超高效液相色谱-四级杆飞行时间串联质谱快速分析复方守宫散化学成分及血中移行成分

目的 采用超高效液相色谱-四级杆飞行时间质谱(ultra-performance liquid chromatogra-phy/quadrupole time-of-flight-tandem mass spectrometry,UPLC-Q-TOF/MS)对复方守宫散中化学成分及其血中移行成分进行定性分析,为该制剂的...     

灸刺督脉治疗气虚血瘀型缺血性脑卒中临床观察

目的 观察评价灸刺督脉疗法治疗气虚血瘀型缺血性脑卒中的临床疗效。方法 将气虚血瘀型缺血性脑卒中患者41例,随机分为对照组（20例）和治疗组（21例）。两组均予以基础病管理,对照组采用脑卒中气虚血瘀型常规针刺治疗,取穴为顶颞前后斜线、极泉、尺泽、内关、委中、足三里、三阴交、气海、血海;治疗组在常规针刺治疗基础上加用灸刺督脉疗法,取通督七穴（水沟、神庭、百会、风府、大椎、命门、腰阳关）,其中百会艾灸,大椎刺络,其余腧穴予以针刺治疗。治疗周期为14 d。疗程结束后以美国国立卫生研究院卒中量表（National Institute of Health stoke scale,NIHSS）及改良Rankin量表（modified Rankin scale,MRS）评分结果评价两组的临床疗效。结果 两组患者治疗后NIHSS及MRS评分均较治疗前显著降低（P<0.05）,治疗组NIHSS及MRS评分差值与对照组比较,差异均有统计学意义（P<0.05）。两组临床疗效分布比较,差异有统计学意义（P<0.05）。结论 灸刺督脉疗法治疗气虚血瘀型缺血性脑卒中临床疗效确切,优于常规针刺治疗。     

健脾活血方治疗肝豆状核变性并发脾功能亢进脾切除后血瘀证临床研究

目的 观察肝豆状核变性并发脾功能亢进脾切除后血瘀证形成情况及健脾活血法的临床疗效。方法 从脾功能亢进脾切除患者中选取术后发生血瘀证的患者,将其随机分为观察组和对照组。观察组予以术后健脾活血中药干预,对照组予以术后常规治疗。分别观察两组术后血瘀证、门静脉系统血栓(portal vein system thrombosis, PVST)发生率及其动态变化,并进一步观察血瘀证形成对术后肝功能恢复的影响。结果 271例术后脾功能亢进脾切除患者中,术后3 d共有223例(82.29%)出现血瘀证,对照组111例,观察组112例。术后7、14、21 d时观察组血瘀证发生率以及术后4、7、14 d时观察组PVST发生率显著低于对照组(P<0.05)。术后14 d开始两组血瘀证和PVST发生率逐渐下降;术后21、28 d两组血瘀证和PVST发生率的差异无统计学意义(P>0.05)。术后1 d两组肝功能指标均显著升高;术后3 d,两组血清丙氨酸转移酶(alanine transaminase, ALT)、天冬氨酸转移酶(aspartate transaminase, AST)活性,血清间接胆...     

一起美容医疗机构越级开展美容项目投诉事件的分析与思考

随着人们永葆青春和美貌欲望的增强和医疗美容技术的发展,医疗美容行业日益火爆,同时医疗美容监督管理发现的违法医疗美容行为也越来越多。通过对一起医疗美容机构越级开展美容手术投诉处理事件,对越级开展美容项目是否为超范围执业提出见解,同时对规范医疗美容活动提出建议和思考。     

旋毛虫IFN-γ诱导的溶酶体硫醇还原酶对大鼠外周血单个核细胞功能的影响

为了研究旋毛虫(Trichinella spiralis)IFN-γ诱导的溶酶体硫醇还原酶(GILT)对体外大鼠外周血单个核细胞(PBMCs)免疫功能的影响,将不同质量浓度的重组蛋白TsGILT(rTsGILT)与大鼠PBMCs体外共孵育后,用间接免疫荧光技术检测该蛋白与细胞之间的结合情况,并测定其对细胞增殖、迁移、凋亡、吞噬和NO分泌的影响。结果表明:rTsGILT可与大鼠PBMCs结合,可显著促进大鼠PBMCs的增殖、迁移、吞噬和NO的分泌(P<0.01),并呈现一定剂量依赖性;10、20μg/m L的rTsGILT对大鼠PBMCs的凋亡没有影响,40和80μg/m L的rTsGILT均能显著促进大鼠PBMCs的凋亡(P<0.001)。综上所述,旋毛虫GILT能通过多种途径影响宿主PBMCs发挥免疫作用,对宿主的免疫应答具有一定的促进作用。     

