HPLC-MS/MS法检测大鼠体内氟胺酮及其代谢物动态分布规律

目的研究氟胺酮及其代谢物(去甲氟胺酮)在大鼠体内动态分布规律,为涉氟胺酮死亡案件法医学鉴定提供实验依据。方法将104只SD大鼠随机分为13组,1组作为空白对照组,其余12组,禁食12h,经腹腔注射0.09mg/kg氟胺酮后,分别在不同时间点(15min、30min、45min、60min、90min、120min、180min、240min、300min、360min、420min、480min)处死,立即取心血、心、肝、脾、肺、肾、脑,用高效液相色谱-三重四级杆质谱HPLC-MS/MS检测各组织中氟胺酮及代谢物去甲氟胺酮的浓度。结果氟胺酮经腹腔注射进入体内后,迅速分布于各组织,且在15min内达最高浓度。在480min内,氟胺酮和去甲氟胺酮在血液中均有分布,且含量均高于其他组织;其他组织中氟胺酮在肝、肾、脾中分布较多;去甲氟胺酮在肝、肾中分布较多。结论氟胺酮及去甲氟胺酮大鼠体内的动态分布规律可以为涉氟胺酮死亡案件提供数据支撑。     

Between idealism and reality: the unknown chapter of the Thessalonikian dockworkers in their struggle in the port of Haifa, 1933–1935

In the struggle of Jewish labor in the port of Haifa during the British Mandate, the Thessalonikian dockers played a major role. Until recently the story of their absorption was analyzed ‘from above’ with a functionalist-nationalist explanation. The Thessalonikians arrived equipped with professional skills, enthusiasm, and Zionist solidarity, which ostensibly was to be sufficient for their successful occupational integration at the waterfront. This article looks again on (1) the push–pull factors of migration, and (2) the professional and economic absorption in the waterfront of Haifa, but according to social history approach and ‘from below’, from which emerges a much more complex story. We note failures and successes to gain a foothold in the maritime labor market, the persistence involved, and the partial withdrawal from the struggle. The deepening chasm between national idealism and social reality brought an ongoing polemic between the Thessalonikian dockers and the Zionist elites of the interwar Yishuv, with both sides failing to bridge the gaps.     

The Outcome of Renegotiations between Institutionalized Public–Private Partnerships and Their Public Clients: Data on the Public–Private Partnerships of the German Federal Armed Forces

This study analyzes the renegotiations that take place between institutionalized public–private partnerships (PPPs) and their public clients drawing on survey data on the PPPs of the German Federal Armed Forces. Generally, both the party that initiates such renegotiations and the time at which renegotiations are launched determine the outcome of the PPP’s renegotiated remuneration. This effect is moderated by the degree of contract specificity and by a decrease in demand. Specifically, when the public client initiates the renegotiation of an incomplete contractual agreement due to a decrease in demand, it can successfully reduce the remuneration of the PPP.     

Public–Private Partnership (PPP) as an Interdependent Form (I-Form) Organization

As “public–private partnership” (PPP) is becoming a popular model among states, the debate concerning how to make it more successful is accelerating. Based on insights from contemporary organization theory (OT), the present article suggests that instead of taking PPP as “partnership” between private and public sector partners, it is rather more beneficial to construe it as inter-dependent form (I-Form) organization. Subsequently, it identifies three types of interdependencies, faced by PPP-based I-Form organizations, and furnishes a model—comprising of initial and external conditions, and interplay of internal factors—that could enable smooth functioning and performance of I-Form organization.     

