析5个案件样品,和常规液液萃取结果接近。结论顶空SPME法用于尿中AMP、MET、MDA和MDMA等化合物的分析,无需有机溶剂,富集效率高,提取-富集-进样一体化,简单方便实用。     

The Application of Missing Data Estimation Models to the Problem of Unknown Victim/Offender Relationships in Homicide Cases

Homicide cases suffer from substantial levels of missing data, a problem largely ignored by criminological researchers. The present research seeks to address this problem by imputing values for unknown victim/offender relationships using the EM algorithm. The analysis is carried out first using homicide data from the Los Angeles Police Department (1994-1998), and then compared with imputations using homicide data for Chicago (1991-1995), using a variety of predictor variables to assess the extent to which they influence the assignment of cases to the various relationship categories. The findings indicate that, contrary to popular belief, many of the unknown cases likely involve intimate partners, other family, and friends/acquaintances. However, they disproportionately involve strangers. Yet even after imputations, stranger homicides do not increase more than approximately 5%. The paper addresses the issue of whether data on victim/offender relationships can be considered missing at random (MAR), and the im-plications of the current findings for both existing and future research on homicide.     

Participatory action research into donor–recipient relations: a case study

This article describes the exploratory and preparatory phase of a research project designed to use co-operative enquiry as a method for transformative and participatory action research into relations between donors and recipients in two developing countries, Bolivia and Bangladesh. It describes the origins of the idea, the conceptual challenges that the authors faced in seeking funding, and what they learned from this first phase. The authors analyse why the researchers, as well as the potential subjects of the research, were uncomfortable with the proposed methodology, including the challenges arising from their own positions and the highly sensitive nature of the topic. They explain why they decided to abandon the project, and they reach some tentative conclusions concerning the options for participatory action learning and research in development practice.     

从苏/俄政治转型看现代政党政治的发展趋势

俄/苏在特定的历史条件下建立了多党联合政权,又在特定的历史条件下走向了一党统制。但这条路终究没有走通。苏共随着前苏联的解体而走到其历史的尽头,俄共则随着俄罗斯多党制的确立而浴火重生———虽然处境艰难,却也不失为俄罗斯政坛的一支重要力量。苏/俄政党政治的演变说明,只有基于合法竞争的适应政治民主潮流的政党政治,才有生命力;政治权力的垄断不仅会侵犯作为权力所有者的人民的根本利益,而且对权力的垄断者也是绞索。     

LC-MS/MS同时分析血液中五种巴比妥类药物

目的建立血液中巴比妥类药物液相色谱-串联质谱(LC-MS/MS)检测方法。方法血液中的巴比妥类药物用有机溶剂液-液萃取,以乙酰水杨酸为内标,LC-MS/MS测定。结果检测血液中五种巴比妥类药物的最小检出限(LOD)均为10ng/mL,线性范围在0.02￣10μg/mL内良好,方法的回收率70%￣87%。结论所建方法快速、灵敏、准确,可以满足临床毒物和法庭毒物分析的需要。     

五氟丙酰衍生化-气相色谱/质谱联用法分析尿液中7-氨基硝西泮

目的用五氟丙酰衍生化-气相色谱/质谱联用法分析尿液中硝西泮的主要代谢物7-氨基硝西泮。方法尿液经乙醚萃取后,用五氟丙酰酸酐(PFPA)进行衍生化,得到7-氨基硝西泮衍生化物的总离子流色谱图和质谱图。结果根据7-氨基硝西泮衍生化物色谱的保留时间和质谱中主要特征离子的质荷比进行定性分析;用7-氨基氟硝西泮做内标,以7-氨基硝西泮和内标衍生化物定量离子的色谱峰面积比与浓度的关系进行定量分析。结论用五氟丙酰衍生化-GC/MS分析尿液中硝西泮的主要代谢物7-氨基硝西泮的方法定性、定量灵敏准确,测定结果可应用于司法鉴定。