Detection of trace drugs of abuse in baby formula using solid‐phase microextraction direct analysis in real‐time mass spectrometry (SPME‐DART‐MS)

The intentional or unintentional adulteration of baby formula with drugs of abuse is one of the many increasingly complex samples forensic chemists may have to analyze. This sample type presents a challenge because of a complex matrix that can mask the detection of trace drug residues. To enable screening of baby formula for trace levels of drugs, the use of solid‐phase microextraction (SPME) coupled with direct analysis in real‐time mass spectrometry (DART‐MS) was investigated. A suite of five drugs was used as adulterants and spiked into baby formula. Samples were then extracted using SPME fibers which were analyzed by DART‐MS. Development of a proof‐of‐concept method was completed by investigating the effects of the DART gas stream temperature and the linear speed of the sample holder. Optimal values of 350°C and 0.2 mm/s were found. Once the method was established, representative responses and sensitivities for the five drugs were measured and found to be in the range of single ng/mL to hundreds ng/mL. Additional studies found that the presence of the baby formula matrix increased analyte signal (relative to methanolic solutions) by greater than 200%. Comparison of the SPME‐DART‐MS method to a traditional DART‐MS method for trace drug detection found at least a factor of 13 improvement in signal for the drugs investigated. This work demonstrates that SPME‐DART‐MS is a viable technique for the screening of complex matrices, such as baby formula, for trace drug residues and that development of a comprehensive method is warranted.     

Detection of Cutting Agents in Drug‐Positive Seized Exhibits within the United States

The following report summarizes a study performed on seized drug exhibits collected in two U.S. states to evaluate the presence and identification of cutting agents. Aliquots of seized drug materials from Kentucky (n = 200) and Vermont (n = 315) were prepared using a dilute‐and‐shoot procedure. Initial analysis was performed using gas chromatography–mass spectrometry (GC‐MS) followed by analysis using liquid chromatography quadrupole time‐of‐flight mass spectrometry (LC‐QTOF). Active compounds detected overall included caffeine (31.0%), quinine/quinidine (24.7%), levamisole (11.6%), acetaminophen, (8.2%) and procaine (8.2%). These compounds were found with several drugs of abuse, such as heroin, fentanyl, methamphetamine, and cocaine. This novel information about cutting agents used to dilute or alter drugs of abuse is important to criminal investigations and in the management of acute intoxications at health centers. However, common methodologies for analysis and standard reporting practices frequently do not include cutting agents, resulting in lacking or inadequate information regarding prevalence of these substances.     

Political competition and foreign policy power sharing

In this essay I examine the intersection of domestic and international politics in the formation and conduct of foreign policy. 1 develop a three‐actor model that allows us to specify the incentives for power sharing under different assumptions about the distribution of preferences and capabilities between a government, a domestic opposition, and a foreign state. The model generates several interesting hypotheses about the interaction of policy goals and the willingness of actors to share power. In particular, I show that under certain conditions there are important asymmetries whereby doves may be more willing to share power than hawks. Importantly, this willingness is endogenous to the model and comes from the alignment of preferences in the policy space, rather than from an a priori value for the democratization of foreign policy making. The model also suggests several hypotheses about the circumstances under which states have incentives to meddle in the foreign policy processes of other states.     

Estimating between‐ and within‐cluster covariate effects,with an application to models of international disputes

Students of international politics often use data in which the covariates vary both within and across units of observation. This is particularly true for dyadic data, which has come to dominate quantitative studies of international conflict, but is also a concern in any work involving a time‐series cross‐sectional component. Standard regression methods treat both types of covariates as equivalent with respect to their influence on the dependent variable, ignoring possible differences between cross‐dyad and within‐dyad effects. Here, I discuss the potential pitfalls of this approach, and show how between‐ and within‐dyad effects can be separated and estimated. I then illustrate the approach in the context of a logistic regression, using data on international disputes.     

The tyranny of distance: Redefining relevant dyads

A variety of definitions of “crisis” plague the study of international crisis. The purpose of the paper is to demonstrate the reasons for the divergence and a possible solution to the problem.

Definitions of “crisis” tend to incorporate a variety of elements. Some focus on the micro‐level of decisionmakers in particular countries; others look at the macro‐level of international system change; still other definitions are multi‐level, incorporating both micro‐ and macro‐components. A second set of differences is rooted in metaphysical assumptions. Some definitions look at “crisis” as something recognized by the mind of the individual, a perceptual process that is basically mental; other definitions, which tend to equate “crisis” with “stress,” assume that “crisis” is a physical phenomenon that can be measured by information flows, physiological tensions, or other objective observable behavior. A dualist approach insists that “crisis” is simultaneously physical and nonphysical is also evident in the literature. A third aspect of “crisis” definitions is whether the researcher seeks to stipulate an arbitrary meaning for the term on the basis of supposed self‐evident logic or whether data are collected prior to an effort to define the term; this is the familiar distinction between rationalism and empiricism, with facet theory as an approach that combines elements of both approaches.

