成年小鼠氯胺酮慢性中毒后脑细胞凋亡

目的研究不同持续时间和剂量下氯胺酮慢性中毒对成年小鼠脑细胞凋亡发生的影响。方法氯胺酮按不同剂量(4、10、20、30mg/kg)每周2次于成年小鼠尾静脉注射,建立小鼠氯胺酮滥用慢性中毒模型,氯胺酮连续注射1、2、4、8、12周后处死。采用透射电镜进行细胞凋亡的定性检测,以Caspase-3免疫荧光染色法和脱氧核糖核苷酸末端转移酶介导的缺口末端标记法(terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling,TUNEL)定量检测凋亡细胞数,推断凋亡发生的时间,并统计分析实验结果。结果氯胺酮染毒1周后,在透射电镜下见到脑组织海马及纹状体区域有明显的神经元凋亡,并持续至8周后;染毒1周可见Caspase-3高表达,4周后呈持续低水平表达;染毒1周后可见TUNEL阳性细胞较对照组明显增加,4周时仍处于高水平表达。结论氯胺酮尾静脉注射可致成年小鼠神经元凋亡。     

Editor’s note

ABSTRACT

Over the past decade, a small movement endorsing the use of animal abuse registries (AARs) has emerged in the United States. Today, one state, 16 counties, and the City of New York have adopted AAR legislation, and 28 other states have attempted to pass such legislation. Here, we discuss similarities between AARs and sexual offender registries in theoretical terms, discuss the nature of AAR legislation, and provide data on the use of AARs, and count the number of offenders listed in those registries at two points in time. We also provide a count of animal abuse, and potential ways that animal abuse might be counted that are not addressed in current AAR legislation. We discuss whether AARs are ‘a good idea,’ especially as a policy response that might be associated with green criminology.     

The endorsement of cognitive distortions: comparing child pornography offenders and contact sex offenders

This study examined the endorsement of cognitive distortions in child pornography offenders (CPOs), using an established assessment tool, the Abel and Becker Cognition Scale. The scale was expanded to include cognitions specific to child pornography offending, extracted from Howitt and Sheldon's Children and Sexual Activities Inventory (C&SA). Three samples of CPOs, child sex offenders and offenders with both offence types responded to the cognition items. An exploratory Principal Component Analysis suggested six main components of the scale. CPOs were significantly less likely to endorse these statements in general, and this was more pronounced on items that project blame onto the child or other people, describe a need for power and consider children as sexually active. The statements extracted from C&SA did not differentiate between the groups. These findings are discussed under consideration of the relationship between cognitive distortions and contact sex offending, and in reference to the general criticism concerning the definition and appropriate measurement of cognitive distortions.     

The quality of written expert testimony in alleged child sexual abuse: An empirical study

Abstract

The purpose of this study was to empirically evaluate written expert testimonies in cases of suspected child sexual abuse in Sweden. A total of 121 expert testimonies were rated with an instrument developed for the study, the SQX-12 (Gumpert et al., 2001) which is a 12-item checklist aimed to reflect consensus-established concepts of quality. Reports from different professional groups were compared, as were reports produced before and after the 1991 publication of national guidelines. The results suggested that the reports produced by professionals using statement analysis generally were of higher quality than reports written by professionals from child- and adolescent psychiatry. There was a slight increase in report quality, as measured by the SQX total score, over the studied years. However, it is concluded that the overall quality of written expert testimony on child credibility still does not reach the recommended level in Sweden.     

Fantasy depictions of child sexual abuse: The problem of ageplay in Second Life

Abstract

This paper explores the arguments put forward for prohibiting the possession of fantasy images of child sexual abuse within the Coroners and Justice Act 2009, and applies them to sexual ageplay in Second Life. Sexual ageplay is the virtual act of simulating child sexual abuse using animated child characters operated by consenting adult users. The arguments underpinning the legislation centre on the issue of harm and the relationship between online, virtual behaviour and real world contact offences. It is argued that extant research does not support a causal connection, although some work on fantasy offence planning and online paedophilia chat groups suggests a link. Due to the lack of empirical work in the area it is concluded that legislation to criminalise such behaviour on grounds of harm causation is currently unjustified, although prohibition of sexual ageplay for known sex offenders is recommended. Further research into the extent, use and effects of sexual ageplay is required.     

Prediction of attitudes towards child sexual abuse among three different Norwegian samples

Abstract

The aim of the current study was to reveal attitudes towards child sexual abuse and investigate predictors of such attitudes. A random sample of the Norwegian adult population (n = 296), active Christians (n = 125) and prisoners convicted of child sexual abuse (n = 36) were included in the study. The results show that women were more negative towards child sexual abuse than men, and the prisoners had more accepting attitudes than the other samples. Predictors of attitudes differed across the samples. Empathy and normlessness were the best predictors of attitudes among the random sample of adults and the active Christians. The largest predictor of attitudes among the prisoners was their view of women. The implications of the results for prevention strategies are discussed.     

A psychometric comparison of internet and non-internet sex offenders from a community treatment sample

Abstract

This paper compares psychometric test assessments of 39 men convicted of internet sex offences with 39 convicted of contact offences against a specific victim. Higher rates of socially desirable responding were identified in the internet group, as well as higher rates of emotional loneliness and under assertiveness, although the latter two findings were not statistically significant. This group also achieved lower scores measuring external locus of control, which might reflect their generally higher levels of education and employment (identified from research carried out in tandem with this work). The internet group achieved lower scores on sexualized attitudes towards children, emotional congruence with children and empathy distortions with regard to victims of child abuse. Hence, although they exhibited the kinds of general personality problems exhibited by other sex offenders, they did not support attitudes that explicitly endorse or condone the sexual abuse of children. This paper presents some hypotheses about these results and identifies further research necessary to develop understanding about this new kind of sexually abusive behaviour.     

Internet-initiated incitement and conspiracy to commit child sexual abuse (CSA): The typology,extent and nature of known cases

Abstract

This paper presents the first research on cases where offenders initiate contact with other individuals over the internet and incite, or conspire (IIIC) with, them to commit child sexual abuse (CSA). Interviews and record searches were carried out among local police services in the UK. IIIC cases were found to be diverse in terms of their typology but rare with regard to the extent of known cases. They were similar to other CSA in relation to victim and offender characteristics but were distinct with regard to offenders’ modi operandi. IIIC cases should be viewed as an additional and serious category of internet-related CSA, and one about which there needs to be much more awareness and research.     

Demographic and abuse characteristics in adolescent male sexual offenders with “special needs”

Adolescent sexual offenders with “special needs” are thought to pose different challenges for therapists working clinically. However, this population has received little attention in the literature, with the research in this area very limited. This study looked at the demographic and abuse characteristics of 24 adolescent sexual offenders with “special needs” who were compared with a group of 155 male adolescent sexual offenders with no special needs. Significant differences were found between the two groups. Those with special needs had higher levels of all forms of abuse, and differences were also found on some sub-scales of the Child Behaviour Checklist. Implications for research and clinical practice are discussed.