Postmortem Blood Concentrations of R‐ and S‐Enantiomers of Methadone and EDDP in Drug Users: Influence of Co‐Medication and P‐glycoprotein Genotype

Abstract: We investigated toxicological and pharmacogenetic factors that could influence methadone toxicity using postmortem samples. R‐ and S‐methadone were measured in femoral blood from 90 postmortem cases, mainly drug users. The R‐enantiomer concentrations significantly exceeded that of the S‐enantiomers (Wilcoxon’s test, p < 0.001). The samples were divided into four groups according to other drugs detected (methadone only, methadone and strong analgesics, methadone and benzodiazepines, or methadone and other drugs). There was no significant difference in any of the R‐methadone/total methadone ratios among the four groups. The median R/S ratio was 1.38, which tends to be higher than that reported for the plasma of living subjects. In addition, we investigated whether small nucleotide polymorphisms in the MDR1 gene that encode the drug transporter P‐glycoprotein were associated with the concentrations of R‐ and S‐methadone and its metabolite 2‐ethylidene‐1,5‐dimethyl‐3,3‐diphenylpyrrolidine. No significant association was detected.     

试论“后悔权”设立之法学证成

作为舶来事物,＂后悔权＂一经浮出水面,即遭受或赞或弹的命运。其中的质疑不无道理,但又有失偏颇。据此,厘清＂后悔权＂之真正意旨,区别相关权利,奠定对其讨论的正确基础实为必须且为必要。此外,＂后悔权＂作为一个货真价实的＂国际惯例＂,无理由将之拒之门外,但为避免＂水土不服＂的尴尬,其设立必须兼顾本土实际,即：一切从实际出发,设立中国特色的＂后悔权＂制度——＂有限后悔权＂制度。     

The Static-99R predicts sexual and violent recidivism for individuals with low intellectual functioning*

A current debate is whether actuarial risk assessment tools predict sexual recidivism in sexual offenders with intellectual disabilities (SOIDs). Since intellectual functioning exists on a spectrum, the present study examined the predictive validity of the Static-99R across the range of intellectual functioning. The sample was comprised of 454 adult sexual offenders assessed at an outpatient clinic and followed for an average of 10 years. Offenders in the extremely low/borderline group had higher scores on the Static-99R than other offenders, largely due to their score on the detachment subscale of the Static-99R, but did not have significantly higher recidivism rates. Calibration analyses suggested that the expected and observed recidivism rates did not differ significantly. Intellectual functioning did not add incremental validity to the Static-99R. Further, there was no interaction between intellectual functioning and actuarial risk score. The results suggested that the Static-99R can be used across the range of intellectual functioning, albeit somewhat more cautiously for those at the lowest and highest end of the intellectual functioning distribution.     

Protection gaps for civilian victims of political violence

This article begins by explaining why the United Nations' civilian protection agenda is particularly relevant and important for Africa and why the Responsibility to Protect (R2P) might be said to be an African norm export to the rest of the world. Next, it traces the reasons for peace operations' reluctance to use force. It then shows how the civilian protection agenda has tried to fill critical gaps in the existing normative architecture, with both R2P and the Protection of Civilians (POC) resulting from growing shame at the accumulating list of atrocities in which the international community stood by as passive onlookers, frustrations at the ‘constitutional’ constraints and normative inadequacies rather than indifference and apathy to the plight of civilian victims that produced the passivity, and a determination to reposition the United Nations system to be empowered and capacitated to be able to respond better on both the timeliness and effectiveness dimensions when confronted by repeat occurrences of similar tragedies. The fourth section discusses the merits of the R2P and POC norms in responding to the challenge of civilian protection. The final part notes that, despite these two valuable additions to the repertoire of the international community in dealing with atrocities perpetrated on civilians, there remain many gaps in the protection agenda, as shown in several recent cases.     

A study of stranger rapists from the English high security hospitals

Abstract

Heterogeneity hinders our understanding of sexual violence; but does this problem extend to stranger rape and, if so, would the construction of homogeneous subtypes advance our understanding of this crime and aid criminal investigations and clinical practice? To answer these questions, 41 stranger rapists from the English high security hospitals were examined using version 3 of the Massachusetts Treatment Centre rapist typology (MTC:R3) and multidimensional scaling (MDS). The MTC:R3 suggested that sexual desire and opportunism were the primary motivations for these men, but that proportionately more psychopaths were violent and sadistic. In accordance with previous research, the men experienced problematic childhoods and displayed high rates of criminality and psychiatric morbidity in adulthood. However, MDS found that rapist histories and offence behaviours generally divide into sexual and violent themes. These results have important implications for theory, criminal investigations and clinical practice.     

Digitizing Peircean semiotics to analyze students’ peer-review comments: classroom use of an application in open-source R

ABSTRACT

Statistical software applications are increasingly used to measure student engagement in the classroom. However, more work remains to be done to clarify how meaning is created and measured in classroom settings. With the growing use of technology in the classroom, students’ peer review has become a standard practice to improve students’ writing skills. This article examines the use of an open-source R software application based on Peirce’s sign theory to analyze students’ peer-review comments. Peer review is the assessment of student or professional work by others. The importance of open-source R as a platform lies in the fact that users can extend its code without having to ask permission. The results suggest a new approach, based on computational and social semiotics, to the assessment of students’ peer-review comments in higher education.     

Constructing patient–psychiatrist relations in psychiatric hospitals: the role of space and personal action

This essay investigates the role of space and personal action in the construction of patient–psychiatrist relations at psychiatric hospitals. In order to explore such a theme, the writings of R.D. Laing prove to be salutary. This is namely accredited to Laing's tenet that the staff and patients of a psychiatric hospital are institutionalised by both physical structures and personal action. A central approach taken in this essay is to explore Laing's theory through an inter-textual reading of Michel Foucault's Madness and Civilization (1967) and Erving Goffman's Asylums (1961).     

Against ‘creativity’: a ­philistine rant

The aspiration to be creative seems today to be more or less compulsory in an increasing number of areas of life. In psychological vocabularies, in economic life, in education and beyond, the values of creativity have taken on the force of a moral agenda. Yet creativity is a value which, though we may believe we choose it ourselves, may in fact make us complicit with what today might be seen as the most conservative of norms: compulsory individualism, compulsory ‘innovation’, compulsory per­formativity and productiveness, the compulsory valorization of the putatively new. This article suggests that, in order to escape the moralizing injunction to be creative, we need to cultivate a kind of ethical philistinism, albeit disaggregating such philistinism from the negativism of outright cynicism or fatuity. However, there is not much use in outlining an abstract model of philistinism. Instead, we take some ‘exemplars’ of a philistine attitude to creativity – Gilles Deleuze, F. R. Leavis, and Paul Cézanne – in order to show how such an ethos can be accomplished, on the one hand, with or without philosophy, and, on the other, with or without even the very idea of creativity itself, invoking instead the notions of ‘inventiveness’ and an ‘ethics of inertia’ as against creativity as such. The message should be that, rather than this or that theory, only exemplars – the bit-by-bit assembly of reminders – can help liberate us from the potentially moronic consequences of the doctrine of creativity.