We present results of our study on the stability of 4-chloromethcathinone (4-CMC) in authentic postmortem peripheral blood and vitreous humor samples. The stability of 4-CMC was determined in postmortem blood samples (for a period of 90 days) and vitreous humor (30 days) at three different temperatures: −15°C, +4°C, and + 23°C. The analyses were carried out using ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry (UHPLC-QqQ-MS/MS). In both materials, the lowest 4-CMC stability was demonstrated at room temperature. The blood samples stored in a freezer (−15°C) showed stability for the entire study period (90 days), while in the case of the vitreous humor sample stored at the same temperature the concentration of the substance decreased by 53% after 30 days. The study carried out in authentic postmortem blood and vitreous humor samples confirms the previous reports of 4-CMC instability in biological material. Authors suggest that the biological material should be stored frozen until analyses are carried out as soon as possible after collection of the material. 相似文献
Why do some peace agreements end armed conflicts whereas others do not? Previous studies have primarily focused on the relation between warring parties and the provisions included in peace agreements. Prominent mediators, however, have emphasised the importance of stakeholders at various levels for the outcome of peace agreements. To match the experience of these negotiators we apply a level-of-analysis approach to examine the contextual circumstances under which peace agreements are concluded. While prominent within the causes of war literature, level-of-analysis approaches are surprisingly scant in research about conflict resolution. This article compares two Sudanese Peace Agreements: the Comprehensive Peace Agreement (2005) that ended the North–South war and led to the independence of South Sudan, and the Darfur Peace Agreement (2006) which failed to end fighting in Darfur. We find that factors at the local, national and international level explain the different outcomes of the two agreements. Hence, the two case studies illustrate the merit of employing a level-of-analysis approach to study the outcome of peace agreements. The main contribution of this article is that it presents a new theoretical framework to understand why some peace agreements terminate armed conflict whereas others do not. 相似文献
Background: Alcohol-related rape among university students is clearly a major concern. However, there have been no large-scale surveys of the prevalence of this offence among university students in the UK. The aim of the current paper is to investigate the prevalence and characteristics of alcohol-related rape among university students in seven universities in Wales.
Methods: All universities in Wales were approached to take part in the research. Eight of the nine universities agreed to take part and seven universities emailed their students as planned. On the launch date, emails were sent by the universities to all students requesting that they take part in the survey. The email contained a link to a questionnaire covering a range of topics including: demographics, lifestyle factors, and substance misuse.
Results: In total, 7,846 students submitted a questionnaire. Overall, just under six per cent of females reported being the victim of alcohol-related rape while at university compared with one per cent of males. Sexual orientation was significantly correlated with alcohol-related rape, with three per cent of heterosexuals reported being the victim of alcohol-related rape, compared with eight per cent of lesbians or gays. Students who drank alcohol frequently and those involved in binge drinking were also significantly more likely to report the offence.
Conclusions: The government and universities should play a more direct role to ensure that actions are taken to deter, prevent, and treat the consequences of these largely unreported offences. 相似文献
While much research focuses on the causes and consequences of direct democracy and regime legitimacy, little attention has been paid to the potential relationship between them. In an attempt to fill this void, this paper focuses on the legal provisions for direct democracy and its use. The key argument is that possibilities for the public’s direct involvement reflect high importance given to citizens, openness of the regime towards different modes of decision-making, and ways to avoid unpopular institutions. Consequently, citizens are likely to accept and support the regime, improving or maintaining its legitimacy. The cross-national analysis includes 38 European countries ranging from transition countries to established democracies. It uses bivariate statistical analysis and country-level data collected from legislation, secondary sources, and aggregate surveys. 相似文献