Correlative Factors for Organic Psychotic Symptoms in Patients Following Traumatic Brain Injury

Objective To investigate the correlative factors for organic psychotic symptoms following trau matic brain injury （TBI）. Methods In the current study, 391 subjects who had undergone forensic iden tification of the organic mental disorders due to TBI were included, both the demographic and posttrau matic information collected. The relevant data were statistically analyzed in those confirmed as organic psychotic syndrome according to Chinese Classification of Mental Disorders 3rd version （CCMD3）. Re suits Fiftytwo subjects （13.3%） were identified as organic psychotic symptoms. The chisquare test showed that the detectable organic psychotic symptoms were associated with the marriage status, damage nature, injury severity and treatment, and the multivariate logistic regression analysis revealed good fitness of treatment and injury severity with the regression model （OR=0.044, 95% CI： 0.0170.114; OR=2.145, 95% CI： 1.201-3.832, respectively）. Conclusion The risks of organic psychotic symptoms following TBI can be involved in the alternative of craniotomy for the cases with trauma and moderate brain injury.     

Wilson病认知功能障碍与肠道菌群的相关性研究

目的 探讨Wilson病(Wilson’s disease, WD)认知功能障碍与肠道菌群的关系,以期为临床治疗WD合并认知功能障碍提供理论基础。方法 选取38例WD伴认知功能障碍的患者作为观察组,同时选取32例WD不伴认知功能障碍的患者为对照组,取大便样品进行16S rRNA基因测序技术分析,通过检测两组患者肠道菌群的组成及其丰度,探讨两者之间的相关性。结果 在门水平上,与对照组比较,观察组拟杆菌门和放线菌门丰度明显升高(P<0.05),厚壁菌门和变形菌门丰度明显降低(P<0.05);在科水平上,与对照组比较,观察组双歧杆菌科、紫单胞菌科、拟杆菌科、产碱杆菌科、理研菌科、乳酸菌科、韦荣氏球菌科丰度明显升高(P<0.05),梭菌科、科里杆菌科、未分类拟杆菌、肠杆菌科、毛螺菌科、乳球菌科、普氏菌科、链球菌科丰度明显降低(P<0.05);在属水平上,与对照组比较,观察组乳酸菌属、小杆菌属、乳球菌属、柯林斯氏菌属、另枝菌属、拟杆菌属、双歧杆菌属、帕拉斯氏菌属丰度明显升高(P<0.05),直肠真杆菌属、布劳特氏菌属、克雷伯氏菌属、栖粪杆菌属、普雷沃氏菌属、链球菌属...     

肝豆汤调控NLRP3炎症小体抑制Wilson病模型神经炎症的机制研究

目的 通过观察肝豆汤对Nod样受体家族含pyrin结构域蛋白3(Nod-like receptor family, pyrin domain-containing protein 3,NLRP3)炎症小体的调控作用,探究其抑制Wilson病(Wilson’s disease, WD)模型神经细胞炎症损伤的机制。方法 体外实验中,采用CuCl₂诱导小胶质细胞(BV-2细胞)复制WD神经细胞损伤模型,并将BV-2细胞与海马细胞(HT-22细胞)条件培养,给予不同浓度肝豆汤含药血清。CCK-8法检测BV-2细胞及HT-22细胞活力,酶联免疫吸附法测定炎症因子水平,细胞化学法检测HT-22细胞乳酸脱氢酶(lactate dehydrogenase, LDH)漏出水平及氧化应激水平,Western blot法检测NLRP3炎症小体相关蛋白表达水平。体内实验中,以TX小鼠为模型组,并以DL小鼠为正常组,肝豆汤组给予TX小鼠肝豆汤灌胃4周。采用Barnes迷宫、旷场实验、高架十字实验观察小鼠行为,苏木精—伊红染色法观察小鼠海马组织的损伤程度,Western blot法检测NLR...     

A rare case of sudden death due to IgG4-related giant coronary artery aneurysms

Immunoglobulin G4-related disease (IgG4-RD) is a fibro-inflammatory condition that can affect many organs, either simultaneously or metachronously. In recent years, IgG4-related vascular complications of larger arteries such as the aorta and iliac arteries have been increasingly identified. Among vascular complications, coronary artery involvement in the forms of either periarteritis or coronary artery aneurysms (CAAs) has also been reported; however, are very rare in comparison. This case report presents a rare case of a sudden death due to occlusive thrombosis of IgG4-related giant CAAs measuring up to 10 cm in diameter, demonstrates their possible clinical progression, and shows how they can distort normal anatomy which may then pose challenges in the interpretation of postmortem-computed tomography scans. It also briefly discusses the diagnosis of IgG4-RD in arteries, both clinically and in the postmortem setting.     

