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Barrot C Simili C Sánchez C Brandt-Casadevall C González-Martín A Xifró A Ortega M Huguet E Corbella J Gené M 《Journal of forensic sciences》2007,52(2):504-506
Population: Amerindian populations: Huastecos (n=97), Otomies de la Sierra (n=41), Otomies del Valle (n=40), and Tepehuas (n=13). 相似文献
324.
Irwin JA Edson SM Loreille O Just RS Barritt SM Lee DA Holland TD Parsons TJ Leney MD 《Journal of forensic sciences》2007,52(5):1115-1118
This report describes the genetic identification of James "Earthquake McGoon" McGovern, a WWII fighter ace who perished in Laos while providing supplies to French troops during the French Indochina war. Because reference samples were unavailable for all of the potential casualties, testing of the entire mitochondrial genome, autosomal STRs and Y-chromosomal STRs was performed to increase the genetic information available for analysis. Kinship analyses performed on the evidentiary data and numerous indirect family references for McGovern excluded other possible casualties and definitively established McGovern's identity. This particular case demonstrates the practical utility of novel research technologies and aggressive genetic typing protocols in the identification of aged, degraded remains. 相似文献
325.
Leclair B Shaler R Carmody GR Eliason K Hendrickson BC Judkins T Norton MJ Sears C Scholl T 《Journal of forensic sciences》2007,52(4):806-819
Victim identification initiatives undertaken in the wake of Mass Fatality Incidents (MFIs) where high-body fragmentation has been sustained are often dependent on DNA typing technologies to complete their mandate. The success of these endeavors is linked to the choice of DNA typing methods and the bioinformatic tools required to make the necessary associations. Several bioinformatic tools were developed to assist with the identification of the victims of the World Trade Center attacks, one of the most complex incidents to date. This report describes one of these tools, the Mass Disaster Kinship Analysis Program (MDKAP), a pair-wise comparison software designed to handle large numbers of complete or partial Short Tandem Repeats (STR) genotypes, and infer identity of, or biological relationships between tested samples. The software performs all functions required to take full advantage of the information content of processed genotypic data sets from large-scale MFIs, including the collapse of victims data sets, remains re-association, virtual genotype generation through gap-filling, parentage trio searching, and a consistency check of reported/inferred biological relationships within families. Although very few WTC victims were genetically related, the software can detect parentage trios from within a victim's genotype data set through a nontriangulated approach that screens all possible parentage trios. All software-inferred relationships from WTC data were confirmed by independent statistical analysis. With a 13 STR loci complement, a fortuitous parentage trio (FPT) involving nonrelated individuals was detected. Additional STR loci would be required to reduce the risk of an FPT going undetected in large-scale MFIs involving related individuals among the victims. Kinship analysis has proven successful in this incident but its continued success in larger scale MFIs is contingent on the use of a sufficient number of STR loci to reduce the risk of undetected FPTs, the use of mtDNA and Y-STRs to confirm parentage and of bioinformatics that can support large-scale comparative genotyping schemes capable of detecting parentage trios from within a group of related victims. 相似文献
326.
[摘要]目的 观察醒脑静治疗急性丘脑出血的临床疗效。方法 将103例急性丘脑出血患者随机分为治疗组和对照组,两者均按CT分为3型,治疗组在对照组常规治疗基础上加用醒脑静治疗,观察两组各型丘脑出血治疗前后临床神经功能缺损程度评分变化,意识障碍转清及体温恢复情况。结果 与治疗前相比,治疗后两组Ⅰ型和Ⅱ型患者临床神经功能缺损程度评分比较显著降低(P<0.01),治疗组Ⅰ型、Ⅱ型患者评分显著低于对照组(Ⅰ型、Ⅱ型),差异有统计学意义(P<0.05)。与对照组相比,治疗组意识障碍患者神志转清时间明显缩短(P<0.05),发热患者平均体温升高幅度降低,体温恢复正常时间明显缩短(P<0.05)。结论 醒脑静对急性丘脑出血患者出现的意识障碍、发热及神经功能缺损等有明显治疗效果,能提高急性丘脑出血患者治愈率,降低致残率。 相似文献