大鼠颅骨材料力学和骨质参数的增龄性变化

目的 通过检测大鼠颅骨材料力学和骨质参数,探讨二者关系及其与年龄的相关性.方法 48只健康雄性SD大鼠按年龄分为2、4、6、8、17、26、52和104周龄组,每组6只.利用KDⅡ-0.2型微机控制电子万能试验机压缩右侧颅盖骨检测其材料力学参数(极限载荷、压缩强度、压缩模量),之后分离颅骨骨片进行Micro-CT系统扫...     

更腐倡廉制度建设的几点思考

加强反腐倡廉制度建设,既是提高我们党执政能力的迫切要求,也是完善惩治和预防腐败体系的核心内容,更是从源头上预防腐败的治本之策和必由之路。制度建设在惩防体系中处于核心保障地位,是建立健全和有效发挥惩防体系作用的关键因素。改革开放以来,各地各部门积极探索反腐倡廉制度建设的新路,形成了一大批制度规定,但仍然存在一些不足。反腐倡廉制度建设需要上升到国家战略层面,要在全党进一步形成动手抓制度建设的生动局面。同时,制度建设还需要进一步增强层次性、针对性、创新性和执行力。     

反腐倡廉建设科学化:内涵、意义及实现途径

反腐倡廉建设科学化就是基于对腐败和反腐败现象和问题的科学研究,积累和创新反腐倡廉的知识,进而应用反腐倡廉的科学知识指导具体实践活动,以提高反腐倡廉效率和效力的过程。推进反腐倡廉建设科学化有助于提高党的建设科学化水平,对于反腐败斗争有着重大的现实意义,将有助于提高反腐败斗争的成效,开创党风廉政建设和反腐败斗争的新局面,支撑反腐倡廉战略功能的发挥,促进反腐倡廉建设继往开来、推陈出新、赢得国际支持。当前,推进反腐倡廉建设科学化在制度、教育、监督和惩治等方面存在着若干需要解决的问题,我们可以依托科学调查和研究、系统改进、经验提炼和学习借鉴等途径深入全面地推进反腐倡廉建设科学化。     

推进反腐倡廉建设科学化若干问题的思考

党的十七届四中全会明确提出“提高党的建设科学化水平”,十七届中纪委四次全会又提出了“提高反腐倡廉科学化水平”等重大命题。科学理解和准确把握反腐倡廉建设科学化的基本内涵和重要意义,认真总结中国特色反腐倡廉建设科学化的基本经验,深入分析我国反腐倡廉建设科学化进程中的主要问题,积极探索推进反腐倡廉科学化的具体路径,无疑具有重要的理论和实践意义。     

A Novel Solvent-based Method to Separate Duct Tape from Porous Surface for Fingerprint Development

In this study, we have proposed a novel solvent-based method using a specific concentration of 3M™ Novec™ HFE-72DE and 7200 solvents to untangle duct tape from porous article with minimal impact to the quality of latent fingerprint deposited on the sticky-side surface of duct tape. A series of experiments determined that a mixture of 30% HFE-72DE:7200 (v/v) was found to be the most effective to separate various brands of duct tape from different types of porous surface, including office copy paper, newspaper, cardboard, and tissue wipe, which had been stored for up to 30 days before untangling. Further studies also revealed that 30% HFE-72DE:7200 was compatible with three common fingerprint development methods for porous articles, namely ninhydrin, indanedione-zinc, and physical developer. The nonflammability and low toxicity nature of this novel solvent mixture also make it ideal for separating duct tape from porous surface in laboratory or at crime scene.     