Challenges for EU governance through Neighbourhood Policy and Eastern Partnership: the values/security nexus in EU–Belarus relations

Whereas the European Union (EU) has had some effect on political and economic reforms in the Ukraine and Moldova, it almost completely failed to impress the regime and population of Belarus. Despite growing consensus at the EU level that the Union's policies for Eastern Europe cannot succeed without Belarus, few attempts have been made to account for the failure of EU governance in Belarus. Having recalled the current legal and institutional set-up of EU–Belarus relations, this article introduces the notion of the ‘values/security nexus’ to explain the limited impact of EU governance in Belarus. It argues that the highly contradictory normative objectives in the Union's current Neighbourhood Policy towards Belarus effectively undermine the EU's credibility in the country: idealist values of ‘winning the hearts and minds’ of the Belarusian population increasingly collide with traditional realist goals of protecting EU interests and the stability of the Belarusian state. By way of conclusion, the article highlights the challenges facing the EU's new Eastern Partnership, including Belarus.     

Chemical fingerprinting of petrochemicals for arson investigations using two-dimensional gas chromatography - flame ionisation detection and multivariate analysis

Two-dimensional gas chromatography is a mature, yet underutilised, separation technique able to provide the high resolution and peak capacity required for the study of complex samples such as oils. This paper presents the development of a comprehensive two-dimensional gas chromatography method with flame ionisation detection to profile easily available ignitable liquids commonly found in arson cases. The use of 2D chromatograms to profile different potential ignitable liquids was also explored for classification purposes. The chemical fingerprints produced were visually different and allowed the distinction of all the petroleum products tested. How the chemical fingerprints of each fuel changed over time was also assessed. Each sample was subjected to weathering with aliquots (1 mL) being collected every half hour for a five-hour period. Principal component analysis of the resulting data was able to demonstrate the effect of weathering for all fuels tested and established that it was still possible to differentiate between the various petrochemicals even after weathering. The work demonstrates an optimised analytical method for petrochemical product analysis that provides forensic scientists with a robust, fast and sensitive technique that can be used to determine not only which ignitable liquid was used in a fire (even after the fact) but also provide information on the specific fuel used.     

The abiding voter: The lengthy horizon of retrospective evaluations

Although the theory of retrospective voting receives wide support in the literature on voting behaviour, less agreement exists on voters’ time horizon when assessing the government's performance – that is, whether voters are myopic. Previous studies on voter myopia tend to focus on aggregate-level measures of the economy, or use an experimental approach. Using panel data, this article offers the first investigation into voter myopia that uses individual-level evaluations of government performance in a representative survey at several points during the electoral cycle. The study focuses on The Netherlands, but it also provide tests of the generalisability and robustness of the findings, and a replication in the American context. The results indicate that voter satisfaction early in the government's term adds to explaining incumbent voting. Thus, rather than the myopic voter, evidence is found of the abiding voter – steady at her or his post, evaluating government performance over a long length of time.     

Lean models,complex realities: elite interactions in post-conflict democratisation at the local level

Abstract

This article argues that accounting for the complexity of interaction in post-conflict democracy promotion is important to understand how interactions influence post-conflict democratisation. Using the case of democracy promotion in Kosovo, the article uncovers two aspects in interaction processes where accounting for complexity is particularly useful: domestic goals and actor constellations. Taking into account the variety of domestic goals helps to understand how democratic reforms are subverted by domestic elites for the sake of their own domestic agenda. Disentangling the complexity of actor constellations demonstrates that interaction dynamics are shaped by the leverage and the number of international actors involved in the negotiation. The article draws on fine-grained local-level data from Kosovo to illustrate the argument.     

White pages: Israeli censorship of Palestinian textbooks in East Jerusalem

This study examined History textbooks taught in East Jerusalem. The political context of East Jerusalem and its education system manifests a continuous power struggle between the Palestinian National Authority and Israeli authorities, in this case, the Israeli Ministry of Education. Through analyzing the textbooks, this study speaks of the power dynamics and systems of political control manifested through the Israeli censorship. The aim of this paper is to present the intricate power relations of the education system in East Jerusalem as it is revealed in the censorship of textbooks. In analyzing the content censored in textbooks for elementary and high schools, three main censorship categories emerged: “erasing symbols,” “leaving out segments,” and “deleting the content of whole pages.” These are presented and analyzed within a political context in the study.