从条块到界面:基层政府“放管服”改革的内在逻辑——基于江苏省徐霞客镇的案例研究

中国的政府治理受制于央地关系和国家(政府)与社会关系的双重约束,这使得条块结构难以适应,在治理中带来了专业化分工与行政性协同、分散式服务与一体化需求、碎片化问题与整体性治理三对矛盾。为了破解矛盾、平衡双重关系,需要重塑治理结构。研究发现,基层政府通过打造信息界面、组织界面、服务界面、执法界面,为部门间、政府与公民的互动提供平台,实现以公民为中心的界面治理,用界面来弥补条块失灵。我们需要基于多重约束关系来设计相适应的治理结构,该观点是对威廉姆森基于交易成本选择治理结构的一种补充。     

Determining security level in forensic psychiatry: a tug of war between the DUNDRUM toolkit and the HoNOS-Secure

ABSTRACT

Criteria to determine in which level of security forensic patients should receive treatment are currently non-existent in Belgium. Research regarding the assessment of security level is minimal, and limited instruments are available. This study investigated the instruments that measure the need for security level: DUNDRUM-1 and the HoNOS-Secure. The psychometric properties of the DUNDRUM-1, DUNDRUM-2 and the HoNOS-Secure were investigated.

A random selection was made of 100 male forensic patients in prison. The DUNDRUM-1, DUNDRUM-2 and the HoNOS-Secure were scored retrospectively. A subsample of the files was rated by four researchers (n?=?38). Comparisons were made with the security level as decided by the court.

The DUNDRUM-1 achieved excellent inter-rater reliability, and the HoNOS-Secure and DUNDRUM-2 got a moderate score. The internal consistency was highest for DUNDRUM-1 followed by the HoNOS-Secure and was low for the DUNDRUM-2. Both the DUNDRUM-1 and the HoNOS-Secure predicted allocations by the court to high security.

The DUNDRUM-1 outperforms the HoNOS-Secure on psychometric properties and provides clear instructions with regard to the assessment of the security level. Training seems to be important for scoring the DUNDRUM-1. The current study provided more evidence for the applicability of the DUNDRUM-1 in Belgian settings with regard to determining the need for security.     

恒河猴ABO血型的研究

本文应用A型、B型、AB型血清，及抗－A与抗－B单克隆抗体对113只猕猴的ABO血型进行了测试。结果表明：在恒河猴（Macacamulatta）红细胞表面及血清中均未证明有类人凝集原和凝集素存在。但可根据其唾液中类人ABH型物质存在的情况判定该动物的类人血型。本实验检出的血型表型频率分别为：A型17．70％；B型52.21％；AB型20.36％；O型9.73％。该结果与国外报道的血型分布频率有差异。     

An emerging theory of the effect of economic contraction on alcohol abuse in the United States

Recent research in the United States describing the association between adverse economic experiences and the risk of clinically significant alcohol abuse is reviewed. A theory of how economic contraction affects the incidence of alcohol abuse is offered. Implications of the theory for economic policy and the provision of services are discussed.     

益气活血方对气虚血瘀证脑缺血再灌注损伤大鼠Fas、FasL蛋白表达的影响

目的：探讨益气活血方对气虚血瘀证局灶性脑缺血再灌注损伤大鼠Fas、FasL蛋白表达的影响。方法：采用气虚血瘀证局灶性脑缺血再灌注损伤大鼠模型，用线栓法阻塞大鼠大脑中动脉复制局部脑缺血再灌注模型，缺血2h后再灌注l，3，7d。用免疫组化染色法分别检测缺血皮质Fas、FasL蛋白表达。结果：与模型组比较。益气活血方组Fas、FasL蛋白表达显降低。结论：益气活血方可能通过抑制Fas、FasL蛋白表达，减轻气虚血瘀证局灶性脑缺血再灌注损伤。