浅议易制毒化学品的法律规制

近年来,化学合成类毒品的出现对传统的毒品构成冲击,其原料的非原生性和生产的便捷性使之异军突起。中国作为易制度化学品的生产大国,面临的形势更为严峻。目前我国规制易制毒化学品的法律法规存在诸多不足,应加强对易制毒化学品行政处罚的法律位阶,不断完善管制的易制毒化学品的种类。     

AFGHAN REFUGEES: THE IMPACT ON PAKISTAN

One of the most important arenas that have been profoundly affected by the security situation in Afghanistan is Pakistan's internal security environment. The instability in Afghanistan has had a negative spill-over effect on Pakistan's domestic security scenario, as the Afghan quagmire poses immense implications on Pakistan's domestic framework. One of the important consequences of the Afghan conflict since the 1970s has been the massive inflow of the Afghan refugee population to the neighbouring Pakistan which in following years has brought about a number of demographic and security challenges to the Pakistani society. Therefore along with a number of factors, at this present juncture, Afghan refugees have also become a principal factor in determining Pakistan's Afghanistan policy.     

Evaluation of Four Fingerprint Development Methods for Touch Chemistry Using Matrix‐Assisted Laser Desorption Ionization/Time‐of‐Flight Mass Spectrometry,

Four preparation techniques for MALDI/TOF mass spectrometry were compared to determine the ability to gather intelligence for investigations through the chemical analysis of latent fingerprints, defined as “touch chemistry.” Compatible fingerprint development processes used for identification along with new techniques are necessary to evaluate touch chemistry. Ten volunteers deposited fingerprints from solvent residues containing drugs and explosives onto microscope slides. The developers included (A) fingerprint powder, (B) MALDI matrix, (C) fingerprint powder and lifting, and (D) cyanoacrylate fuming with fingerprint powder. Qualitative identification was based on ion images and spectra. The highest average detection rates (88%) were found using methods A and B. Methods C (52%) or D (18%) had limited success. Results demonstrate the importance of imaging coupled to extracted mass spectral data in detecting analytes in deposited fingerprints. Overall, the results suggest continued development of touch chemistry applications could prove useful for gathering intelligence and forensically relevant information.     

The relationship between the detection of acquisitive crime by forensic science and drug-dependent offenders

Drug- and nondrug-related acquisitive crime offences such as burglary, theft, and motor vehicle theft, were compared to assess whether drug abusers were more likely to be apprehended via forensic science techniques. Data were all acquisitive offences committed over a 6-year period within a police force area in England. Drug-dependent offenders committed a wider range of offence types than nondependent offenders, and they were significantly more likely to be detected via their DNA or fingerprints (p < 0.01). A logistic regression (n > 14,000) revealed a number of predictors that influence the detection of the crime by forensic techniques. The results indicate that a number of these predictors are of statistical significance; the most significant of these being drug use by the offender with sex, ethnicity, and employment status also being relevant. Age of the offender and number of offences committed were found not to be significant. Of the four hypotheses considered to explain this, the most likely was thought to be the physical and mental impact of drug use on crime scene behavior. Consideration is given to the disciplines of forensic science and forensic psychology working closely together to distinguish factors that influence crime scene behavior.     

The detection of sedatives in hair and nail samples using tandem LC-MS-MS

Drug screening methods were developed to detect alprazolam, clobazam, clonazepam, diazepam, midazolam, oxazepam, temazepam, triazolam, zopiclone, and selected metabolites in human hair and nail samples employing liquid-liquid extraction and tandem liquid chromatography-mass spectrometry (LC-MS-MS). Hair and nail samples were obtained from patients who had recently discontinued or were currently prescribed one or more of the targeted drugs. Prazepam was used as the internal standard for all compounds. Some components in the hair matrix gave the same transitions as some of the analytes but did not compromise the analyses because their retention times differed from those for the target compounds. The analytical run time was 8-10min. Results of the hair analysis of a DFSA victim are also presented.     

试论制贩新型毒品犯罪的特点、原因及对策

受国际毒潮的渗透和影响,我国新型毒品违法犯罪来势凶猛、发展迅速,社会危害日显突出新型毒品制贩犯罪活动呈现出国际化、现代化等特征。造成新型毒品日益严重的原因主要是制造新型毒品的原材料易购、制造工艺简单、新型毒品的科技含量日益加强,而娱乐场所为新型毒品犯罪提供了理想的温床。对此,应广泛深入的发动群众,拓展宣传教育的深度和广度;依法严厉打击毒品犯罪;加快科技强警的步伐,为构建和谐社会创造良好的社会环境。     

Increased risk of fatal intoxication and polypharmacy among psychiatric patients at death

