Evaluation and classification of fentanyl-related compounds using EC-SERS and machine learning

Multiple analytical techniques for the screening of fentanyl-related compounds exist. High discriminatory methods such as GC–MS and LC–MS are expensive, time-consuming, and less amenable to onsite analysis. Raman spectroscopy provides a rapid, inexpensive alternative. Raman variants such as electrochemical surface-enhanced Raman scattering (EC-SERS) can provide signal enhancements with 10¹⁰ magnitudes, allowing for the detection of low-concentration analytes, otherwise undetected using conventional Raman. Library search algorithms embedded in instruments utilizing SERS may suffer from accuracy when multicomponent mixtures involving fentanyl derivatives are analyzed. The complexing of machine learning techniques to Raman spectra demonstrates an improvement in the discrimination of drugs even when present in multicomponent mixtures of various ratios. Additionally, these algorithms are capable of identifying spectral features difficult to detect by manual comparisons. Therefore, the goal of this study was to evaluate fentanyl-related compounds and other drugs of abuse using EC-SERS and to process the acquired data using machine learning—convolutional neural networks (CNN). The CNN was created using Keras v 2.4.0 with Tensorflow v 2.9.1 backend. In-house binary mixtures and authentic adjudicated case samples were used to evaluate the created machine-learning models. The overall accuracy of the model was 98.4 ± 0.1% after 10-fold cross-validation. The correct identification for the in-house binary mixtures was 92%, while the authentic case samples were 85%. The high accuracies achieved in this study demonstrate the advantage of using machine learning to process spectral data when screening seized drug materials comprised of multiple components.     

Embutramide,a Component of Tanax®(T‐61) as a New Drug of Abuse?

Tanax^®(T‐61) is a euthanasia solution commonly used in veterinary medicine in Europe. It consists of three active components: embutramide, mebezonium iodide, and tetracaine hydrochloride. Human consumption of Tanax^®(T‐61) is usually associated with suicide attempts. In our 15‐year‐long practice, embutramide was detected only three times but within a short period. First, it was found in the urine of a 42‐year‐old veterinarian, and the other two observations were made in a 16‐year‐old young man. Urine samples were analyzed using Shimadzu Prominence TOX.I.S.II. HPLC–DAD system with online SPE extraction system. Both of the two patients denied any intention to die. These cases show that this veterinary drug may also be considered as potential drugs of abuse.     

FINANCING THE WAR ON DRUGS: THE IMPACT OF LAW ENFORCEMENT GRANTS ON RACIAL DISPARITIES IN DRUG ARRESTS

This study estimates the impact of the discretionary Edward Byrne Memorial State and Local Law Enforcement Assistance Program (EBMGP) on drug arrests and crime. The 1986 and 1988 Anti‐Drug Abuse Act allocated federal funds to state and local municipalities to combat illicit drug use and violent crime associated with drug sales and trafficking. The results show that the implementation of the EBMGP resulted in an increase in police hiring, an increase in drug sales arrest rates for Blacks and Whites, and a decrease in total crime. Nonetheless, Black‐White racial disparity in the drug sales arrest rate still significantly increases by approximately 1 for every 1,000 Black residents. Our findings highlight the role of federal crime control policies in state and local policing. Although, the EBMGP was a color‐blind policy initiative, it was not race neutral in its implementation.     

The Effects of Substance Use on Offender Crime Scene Behavior

Abstract:  Substance use has an effect on an individual's propensity to commit acquisitive crime with recent studies showing substance users more likely to leave forensic material at a crime scene. An examination of acquisitive crime solved in Northamptonshire, U.K., during 2006 enabled 70 crime scene behavior characteristics to be analyzed for substance and nonsubstance use offenders. Logistical regression analyses have identified statistically significant crime scene behavior predictors that were found to be either present at or absent from the crime scene when the offender was a substance user. Most significant predictors present were indicative of a lack of preparation by the offender, irrational behavior, and a desire to steal high value, easily disposed of, property. Most significant predictors absent from the crime scene were indicative of more planning, preparation, and execution by the offender. Consideration is given to how this crime scene behavior might be used by police investigators to identify offenders.     

