Systematic review of randomised controlled trials:Probiotics for functional constipation

AIM:To systematically evaluate and update evidence on the efficacy and safety of probiotic supplementation for the treatment of constipation. METHODS:The MEDLINE,EMBASE,CINAHL,and Cochrane Library databases were searched in May 2009 for randomised controlled trials(RCTs)performed in paediatric or adult populations related to the study aim. RESULTS:We included five RCTs with a total of 377 subjects(194 in the experimental group and 183 in the control group).The participants were adults (three RCTs,n=266)and ...     

The Psilocin (4-hydroxy-N,N-dimethyltryptamine) and Bufotenine (5-hydroxy-N,N-dimethyltryptamine) Case: Ensuring the Correct Isomer has Been Identified

Psilocin (4-hydroxy-N,N-dimethyltryptamine, 4-HO-DMT) and bufotenine (5-hydroxy-N,N-dimethyltryptamine, 5-HO-DMT), which are both naturally occurring compounds, are classified as controlled substances in numerous countries due to their pharmacological activities and recreational usage. There are two other benzene ring regioisomers, 6-hydroxy-N,N-dimethyltryptamine (6-HO-DMT) and 7-hydroxy-N,N-dimethyltryptamine (7-HO-DMT), which are not classified by name as controlled substances, and which were synthesized for this current work. The four isomers were analyzed using routine methodologies employed by the Israel's Police Division of Identification and Forensic Science (DIFS) Laboratory, namely thin layer chromatography (TLC), Fourier transform infrared spectroscopy (FTIR), and gas chromatography mass spectroscopy (GC-MS). It was found possible to differentiate the four isomers. Forensic specimens that were suspected to be psilocybe mushrooms were examined, confirming that it is now possible to unequivocally identify the presence of psilocin and rule out the presence of its other isomers.     

On the concept of the “economic constitution” and the importance of Franz Böhm from the viewpoint of legal history

During its development, the concept of an economic constitution embraced varying elements. At the birth of the Federal Republic, these elements stood in sharp contrast to each other. After World War I Hugo Sinzheimer associated the concept with theGemeinwirtschaft (publicly controlled economy) as an expression of the organized economy of the Weimar Reichsverfassung. Franz Böhm deserves recognition for having cast the idea of competition into legal forms; thus he laid the foundation of our economic order and opened new horizons for the concept of economic constitution.     

宪法在司法审判中的适用性研究

自建国以来,最高人民法院没有明确拒绝宪法在司法审判中的可适用性,但在具体司法实践中,更倾向于在民事审判领域将宪法作为司法审判的法律依据,对刑事审判和行政审判中能否适用宪法采取回避态度。地方人民法院在司法审判中适用宪法的情况呈现多样化和复杂化趋势。地方人民法院在司法审判中援引宪法作为判案依据必须谨慎而行,尽量避免涉及宪法解释和违宪审查的事项。但对于援引宪法能够强化审判案件中法律依据的合理性和法律效力的,可予以保留。     

论民事诉讼简易程序的法理基础

民事诉讼简易程序作为迅速、廉价地解决民事简单案件的诉讼程序 ,得到越来越广泛的肯定和适用。设立民事诉讼简易程序 ,并非仅仅是为了提高法院的办案速度而采取的权宜之计 ,而是基于公民获得司法救济权、诉讼费用相当、司法资源的合理配置以及适时审判等诉讼法理的必然要求     

Drunk and dangerous: a randomised controlled trial of alcohol brief intervention for violent offenders

To assess the effectiveness of an alcohol brief intervention administered to violent offenders in a judicial (Magistrates’ court) setting, a randomised controlled trial was conducted. Participants (n = 269) were men aged 16–35 years, who resided within a 30-mile radius of Cardiff, UK, and who had been sentenced for a violent offence committed whilst intoxicated with alcohol. Recruitment occurred on-site. Participants were randomly allocated to receive an alcohol brief intervention (n = 135) or to a control group (n = 134). Objective measures comprised re-offending and injury rates. Self-reported outcome measures comprised Alcohol Use Disorders Identification Test (AUDIT); number of drinking days in the past 3 months; total weekly standard units of alcohol; and stage of change with respect to alcohol consumption (as measured by the Readiness to Change Questionnaire). Participants were followed up 3 months (n = 234; 87%) and 12 months (n = 202; 75.1%) after sentence. No significant between-group differences were observed in any of the alcohol measures or in re-offending. Injury was significantly less likely in offenders who had received the intervention (27.4%) than those who had not [39.6%; 95% confidence interval (CI) = −0.23, −0.009]. At 3-month follow-up, significantly more participants in the intervention group (31%; n = 37) than control group (16%; n = 18) demonstrated an increase in their readiness to change drinking behaviour (χ² = 8.56; df = 2; P = 0.014), but this did not persist at 12-month follow-up.

Applying the Consolidated Standards of Reporting Trials (CONSORT) to studies of mental health provision for juvenile offenders: a research note

The degree of reporting transparency in randomised controlled trials (RCTs) is an important factor when the validity of any results is being considered. The use of the Consolidated Standards of Reporting Trials (CONSORT) guidelines has improved the reporting standards of RCTs in many healthcare journals, but these guidelines have yet to be adopted universally. In this study, we applied the CONSORT Statement to RCTs identified from a systematic review of mental health provisions for juvenile offenders. We assessed the number of CONSORT items reported in each trial and investigated the extent of endorsement by journal editors. The findings showed that some items were fully endorsed (e.g., the aim of the study) whereas other items, such as sample size estimations, were not presented in any of the trials. A minority of journals supported the use of the CONSORT Statement in their journals’ instructions for authors. The overall reporting standard for this sample of trials was, therefore, mixed. Comparisons with trials conducted in other disciplines are discussed, and suggestions for improving reporting standards are presented.

Untimely Economies of Survival

This article takes the recent turn against hope in breast cancer activism as a point of entry into a broader examination of speculative economies of science that creatively imagine, materialize, and manage futures in the present. It argues that untimeliness – anticipatory, simultaneous, porous, and prognostic in its articulation – captures these alternate arrangements of life and action as they are mobilized in cancer research that hails healthy women as experimental subjects to participate in clinical studies.     

Improving evaluation of anti-crime programs: Summary of a National Research Council report★

This article summarizes a report of the National Research Council: Improving Evaluation of Anti-crime Programs. It is based on a workshop, held in September 2003, in which participants presented and discussed examples of evaluation-related studies that represent the methods and challenges associated with research at three levels: interventions directed toward individuals; interventions in neighborhoods, schools, prisons, or communities; and interventions at a broad policy level. The article, and the report on which it is based, is organized around five questions that require thoughtful analysis in the development of any evaluation plan: What questions should the evaluation address? When is it appropriate to conduct an impact evaluation? How should an impact evaluation be designed? How should the evaluation be implemented? What organizational infrastructure and procedures support high quality evaluation? The authors highlight major considerations in developing and implementing evaluation plans for criminal justice programs and make recommendations for improvement of government funded evaluation studies.