Detection of trace drugs of abuse in baby formula using solid‐phase microextraction direct analysis in real‐time mass spectrometry (SPME‐DART‐MS)

The intentional or unintentional adulteration of baby formula with drugs of abuse is one of the many increasingly complex samples forensic chemists may have to analyze. This sample type presents a challenge because of a complex matrix that can mask the detection of trace drug residues. To enable screening of baby formula for trace levels of drugs, the use of solid‐phase microextraction (SPME) coupled with direct analysis in real‐time mass spectrometry (DART‐MS) was investigated. A suite of five drugs was used as adulterants and spiked into baby formula. Samples were then extracted using SPME fibers which were analyzed by DART‐MS. Development of a proof‐of‐concept method was completed by investigating the effects of the DART gas stream temperature and the linear speed of the sample holder. Optimal values of 350°C and 0.2 mm/s were found. Once the method was established, representative responses and sensitivities for the five drugs were measured and found to be in the range of single ng/mL to hundreds ng/mL. Additional studies found that the presence of the baby formula matrix increased analyte signal (relative to methanolic solutions) by greater than 200%. Comparison of the SPME‐DART‐MS method to a traditional DART‐MS method for trace drug detection found at least a factor of 13 improvement in signal for the drugs investigated. This work demonstrates that SPME‐DART‐MS is a viable technique for the screening of complex matrices, such as baby formula, for trace drug residues and that development of a comprehensive method is warranted.     

Detection of Cutting Agents in Drug‐Positive Seized Exhibits within the United States

The following report summarizes a study performed on seized drug exhibits collected in two U.S. states to evaluate the presence and identification of cutting agents. Aliquots of seized drug materials from Kentucky (n = 200) and Vermont (n = 315) were prepared using a dilute‐and‐shoot procedure. Initial analysis was performed using gas chromatography–mass spectrometry (GC‐MS) followed by analysis using liquid chromatography quadrupole time‐of‐flight mass spectrometry (LC‐QTOF). Active compounds detected overall included caffeine (31.0%), quinine/quinidine (24.7%), levamisole (11.6%), acetaminophen, (8.2%) and procaine (8.2%). These compounds were found with several drugs of abuse, such as heroin, fentanyl, methamphetamine, and cocaine. This novel information about cutting agents used to dilute or alter drugs of abuse is important to criminal investigations and in the management of acute intoxications at health centers. However, common methodologies for analysis and standard reporting practices frequently do not include cutting agents, resulting in lacking or inadequate information regarding prevalence of these substances.     

Dying Quietly: English Suburbs and the Stiff Upper Lip

The English suburbs are dying. Years of austerity have slowly changed the landscape. Poverty is now common in the suburbs. Since 2014, life expectancy has been falling across most of England, especially in the suburbs. Now infant mortality rates are also rising year on year (unlike anywhere else in Europe). In hindsight it is not surprising that the majority of suburban English people voted Brexit, most noticeably in the Home Counties. Middle England is understandably angry. No more fortitude in the face of adversity and the hiding of emotions. The stiff up lip has slipped. Change is in the air.     

Direct‐to‐Consumer Genetic Testing,Gamete Donation,and the Law

Once thousands of dollars, direct‐to‐consumer (DTC) genetic testing has become affordable and readily accessible in recent years. The technology can reveal a wealth of information to consumers: health risks, ancestry composition, and connections to genetic matches through relative databases. However, the law has not yet regulated many aspects of this new technology. This article analyzes how the law should regulate DTC genetic testing within the context of gamete donation. It will argue that gamete donors’ privacy interests warrant state regulation of DTC genetic testing kits and their associated genetic relative databases. It will also explore how state regulation should balance the competing interests of gamete donors and of donor‐conceived individuals.     

Mais Médicos: Cuba's Medical Internationalism Programme in Brazil

In 2014, at the request of the Brazilian government and under the sponsorship of PAHO, the Cuban government sent 11,400 doctors to work in underserved areas. This article examines the origins and development of this programme, Mais Médicos. The significance of this programme is explored, as well as what it illustrates about south‐south cooperation as a whole.     

I Do,Thou Shalt Not: Religious Opposition to Same‐Sex Marriage in Britain

Proposals to legalise same‐sex marriage have provoked one of the most high‐profile and controversial political debates in recent years. The plans, being introduced by the governments at Westminster and Holyrood, have divided political and public opinion and have attracted widespread opposition from religious groups. However, while religious attitudes to homosexuality are shaped by theological concerns, religious justifications have been largely absent from the case against same‐sex marriage. Instead, religious groups have presented their arguments in secular terms centred on tradition, social utility, democratic values and the threat to religious rights and freedoms. This particular framing of the issue reflects processes of secularisation, a growing use of identity politics and the composition of religious groups themselves.     

Political competition and foreign policy power sharing

In this essay I examine the intersection of domestic and international politics in the formation and conduct of foreign policy. 1 develop a three‐actor model that allows us to specify the incentives for power sharing under different assumptions about the distribution of preferences and capabilities between a government, a domestic opposition, and a foreign state. The model generates several interesting hypotheses about the interaction of policy goals and the willingness of actors to share power. In particular, I show that under certain conditions there are important asymmetries whereby doves may be more willing to share power than hawks. Importantly, this willingness is endogenous to the model and comes from the alignment of preferences in the policy space, rather than from an a priori value for the democratization of foreign policy making. The model also suggests several hypotheses about the circumstances under which states have incentives to meddle in the foreign policy processes of other states.     

Estimating between‐ and within‐cluster covariate effects,with an application to models of international disputes

Students of international politics often use data in which the covariates vary both within and across units of observation. This is particularly true for dyadic data, which has come to dominate quantitative studies of international conflict, but is also a concern in any work involving a time‐series cross‐sectional component. Standard regression methods treat both types of covariates as equivalent with respect to their influence on the dependent variable, ignoring possible differences between cross‐dyad and within‐dyad effects. Here, I discuss the potential pitfalls of this approach, and show how between‐ and within‐dyad effects can be separated and estimated. I then illustrate the approach in the context of a logistic regression, using data on international disputes.