柴芍二至散治疗Graves病临床观察

目的 观察柴芍二至散治疗毒性弥漫性甲状腺肿（Graves病）的临床疗效及对谷胱甘肽过氧化物酶（glutathione peroxidase,GSH-Px）、丙二醛（malondialdehyde,MDA）的影响,探讨其治疗Graves病的作用机制。方法 将60例肝虚痰结型Graves病患者随机分为治疗组和对照组,每组各30例。对照组采用甲巯咪唑进行治疗,治疗组在对照组基础上加服柴芍二至散,两组疗程均为12周。比较两组中医证候疗效、甲状腺功能［游离三碘甲状腺原氨酸（free triiodothylamine,FT3）、游离甲状腺素（free thyroxine,FT4）、促甲状腺激素（thyroid stimulating hormone,TSH）］、血清促甲状腺受体抗体（thyrotropin receptor antibody,TRAb）、GSH-px、MDA水平。结果 与对照组比较,治疗组血清中FT3、FT4、TRAb水平显著降低（P＜0.05）,TSH水平显著升高（P＜0.05）;两组血清GSH-px、MDA水平均优于治疗前（P＜0.05）,治疗组改善更明显（P＜0.05）;治疗组中医证候疗效明显优于对照组（P＜0.05）。结论 柴芍二至散治疗Graves病疗效显著,其机制可能与改善GSH-px、MDA的表达,调节机体抗氧化水平有关。     

芪丹通脉片对急性心肌缺血犬血清NO和血浆ET水平的影响

目的：观察芪丹通脉片对急性心肌缺血犬血清一氧化氮（NO）和血浆内皮素（ET）水平的影响。方法：结扎冠状动脉左前降支复制犬急性心肌缺血模型，经十二指肠灌入实验药物，经颈外静脉插管至冠状静脉窦，测定结扎冠状动脉药前及用药后不同实验时间点的血清NO和血浆ET水平，实验结束后取缺血区心肌组织测定心肌组织NO和ET的含量。结果：与对照组比较，芪丹通脉片能升高血清和心肌NO水平，降低血浆和心肌ET水平，在芪丹通脉片高剂量组用药30min以后效果尤为明显（P＜0．05）。结论：促进NO产生和抑制ET合成，是芪丹通脉片抗心肌缺血性损伤的机制之一。     

化痰降气胶囊对慢性阻塞性肺疾病模型大鼠影像学的影响

目的:探讨慢性阻塞性肺疾病(COPD)模型大鼠及化痰降气胶囊治疗后影像学的变化.方法:采用气管内注入脂多糖加熏香烟复合刺激法复制大鼠COPD模型.治疗组4周后给药,6周后各组摄片.结果:呼吸频率各组相比,差异有显著性(P<0.05或P<0.01);各组横膈前肋、横膈后肋、肋间隙积分比较,差异有显著性(P<0.01);横膈前肋积分,模型组与治疗组相比,差异有显著性(P<0.05).结论:COPD大鼠有明显的肺气肿影像学表现,化痰降气胶囊对COPD大鼠的影像学有较为明显的改善作用.     

关于完善我国医疗事故责任等级的建议简

我国现行的《医疗事故技术鉴定暂行办法》规定了医疗事故中医疗过失行为的责任程度分为：完全责任、主要责任、次要责任、轻微责任。该办法用这四种责任程度来判定医疗过失行为的责任程度存在明显的缺陷,缺少了一个同等责任程度的规定。为了今后便于司法实践的操作,公平合理地维护医患双方的权益,应该增加同等责任程度的规定,来完善我国医疗事故技术鉴定相关立法。     

论失踪损害赔偿之诉的法律适用——以马航客机失踪事件切入

自然人的失踪通常都会给其近亲属造成严重的精神损害和一定的财产损害,依据我国法律现有规定及其解释,在失踪是因可归责于他人的事由所致时,失踪者近亲属应独立享有对相关责任人的损害赔偿请求权。肯定此类损害赔偿请求权,不仅符合分配正义原则,而且能更好地实现权益保护与行为自由的平衡。在单纯的失踪损害赔偿之诉中,失踪者近亲属可以请求赔偿精神损害、寻亲费用和扶养费损失等,在失踪者已被宣告死亡时,还可请求死亡赔偿金。     

Religious Radicalization and Lone‐Actor Terrorism: A Matter for Psychiatry?