Patients suffering from psychiatric disorders have an excess mortality and a shorter life span expectancy compared to the general population. Furthermore, they are treated with multiple drugs and are known to have an increased risk of drug abuse. In this study, we aimed at investigating the pharmaceutical drug and drug of abuse profiles of the deceased included in the Danish prospective autopsy‐based forensic study on psychiatric patients, SURVIVE. Using the postmortem systematic toxicological analysis results, we identified 129 different consumed compounds in our population (n = 443). Polypharmacy (≥5 compounds) was detected in 39.5% of the deceased. Deceased with a psychiatric diagnosis or who died from a fatal intoxication had significantly more compounds at the time of their death compared to having either no psychiatric diagnosis or another cause of death, respectively. Evidence of drug abuse was present, as 29.8% of our total population had consumed either methadone or illicit drugs of abuse, excluding tetrahydrocannabinol. Of those deceased with a psychiatric diagnosis, 33.6% had either consumed methadone or illicit drugs of abuse, a greater number than those without a psychiatric diagnosis. Fatal intoxication was the most frequent cause of death (40.6%) with methadone as the major intoxicant. Here, we found that those without a psychiatric diagnosis had fewer fatal pharmaceutical drug intoxications compared to the psychiatric diagnosis groups. Our findings add further context to understanding the excess mortality of psychiatric patents, since there is an increased occurrence of fatal intoxication, polypharmacy, and drug abuse in this population.     

The Variability of Ecstasy Tablets Composition in Brazil

The content of ecstasy tablets has been changing over the years, and nowadays 3,4‐methylenedioxymethamphetamine (MDMA) is not always present in the tablets. The aim of this study was to investigate the chemical composition in the seized tablets labeled as ecstasy. We analyzed samples from 150 different seizures made by Sao Paulo's State Police by gas chromatography–mass spectrometry. MDMA was present in 44.7% of the analyzed samples, and another twenty different active substances were identified in these tablets, such as caffeine, 2C‐B, piperazines, amphetamines, phencyclidine, and others. Methamphetamine was present in 22% of these samples. The results demonstrate a huge shift in the pattern of trafficking of synthetic drugs, where MDMA has been replaced in tablets mostly by illicit psychoactive substances, in a clear attempt to bypass the law. The great variability in the tablets composition may lead to an increased risk of drug poisoning.     

Analytical Challenge in Postmortem Toxicology Applied to a Human Body Found into a Lake after Three Years Immersion

The body of a 30‐year‐old woman was found in Como lake at a depth of about 120 meters in her own car after 3 years of immersion. The aim of this study was to evaluate psychoactive drugs as well as alcohol biomarkers in biological matrices. The following analyses were initially performed: GC‐MS systematic toxicological analysis on biological fluids and tissues; GC‐MS analysis of drugs of abuse on pubic hair; direct ethanol metabolite determination in pubic hair by LC‐MS/MS. After 7 years, the samples, that had been stored at ?20°C, were re‐analyzed and submitted to an LC‐MS/MS targeted screening method, using multiple reaction monitoring mode. These analyses detected citalopram (150–3000 ng/mL), desmethylcitalopram (50–2300 ng/mL), clotiapine (20–65 ng/mL), and ethyl glucuronide (97 pg/mg). The methods showed an acceptable reproducibility, and the concentrations of citalopram and desmethylcitalopram calculated through the two analytical techniques did not significantly differ in biological fluids.     

Medicating the salaryman lifestyle: fear-based marketing of liver stimulant drugs in postwar Japan

This article studies the heretofore unexplored fear-based print marketing campaigns for postwar hangover remedies and liver drugs sold by Japan's leading drug manufacturers of the 1950s, including Chūgai, Takeda, Tanabe, Sankyō, and Yamanouchi. It reveals that these drugs were creatively and predatorily marketed to salarymen and their wives in hundreds of newspaper and magazine ads that raised the spectre of liver damage and related diseases due to overconsumption of alcohol and tobacco. It demonstrates that the makers claimed not only that their formulations could remedy liver damage, but could even serve as prophylactics that would guard against the dangers of alcohol and nicotine poisoning and enable users to drink and smoke to excess without fear. The robust copy and clever imagery appearing in the ads also illustrate the social pressures facing salarymen to drink with colleagues after work on an almost nightly basis, as well as at a series of seasonal office parties and gatherings throughout the year. This article is the first to examine how drug makers took aim at some of postwar Japan's leading causes of ill health, alcohol and tobacco abuse, as well as chemical poisonings and even morning sickness, by selling an array of ineffectual drugs based on untested and dubious claims. It charts the drug makers' increasingly outlandish ads, the slow realization that their drugs were potentially hazardous, and their swift withdrawal from the market by 1960. It argues that, amidst a rise in alcohol overconsumption and comparatively lax testing and marketing regulations, Japan's postwar pharmaceutical firms exaggerated and preyed upon consumer health concerns in hundreds of frightening and pseudoscientific ads for largely untested and potentially hazardous drugs.