血栓调节蛋白表达与大鼠脑挫伤时间的相关性

目的观察大鼠实验性脑挫伤后不同时问内脑组织、血浆中血栓调节蛋白（TM）的变化,探讨其与损伤经过时间的关系。方法参照Feeney’S法建立大鼠脑挫伤模型,在伤后1h、4h、8h、12h、24h、3d、7d7个时问点提取心帆及脑组织检材,运用酶联免疫法（ELISA法）检测f血浆TM含量,用免疫组织化学方法检测脑组织中TM刖性表达。检测数据应川SPSS13．0统计软件分析处理。结果与对照组比较,TM的阳性表达、IOD值和血浆含量存挫伤后4h开始增加,至24h达到高峰,随后逐渐减少,伤后3dTM血浆含量仍高于对照组,7d后基本恢复至对照纰水平。伤后4h～3d之间各组与对照组比较均有统计学意义（P〈0．05）。结论脑挫伤后TM表达随时间变化的规律性有助于推断呐损伤时间。     

DNA甲基化及其与个体年龄相关性研究

近年来表观遗传学研究发现,基因组DNA甲基化总体水平随年龄增加而降低,同时部分位点的甲基化水平却随年龄增加而升高。本文重点介绍了DNA甲基化与年龄的相关性及其在年龄推断方面的研究进展,旨在为法医学个体年龄推断的研究提供一种新的思路。     

中国汉族6～18周岁女性人群牙齿生长发育的年龄研究

目的研究牙齿钙化程度与年龄的关系,建立利用牙齿推断中国汉族女性人群年龄的方程。方法通过对6923名6～18周岁汉族女性儿童及青少年全口曲面断层影像下颌恒牙的钙化程度进行评分;将分级值及其对应的年龄输入SPSS软件进行分析,最终建立推断年龄的方程模型;从研究样本外随机抽取已知年龄的样本181例进行肓测。结果牙齿钙化评分值与年龄相关分析结果相关系数r均大于0．6,同名牙评分值侧别间统计分析结果P〉0．05且相关系数r均大于0．93,方程拟合优度检验R^2=0．789,估计值标准误为1．28岁,盲测结果与真实年龄的平均误差为0．421±0．272岁。结论本研究所建立的方法在推断中国汉族女性6～18周岁群体年龄方面有良好的应用前景。     

Cone‐beam Computed Tomography for Analyzing Variations in Inferior Alveolar Canal Location in Adults in Relation to Age and Sex*

Abstract: Previous studies have indicated that the relative position of the inferior alveolar canal and its mental and mandibular foramina in adults vary with age and show sexual dimorphism. Conceivably, these purported differences could be of forensic value for determining identity of human remains. This study was designed to determine the influence of age and sex on the relative position of inferior alveolar canal and its foramina in cone‐beam computed tomography (CBCT) studies of adults. Existing CBCT studies of the maxillofacial region from dentate adult patients selected at random and ranging in age from 18 to 80 years (110 women and 55 men) were acquired, and the location of the inferior alveolar canal was assessed at three points: the mandibular foramen in axial view, the inferior alveolar canal in coronal view, and the mental foramen in coronal view. Measurements were also expressed for the mental foramen as the percentile position from the nearest superior bony crest to the inferior border; corresponding position of the mandibular foramen from the anterior to the posterior border of the mandibular ramus; and for the inferior alveolar canal at the level of first permanent molar from the nearest buccal bony surface to the lingual surface and from the superior alveolar crest to the inferior border. Regression analyses were performed on the variables with regard to the effects of age and sex. Most analyses resulted in no statistical significance (p < 0.05). A few of the sex‐specific traits demonstrated near‐statistically significant effects; however, these characterizations generally resulted in a 1% or less change per age decade. Overall, the results demonstrated that the relative location of the inferior alveolar canal and associated foramina in adults remain fairly constant without regard to age and sex.     

法治缘何迈向方法论时代——基于法律方法论学术报告的考察（2002——2010）

通过对法律方法论学术报告的知识梳理与分析可以发现,法治实践面临着理论准备不足、缺乏细腻理论支撑的难题。法律方法论可以为法治实践所需要的细腻法治理论提供最低限度的质疑,进而提供理论验证,并且法律方法论本身作为一种细致、精良的思维技艺能够为未来的细腻法治提供智识支撑。同时,法律方法论应该站在面向法治、维护法治的立场上,努力建构自主性的法律方法论理论体系。     

从养儿防老与政府规划看农村的养老问题

伴随着老龄化的加速、经济体制的不断变革以及人们观念的日益革新,传统的养儿防老模式开始改变,新型农村养老保险制度在政府的规划下崭露头角。将在学者们研究与论述的基础上,从中国的现状以及社会的发展等方面分析原因及应对措施。     

言息化时代区域舆论引导策略

现在我国已经进入信息化时代,信息化时代区域舆论有着明显的特点,那就是传播链广泛、传播速度快、容易被人误导等等,这些问题的存在使当前党的舆论引导工作难度不断增大。要想解决信息化时代区域舆论引导问题,必须在分析现区域舆论发展特点的基础上,详细分析舆论传播链,从控制好舆论传播链入手,辅以其他措施实现对区域舆论的有效控制,防止区域舆论异变给区域社会经济发展带来的不利影响。     

网络时代加强民主党派宣传思想工作的思考

民主党派宣传思想工作肩负着“内强素质,外塑形象”的重要职责,是民主党派自身建设的重要环节和基础性工程。面对网络时代迅猛发展给民主党派宣传思想工作带来的发展机遇和严峻挑战,要高度强化网络时代做好宣传思想工作的观念和意识,牢牢掌握宣传思想工作的主动权,充分利用网络资源加强民主党派宣传思想工作,增强宣传思想工作的针对性和实效性。     

Fracture patterns on the infant porcine skull following severe blunt impact

The objective of this study was to document patterns of fracture on infant porcine skulls aged 2-28 days (n = 57) because of a single, high energy blunt impact to the parietal bone with rigid (nondeformable) and compliant (deformable) interfaces. Fracture patterns were mapped using Geographic Information System software. For the same generated impact force, the rigid interface produced more fractures than the compliant interface for all ages. This study also showed that this increased level of impact energy versus an earlier study using a lower energy resulted in new sites of fracture initiation and also caused previously defined fractures that propagate into an adjacent bone. Several unique characteristics of bone and diastatic fracture were documented as a function of specimen age, impact energy, and interface. These data describe some baseline characteristics of skull fracture using an animal model that may help guide future studies from forensic case files.     

Are Trends in Specialization Across Arrests Explained by Changes in Specialization Occurring with Age?

The current work uses a sample of serious offenders (N = 2,086) to test the extent to which variation in specialization with age accounts for trends in specialization across arrests. Analyses show that controls for age do not have a large influence on trends across arrest in drug offense specialization or trends across arrest in miscellaneous offense specialization. In contrast, results show that controls for age do influence trends in specialization across arrests for violent offenses and for property offenses. For both of these offense types, trends in specialization across arrests prior to controls for age were positive, while trends in specialization across arrests after controls for age were negative. Results show that many of the trends in specialization across arrests found in the earlier literature are likely influenced by changes in specialization occurring with age.