This article discusses the place of the psychiatric field in the ongoing phenomenon of religious radicalization. First, the article provides an overview of the existing literature on lone‐actor terrorists and the link with mental illness. Current research is focusing increasingly on lone‐actor terrorists. This is the most recent and rising development on the global terrorism scene. The literature is currently developing a more precise and informed definition of lone‐actor terrorism. The article then describes and discusses the case study of a mentally ill patient arrested following his assault on a military serviceman on the grounds of religious radicalization. The patient, diagnosed with schizophrenia, is taken as an example of the specific case of religious radicalization in patients with schizophrenia. Finally, the article discusses the curative and preventive roles that can be played by psychiatrists and other professionals who are in contact with these types of patients.     

Complex Congenital Heart Malformation Including Transposition of the Great Vessels,Presenting as Sudden Unexplained Infant Death

Transposition of the great vessels (TGV) is a common congenital heart defect that is difficult to diagnose before birth. Antenatal diagnosis is associated with increased survival. Unusual features such as anomalous pulmonary artery origin may delay cyanosis, decreasing clinical suspicion. A three‐week old female infant who had never been cyanotic presented for forensic autopsy due to onset of unresponsiveness at home. History included risk factors for TGV and signs of heart enlargement that were not recognized during life. Cardiac pathology consultation identified D‐type TGV with additional rare anomalies. TGV may present as sudden unexplained infant death (SUID) for forensic autopsy if variant features prevent development of cyanosis. Cardiac pathology consultation is helpful in clarifying these features.     

Referrals to a mental health criminal justice Liaison and diversion team in the North East of England

There is growing interest in the health correlates of people detained in police custody, and a number of innovations have been introduced to try to meet the complex needs of detainees. The implementation of Criminal Justice Liaison and Diversion (CJL&D) Services commissioned by the Department of Health in England is a substantial part of this investment. In this paper, we describe data from 858 detainees who were referred to the CJL&D service of a busy metropolitan police station in the North East of England. The detainees referred to the service had complex mental health needs, substance misuse and a range of vulnerabilities requiring specific intervention. The effective operation of these teams and how they interface with health and criminal justice systems also depend upon a number of systematic issues that emanate both from within the teams, and from external policy drivers.     

Health characteristics of older police custody detainees in London,UK

The number of older adults involved in the criminal justice system is rising. Little is known about the state of health in older people who are arrested. This study compared characteristics and health care needs of older police custody detainees with their younger counterparts. The health characteristics of 57 police detainees aged over 50 were compared with 543 younger detainees. Older detainees had significantly higher rates of physical illness and risk of alcohol withdrawal. Although there were equivalent rates of mental disorder and drug taking compared with younger detainees, a higher proportion had presentations consistent with cognitive impairment due to possible dementing processes. Over 80% of older detainees were recommended to have a health assessment in police stations based on their presentation. Police detainees over 50 should be considered to have a health assessment as routine procedure. Further investigation should also be conducted into cognitive impairment in this group.     

Using the National Diabetes Audit to improve the care of diabetes in secure hospital in-patient settings in the UK

To examine the ability of two forensic units, one high secure and one medium secure, to meet the NICE (National Institute for Health and Care Excellence) standards of care for diabetes. We applied the National Diabetes Audit programme, which uses as standards the NICE guidelines, to assess the quality of care provided for patients in two forensic units. Of the 500 patients, 200 in high secure and 300 in medium secure, 88 (17.6%) had type 2 diabetes. None had Type 1 diabetes. Of those with Type 2 diabetes, the care of 74 (84%) met all 8 NICE recommended standards. Glucose levels were lower in the medium/low secure unit compared to the higher security environment. Whilst achievement of process-based outcomes was higher than those reported nationally, achieving clinical outcomes was more challenging. High-quality diabetic care can be provided for patients in forensic units. Benchmarking physical health outcomes against national criteria in mental health inpatients is a potential method of improving outcomes.