Various approaches attempt to test theories of “crisis” with definitions determined by their metaphysical foundations. The models identified are as follows: hostile interaction, individual stress, physiological overload, organizational response, and cost calculation. Findings based on various empirical tests of the theories show that there is very little agreement in the literature on variables associated with “crisis”; more often than not, if a variable is linked with “crisis” positively in one study, the same variable is either linked negatively or has no correlation with “crisis” in a second study. The source of the empirical divergence may be that the various studies sample different cases—or differing definitions may account for the lack of consensus in the field.

The paper concludes by urging that research on international crisis should be absorbed into larger theoretical concerns that focus on the objectives motivating the studies, as this appears to be one way to maintain definitional uniformity. Studies on crisis anticipation and crisis management should be viewed as efforts at war prevention. Studies on crisis management, which aim to reduce foreign policy fiascoes should be conceived in terms of foreign policy management. Findings of such studies can then be appraised in terms of the goals they seek.     

Empowering Students to Create and Claim Value through the Thomas–Kilmann Conflict Mode Instrument

In a world of problem‐solving lawyering, principled negotiation, and integrative bargaining, to describe a negotiation as “distributional” may strike some as heretical. Still, we disserve our students if we ignore distributional bargaining altogether. Unfortunately, many law students who are drawn to negotiation classes bring with them a fundamental discomfort with claiming value. Contrary to the stereotypes that attribute aggression and “sharp practices” to lawyers, many law students struggle to become more assertive. The Thomas–Kilmann Conflict Mode Instrument (TKI) is one tool that I have found can help raise students' awareness of, and comfort with, the reflexive responses to conflict that can impede their attempts to claim as well as create value in negotiation. The insights students gain from taking the TKI can be quickly put to use in the next negotiation role play. Although it may help students realize their dominant response to conflict, the TKI highlights that no single approach to negotiation is always best. Thus, the TKI can both encourage the reticent to claim more value in negotiation and suppress the seemingly insatiable appetites for value claiming that drive other students. When administering the TKI, I encourage students to learn at least four major lessons:

• 1 A negotiator has a choice in resolving the dilemma between value claiming and value creating. We are not just stuck with our reflexes.
• 2 Still, it is good to know what our reflexive response to conflict is likely to be so that we are more mindful of the choices as we make them.
• 3 Departing from reflexes requires energy: preparation, planning, mindfulness, and conscious effort.
• 4 Adaptability is desirable. A well‐integrated negotiator might move from one TKI “type” to another as a negotiation progresses.

In this article, I seek to give a very brief overview of the ways I have used the TKI to convey these lessons, increasing students' comfort with, and management of, value claiming. To this end, the article will describe the TKI, explain how I administer and debrief the students' encounter with it, and point out some potential pitfalls of this process.     

ASSESSING AND EXPLAINING MISPERCEPTIONS OF PEER DELINQUENCY*

Peer delinquency is a robust correlate of delinquent and criminal behavior. However, debate continues to surround the proper measurement of peer delinquency. Recent research suggests that some respondents are likely to misrepresent their peers’ involvement in delinquency when asked in survey questionnaires, drawing into question the traditional (i.e., perceptual) measurement of peer delinquency. Research also has shown that direct measures of peer delinquency (e.g., measures obtained via networking methods such as Add Health), as compared with perceptual measures, differentially correlate with key theoretical variables (e.g., respondent delinquency and respondent self‐control), raising the question of whether misperception of peer delinquency is systematic and can be predicted. Almost no research, however, has focused on this issue. This study, therefore, provides detailed information on respondents’ misperceptions of peer behavior and investigates whether individual characteristics, the amount of time spent with peers, and peer network properties predict these misperceptions. Findings indicated that 1) some individuals—to varying degrees—misperceived the delinquent behavior of their peers; 2) self‐control and self‐reported delinquency predicted misperception; 3) respondents occupying densely populated peer networks were less likely to misperceive their peers’ delinquent involvement; and 4) peers who occupy networks in which individuals spend a lot of time together were more likely to misperceive peer delinquency. Implications are discussed.     

Availability of target odor compounds from seized ecstasy tablets for canine detection

The aim of this study was to compare seized samples of 3,4-methylenedioxy-N-methylamphetamine (MDMA) pills, used to train law enforcement detection canine teams, to determine what differences exist in the chemical makeup and headspace odor and their effect on detectability. MDMA solutions were analyzed by liquid chromatography-mass spectrometry. Analysis of these samples showed a wide variance of MDMA (8-25%). Headspace SPME-GC/MS analysis showed that several compounds such as 3,4-methylenedioxyphenylacetone and 1-(3,4-methylenedioxyphenyl)-2-propanol are common among these MDMA samples regardless of starting compound and synthesis procedure. However, differences, such as the level of the various methylenedioxy starting compounds, were shown to affect the overall outcome of canine detection, indicating the need for more than one MDMA training aid. Combinations of compounds such as the primary odor piperonal in conjunction with a secondary compound such as MDP-2-OH or isosafrole are recommended to maximize detection of different illicit MDMA samples.