Detection of Acute Diazepam Exposure in Bone and Marrow: Influence of Tissue Type and the Dose‐Death Interval on Sensitivity of Detection by ELISA with Liquid Chromatography Tandem Mass Spectrometry Confirmation*

Abstract: Enzyme‐linked immunosorbent assay (ELISA) and liquid chromatography tandem mass spectrometry (LC/MS/MS) were used to detect diazepam exposure in skeletal tissues of rats (n = 15) given diazepam acutely (20 mg/kg, i.p.), and killed at various times postdose. Marrow, epiphyseal, and diaphyseal bone were isolated from extracted femora. Bone was cleaned, ground, and incubated in methanol. Marrow underwent ultrasonic homogenization. Extracts and homogenates were diluted in phosphate buffer, and then underwent solid‐phase extraction and ELISA. Relative sensitivity of detection was examined in terms of relative decrease in absorbance (ELISA) and binary classification sensitivity (ELISA and LC/MS/MS). Overall, the data showed differences in relative sensitivity of detection of diazepam exposure in different tissue types (marrow > epiphyseal bone > diaphyseal bone), which is suggestive of heterogenous distribution in these tissues, and a decreasing sensitivity with increasing dose‐death interval. Thus, the tissue type sampled and dose‐death interval may contribute to the probability of detection of diazepam exposure in skeletal tissues.     

当前我国毒品犯罪状况和特点与治理对策

当前,我国毒品犯罪形势日趋严重,跨省、跨国大案要案增多,贩毒种类多样,贩毒手段不断翻新。毒品犯罪呈内外勾结态势向我国“多头入境,全面渗透”。解决毒品问题之本在于综合治理。应将禁毒工作作为一项重要国策,长期作战;加强禁毒宣传,提高全民禁毒意识;严查重打毒品犯罪活动;落实禁吸强戒、创建“无毒社区”与开发戒毒药物工作相结合;严格执行国际禁毒公约,大力开展国际禁毒合作。     

Drugs of choice,drugs of change: Egyptian consumption habits since the 1920s

Abstract

Much has been written and published about the 25 January 2011 Egyptian revolution from the perspective of contemporary history and political science. Much less attention has focused on social policy. I am unaware of any scholarly material that has dealt with illicit drugs during the critical 2011–2016 period, yet increasing drugs consumption provided a social backdrop to the events of that period. This paper identifies historical trends in illicit drugs consumption over the course of the last century to the beginning of the Arab Spring. During much of this period hashish was the drug of choice. This paper argues that drug consumption was on the rise in Egypt well before the downfall of President Husni Mubarak in February 2011, but that it has grown markedly since the ousting of the former president. It will ask which have been and are the drugs of choice in contemporary Egypt. It will further ask how this composition has changed and why, giving special focus to the relatively new mass, opioid drug, Tramadol.     

Spirit and being: interdisciplinary reflections on drugs across history and politics

Abstract

Few commodities are as global as drugs. Cannabis, opium, heroin, amphetamines, lysergic acid diethylamide (LSD), khat, psychedelic cacti and mushrooms as well as an interminable list of other natural or synthesised substances travel and are consumed around the globe for all possible reasons. Human migration, trade, cultural trends, medical practice, political repression: together they constitute the drug phenomenon today – and indeed in much of human history. In this, drugs are spirit-like commodities, their value resting upon a fundamental ambiguity made up of individual, psychological, social, cultural, economic and medical circumstances. Defining a drug is an attempt at defining a spirit on the edge, which metamorphoses in time and space. At the same time, drugs remain a fundamentally political object. They are substances controlled by states, through mechanisms of policing, legitimated by judicial and medical evaluation, condemned often on moral grounds. Situated between a fluid social existence and a static legal dimension, drugs can become inspiring hermeneutic objects of study.     

Maintaining disorder: the micropolitics of drugs policy in Iran

Abstract

This article analyses the ways in which the state ‘treats’ addiction among precarious drug (ab)users in Iran. While most Muslim-majority as well as some Western states have been reluctant to adopt harm reduction measures, the Islamic Republic of Iran has done so on a nationwide scale and through a sophisticated system of welfare intervention. Additionally, it has introduced devices of management of ‘addiction’ (the ‘camps’) that defy statist modes of punishment and private violence. What legal and ethical framework has this new situation engendered? And what does this new situation tell us about the governmentality of the state? Through a combination of historical analysis and ethnographic fieldwork, the article analyses the paradigm of government of the Iranian state with regard to disorder as embodied by the lives of poor drug (ab)users.     

当前缉毒工作存在的主要问题及对策研究

重新审视二十年缉毒工作的思路,发现“重毒轻人”和“重案轻人”的倾向十分严重,只有淡化缴毒数．坚持打击毒品犯罪的人员基础,坚持除恶务尽,斩草除根,方能有效遏制毒品犯罪活动。结合缉毒工作实践,抽强研究和改进禁毒立法,收集、运用情报,打击新型毒品犯罪工作,是掌握禁毒工作主动权、推动禁毒斗争健康发展十分紧迫和现实的任务。