A Powder-free DNA Extraction Workflow for Skeletal Samples

The processing of skeletal material poses several challenges for forensic laboratories. Current methods can be laborious, time-consuming, require dedicated equipment, and are vulnerable to contamination. In this study, various sample mass (1 × 50 mg, 3 × 50 mg, and 1 × 150 mg chip(s)) and incubation times (2, 4, and 16 h) were tested using the PrepFiler^® BTA™ Forensic DNA Extraction Kit to digest whole bone chips in lieu of powdering. The most effective method was then applied to bones and tooth fragments collected from contemporary human cadavers exposed to various environmental conditions using an automated platform. Over a third of the samples tested generated full DNA profiles without having to powder the bone/tooth fragment or further alter the manufacturer's protocol. However, for most samples resulting in incomplete STR profiles due to low amounts of DNA, slightly better results were achieved with powdered tissue. Overall, this work demonstrates the potential use of a faster, nonpowdering DNA extraction method for processing skeletal samples as an effective first-pass screening tool.     

论我国统一合同法中表见代理的构成要件

本文从表见代理制度的价值入手 ,分析出表见代理的构成要件的缺陷 ,认定其价值追求有失公平之合同法基本原则 ,从而主张把本人 (被代理人 )的过失亦作为其构成要件 ,以平衡本人与第三人 (相对人 )的利益。可是 ,借于统一合同法已颁布实施 ,对此缺陷只能且必须用限制性司法解释给予弥补     

大黄泄浊颗粒保留灌肠对非透析慢性肾脏病肾性骨病湿热证患者骨密度及血清骨形成蛋白-7的影响

目的观察非透析慢性肾脏病(chronic kidney diseases,CKD)肾性骨病湿热证患者腰椎骨密度(bone mineral density,BMD)和血清骨形成蛋白-7(bone morphogenetic protein-7,BMP-7)水平及大黄泄浊颗粒保留灌肠的干预作用。方法将64例非透析CKD 3~5期湿热证患者随机分为治疗组和对照组各32例(结果每组失访2例),并设正常组20例。两组均给予基础治疗,治疗组加用大黄泄浊颗粒保留灌肠,每日1次,疗程均为8周。治疗前后分别观察两组血尿素氮(blood urea nitrogen,BUN),血清肌酐(serum creatinine,SCr)、钙(calcium,Ca)、磷(phosphorus,P)、碱性磷酸酶(alkaline phosphatase,ALP)、甲状旁腺激素(parathyroid hormone,iPTH)、BMP-7水平及第2—4腰椎BMD。结果治疗组临床疗效显著优于对照组(P0.05)。治疗4周末和8周末,两组中医证候积分均较前一时点显著降低(P0.05),且治疗组积分均显著低于对照组(P0.05)。治疗组在降低BUN、SCr和血清P、iPTH、ALP方面,以及在升高血清Ca和肾小球滤过率估算值方面均显著优于对照组(P0.05)。与正常组比较,CKD病例组BMD和BMP-7均显著降低(P0.05);两组治疗后BMD和BMP-7均显著升高(P0.05),而治疗组BMD和BMP-7升高值均显著大于对照组(P0.05)。结论非透析CKD肾性骨病湿热证患者BMD和BMP-7水平均显著低于健康人群;大黄泄浊颗粒保留灌肠可防治非透析CKD肾性骨病,其机制可能与改善肾功能及升高血清BMP-7含量有关。     

响应面分析法优化马兰总黄酮提取工艺研究

目的 应用响应面分析法优化马兰总黄酮的提取工艺。方法 以单因素研究为基础,以总黄酮提取量为响应值,以4因素3水平的响应面分析法优化马兰总黄酮的提取工艺。结果 马兰总黄酮的最优提取工艺条件为：乙醇浓度为40%,液料比为〖DK(〗16.5∶1,〖DK)〗提取时间为2 h,提取次数3次,在该条件下,马兰总黄酮提取量预测值为162.538 mg,实际验证值为156.867 mg,并得出各因素对马兰总黄酮提取量的影响大小依次为乙醇浓度、液料比、提取次数、提取时间。结论 响应面分析法可用于优化马兰总黄酮的提取工艺,实验验证值与模型预测值基本相符。     

The new research agenda studying electoral integrity

A rapidly-growing research agenda shared by scholars and applied policy analysts is beginning to explore three questions: when do elections meet standards of electoral integrity? When do they fail to do so? And what can be done to mitigate these problems?