外伤性硬脑膜下积液者90项症状自评量表评分分析

目的探讨外伤性硬脑膜下积液者的90项症状自评量表(Symptom Check List-90,SCL-90)分值变化的影响因素。方法选取皖南医学院司法鉴定中心2007—2018年受理的142例外伤性硬脑膜下积液的被鉴定人进行SCL-90测试,分析测得SCL-90得分与全国常模的差异,以及性别、年龄、文化程度、积液范围及部位对SCL-90分值的影响。结果外伤性硬脑膜下积液SCL-90的躯体化、人际敏感、抑郁、焦虑、敌对、恐怖、偏执、精神病性因子分值及总均分与全国常模比较,差异有统计学意义(P<0.05),男女性之间抑郁和敌对因子分值差异有统计学意义(P<0.05),不同年龄段间强迫、焦虑、恐怖因子分值及总均分差异有统计学意义(P<0.05),不同受教育程度人群中敌对、偏执和精神病性因子分值差异有统计学意义(P<0.05),单部位、双部位与多部位间抑郁、焦虑、敌对、恐怖因子分值及总均分差异有统计学意义(P<0.05),左脑区、双脑区与右脑区相比躯体化、抑郁、焦虑因子分值及总均分差异有统计学意义(P<0.05)。结论外伤性硬脑膜下积液可引起一定的精神心理变化,该变化与蛛网膜破裂的原发伤以及硬脑膜下积液范围和部位相关,进行精神心理症状评估时应注意上述因素的影响。     

传染病防治失职罪的适用困境与刑法应对

正在经历的新冠肺炎疫情使我们更加深刻地认识到传染病防治渎职行为的严重危害.但是,刑法第409条对传染病防治失职罪的立法规定,明显存在主体范围狭窄、行为方式单一、入罪门槛过高、刑罚配置失衡等问题.为了提高传染病防治渎职犯罪的治理效能,应当及时采取扩大主体范围、增列行为方式、降低入罪门槛、科学配置刑罚等措施,提高刑法第409条罪刑规范在传染病防治渎职犯罪治理中的能力和水平.     

氯喹类药物在新型冠状病毒肺炎治疗中的试用及其法医毒理学研究进展

氯喹类药物是一类历史悠久的处方药,临床常用于抗疟疾及结缔组织病的治疗。2019年12月以来,在我国各地和世界多国发生了由2019新型冠状病毒(2019 novel coronavirus,2019-nCoV)引起的新型冠状病毒肺炎(corona virus disease 2019,COVID-19)疫情。由于缺乏针对COVID-19的药物,导致该病迅速蔓延且死亡率较高,因此亟待快速筛选抗2019-nCoV的特效药物,已批准使用的抗疟药磷酸氯喹被证实具有抗2019-nCoV的作用,并被纳入诊疗指南。但对磷酸氯喹引起急性中毒甚至死亡的风险意识也应同时加强,当前临床推荐剂量较以往治疗疟疾用药剂量偏大、疗程偏长,多地已要求临床密切监测不良反应。本文从法医学的角度,对氯喹类药物的药理作用、中毒与毒理作用机制、体内代谢与分布及法医学鉴定要点进行综述,以期为法医学实践及临床工作提供帮助。     

Refugees Who Have Experienced Extreme Cruelty: A Qualitative Study of Mental Health and Wellbeing after Being Granted Leave to Remain in the UK

Abstract

This study explores how vulnerable refugees’ experiences in the first year after being granted leave to remain in the UK impact on mental health and wellbeing. Nine semi-structured interviews were conducted with refugee survivors of extreme cruelty. Data were analyzed using thematic analysis with a narrative influence. Reported challenges included requirements to organize housing, finances and welfare benefits rapidly. Most respondents reported low mood, worry, exacerbated PTSD symptoms, physical ailments and isolation, but valued stable housing, meaningful activities, emotional support and service provider sensitivity in managing this transition. Policy and service recommendations are made, to assist integration and improve wellbeing.     

Rethinking the Interface between Mental Illness,Criminal Justice and Academia

Punishment and treatment don’t occur within a vacuum. Responses in the justice system affect the mental health system, hospitals, clinics, and the welfare system. These systems are inextricably bound to each other. This paper, drawn from the 2009 Academy of Criminal Justice Sciences (ACJS) Presidential Address, discusses issues regarding the criminalization of mental illness, fiscal crises, and three deinstitutionalization movements. Particular attention is given to the role of academia in reshaping the criminal justice system during the current fiscal crisis.     

欧盟食品安全风险评估制度的基本原则之评析

以欧盟《统一食品安全法》和专门负责食品安全风险评估的欧盟食品安全管理局的相关指引以及其他与欧盟食品安全风险监管有关的政策为主要考察对象,可以发现欧盟食品安全风险评估制度的基本原则有四项,即科学上的卓越性原则、独立性原则、透明性原则和公众协商性原则。通过评析这些基本原则的主要含义、之所以成为基本原则的原因以及这些基本原则得以实现的具体机制,可以发现它们已经不是停留在纸面上的原则,这对我国食品安全风险评估制度的完善具有重要启发。